CAS: 64187-48-0; (2S,4R)-1-Benzyl 2-Methyl 4-Hydroxypyrrolidine-1,2-Dicarboxylate

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CAS号67-56-1 甲醇 | CAS号13504-85-3 CBZ-L-羟脯氨酸 | CAS号40216-83-9 L-羟脯氨酸甲酯盐酸盐 | CAS号501-53-1 氯甲酸苄酯 | CAS号13139-17-8 苯甲氧羰酰琥珀酰亚胺 | CAS号1499-56-5 (2S,4R)-4-羟基吡咯烷... | CAS号186581-53-3 重氮甲烷 | CAS号74-88-4 碘甲烷 | CAS号51-35-4 L-羟脯氨酸 | CAS号62210-73-5 Carbonic acid,1... | CAS号473806-21-2 (2S,4R)-4-(叔丁氧基... | CAS号95687-41-5 Cbz-反式-4-羟基-L-脯氨醇 | CAS号72180-14-4 (2S,4S)-4-氟-1,2... | CAS号618-27-9 顺式-4-羟基-L-脯氨酸 | CAS号13504-86-4 (2S,4S)-N-Cbz-4... | CAS号168263-82-9 (2S,4S)-4-((叔丁氧... | CAS号279-33-4 2-氧杂-5-氮杂双环[2.2.1]庚烷 | CAS号16217-15-5 N-Cbz-4-氧代-L-脯氨酸甲酯 | CAS号117811-78-6 (2S,4R)-Cbz-4-甲... | CAS号755707-37-0 (4s)-4-(2-萘氧基)-...

📜L-羟基脯氨酸置于氯化亚砜,碳酸氢钠体系中,用 水 作为反应溶剂,化学反应生成 N-Cbz-羟脯氨酸甲酯
参考文献:Two Prolines With A Difference: Contrasting Stereoelectronic Effects Of 4R/s-Aminoproline On Triplex Stability In Collagen Peptides [pro(X)-Pro(Y)-Gly]Nelectronic Supplementary Information (Esi) Available: 1H NMR Spectra And Coupling Constant Analysis Of 3 And 4; Synthetic Schemes For 3,4,5 And 6; Fabms Of 3 And 4; Maldi-Tof Ms Of 5 And 6; HPLC Of Peptides 5 And 6. See Http://www.Rsc.Org/suppdata/cc/b3/b308581C/
标题:Two Prolines With A Difference: Contrasting Stereoelectronic Effects Of 4R/s-Aminoproline On Triplex Stability In Collagen Peptides [pro(X)-Pro(Y)-Gly]Nelectronic Supplementary Information (Esi) Available: 1H NMR Spectra And Coupling Constant Analysis Of 3 And 4; Synthetic Schemes For 3,4,5 And 6; Fabms Of 3 And 4; Maldi-Tof Ms Of 5 And 6; HPLC Of Peptides 5 And 6. See Http://www.Rsc.Org/suppdata/cc/b3/b308581C/
摘要:在胶原肽[pro(X)-Pro(Y)-Gly]N中,当4R/s-氨基脯氨酸位于x位置时,对三重螺旋稳定性表现出ph和立体化学依赖性效应.
DOI:10.1039/b308581C

专利信息

专利号:US-9469609-B2
优先权日:2006-12-21
标 题:Synthesis of pyrrolidine compounds
发明人：ALIMARDANOV ASAF R; KRISHNAN LALITHA; ZHOU MAOTANG; WANG TING-ZHONG; REN JIANXIN; CONSIDINE JOHN LEO; WU CHARLES C; BRAZZILLO JASON; RAVEENDRANATH PANOLIL; SUTHERLAND KAREN; MIRMEHRABI MAHMOUD; DESHMUKH SUBODH S
权利人:ZEALAND PHARMA AS
摘要:Provided are methods for the preparation of certain substituted pyrrolidine compounds, forms of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride, and methods for preparing and using these forms.

专利号:US-8378099-B2
优先权日:1994-10-28
标 题:Boronic ester and acid compounds, synthesis and uses
发明人：ADAMS JULIAN; MA YU-TING; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS
权利人:MILLENNIUM PHARMACUETICALS INC; ADAMS JULIAN; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS
摘要:Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.

专利号:US-2008188545-A1
优先权日:2006-12-21
标题 :Synthesis of pyrrolidine compounds

专利号:US-2013053344-A1
优先权日:2006-12-21
标 题:Synthesis of pyrrolidine compounds

专利号:US-2015322007-A1
优先权日:2006-12-21
标题 :Synthesis of pyrrolidine compounds

专利号:DK-2468724-T3
优先权日:2006-12-21
标 题:Synthesis of pyrrolidine compounds