CAS: 617-89-0; Furan-2-Ylmethanamine

上下游产品

CAS号1121-47-7 2-呋喃甲醛肟 | CAS号98-00-0 糠醇 | CAS号98-01-1 糠醛 | CAS号617-90-3 2-氰基呋喃 | CAS号69332-23-6 methyl furan-2-... | CAS号4437-18-7 2-溴甲基呋喃 | CAS号494-47-3 三呋喃甲醛二亚胺 | CAS号1450-58-4 anti-2-furancar... | CAS号123-91-1 1,4-二氧六环 | CAS号4753-68-8 2-furanylmethan... | CAS号109403-64-7 N-(2-Furanylmet... | CAS号3139-27-3 呋喃-2-甲基对甲苯胺 | CAS号40914-13-4 2-氯-N-呋喃甲基乙酰胺 | CAS号59749-85-8 2-氰基-N-(2-呋喃基甲基)乙酰胺 | CAS号3878-19-1 麦穗灵 | CAS号5626-92-6 4-氨基-N-呋喃-2-甲基苯磺酰胺 | CAS号56541-07-2 1-(2-糠基)-2-硫脲 | CAS号4753-75-7 N-甲基糠基胺 | CAS号4650-60-6 异硫氢酸糠酯

2-(Furan-2-Ylmethyl)Isoindoline-1,3-Dione置于一水合肼体系中,用 1,4-二氧六环 作为反应溶剂,以78%的收率获得产物2-呋喃甲胺
参考文献:利用甲苯磺酰hydr作为烷基化剂合成加百利胺的空前方法†
标题:利用甲苯磺酰hydr作为烷基化剂合成加百利胺的空前方法†
摘要:公开了一种新的单罐形式的gabriel邻苯二甲酰亚胺胺合成方法,该方法利用羰基化合物通过其甲苯磺酰sur替代物作为烷基化剂.烷基化涉及将铜催化的卡宾插入邻苯二甲酰亚胺的n-h键中.基本上,该协议还为羰基化合物的脱氧加氢胺化提供了强大的工具.
DOI:10.1039/c4Ra05929H

专利信息

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:US-7279572-B2
优先权日:2003-05-22
标题:Process for the 2-stage synthesis of hexanitrohexaazaisowurtzitane starting from a primary amine
发明人：CAGNON GUY; ECK GENEVIEVE; HERVE GREGOIRE; JACOB GUY
权利人:SNPE MATERIAUX ENERGETIQUES
摘要:A subject-matter of the present invention is a novel process for the synthesis of hexanitrohexaazaisowurtzitane (HNIW), a compound of use as energetic filler in powders, propellants and explosives. n This process comprises a first stage of reaction of an α,β-dicarbonyl derivative with a primary amine which makes it possible to form a hexasubstituted hexaazaisowurtzitane derivative. n The HNIW is subsequently obtained directly, in a single reaction stage, by nitration of the hexasubstituted hexaazaisowurtzitane derivative. n This process, in only 2 stages starting from a primary amine, is particularly simple and inexpensive.

专利号:US-10266565-B2
优先权日:2011-04-12
标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

专利号:US-9809522-B2
优先权日:2015-09-11
标 题 :Selective liquefaction of lignin and biomass in a mixture of sub- and supercritical fluids in absence or presence of heterogeneous catalysts
发明人：SMIRNOVA ALEVTINA; LYNDE CHRIS; Numan-Al-Mobin Abu Md; RAJAPPAGOWDA RUDRESH BOMMADIHALLI
权利人:SOUTH DAKOTA BOARD OF REGENTS
摘要:Disclosed herein are methods for selective synthesis of specific phenolic products by means biomass or biomass products liquefaction, manipulation of the said selectivity in favor of one specific phenolic compound or a mixture of specific phenolic compounds, and the synthesis of the phenolic compounds from a liquid or biomass organic fraction produced in presence of a homogeneous catalyst in supercritical state or a mixture of said homogeneous and one or several heterogeneous catalysts mixed with water in sub-critical, near-critical, or supercritical condition.

专利号:WO-2022127640-A1
优先权日:2020-12-16
标题:Process for synthesis of furan-based diamines
发明人：GUO RUIJING; PIRES RAUL; BEUCK SASKIA; LATORRE MARTINEZ IRENE CRISTINA; PAN XIANGCHENG; JIANG YUAN
权利人:COVESTRO DEUTSCHLAND AG; GUO RUIJING
摘要:The invention provides a process for the synthesis of furan-based diamines based on renewable resources.

专利号:US-5292903-A
优先权日:1991-08-22
标 题:One step method for the preparation of difurfuryl diamines
发明人：CONNER ANTHONY H; HOLFINGER MICHAEL S; HILL JR CHARLES G; MCKILLIP WILLIAM J; REIMANN ROLF H
权利人:US DEPARTMENT OF AGRICULTURE A
摘要:A synthetic procedure for the synthesis of diamino difurfuryl compounds via a one-step, low-temperature reaction that does not require additional steps for the protection of the amino functionalities in the reactant or the deprotection of the amino functionalities in an intermediate product to give the final product is disclosed. The importance of acid concentration, reaction temperature, and reaction time to the one step method are disclosed.