CAS: 5785-06-8; 3-Methoxybenzhydrazide

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CAS号10259-22-0 3-甲氧基苯甲酸乙酯 | CAS号5368-81-0 3-甲氧基苯甲酸甲酯 | CAS号586-38-9 3-甲氧基苯甲酸 | CAS号1711-05-3 3-甲氧基苯甲酰氯 | CAS号591-31-1 3-甲氧基苯甲醛 | CAS号1874-41-5 2-(3-methoxyphe... | CAS号7154-74-7 N-benzoyl-3-met... | CAS号586-38-9 3-甲氧基苯甲酸 | CAS号289710-96-9 5-(3-甲氧基苯基)-4H-... | CAS号36770-18-0 2-(chloromethyl... | CAS号7732-39-0 Benzoicacid, 3-... | CAS号80403-33-4 N-[[cyano-(3-me...

📜3-甲氧基苯甲酸置于硫酸,一水合肼体系中,用 乙醇 作为反应溶剂,化学反应生成 3-甲氧基苯-1-碳酰肼
参考文献:设计和合成新的诺氟沙星-1,3,4-恶二唑杂种作为对耐甲氧西林的金黄色葡萄球菌(mrsa)的抗菌剂.
标题:设计和合成新的诺氟沙星-1,3,4-恶二唑杂种作为对耐甲氧西林的金黄色葡萄球菌(mrsa)的抗菌剂.
摘要:为了寻找新的抗菌药物来控制耐甲氧西林的金黄色葡萄球菌(mrsa),设计并合成了一类新的诺氟沙星-1,3,4-恶二唑杂种.评估了对药物敏感细菌金黄色葡萄球菌和mrsa临床耐药菌株的抗菌活性.化合物5K对金黄色葡萄球菌(mic:2μg/ Ml)和mrsa1-3(mic:0.25-1μg/ Ml)表现出优异的抗菌活性.时间杀灭动力学表明,化合物5K在杀死金黄色葡萄球菌和mrsa方面优于常用抗生素万古霉素.而且,化合物5K可以在短时间内抑制细菌并破坏其膜,并且对nrk-52E细胞显示出非常低的细胞毒性.还讨论了一些有趣的结构-活性关系(sar).这些结果表明这些诺氟沙星1,3,
DOI:10.1016/j.Ejps.2019.104966

专利信息

专利号:WO-9600148-A1
优先权日:1994-06-23
标题 :Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof

专利号:US-2006211603-A1
优先权日:2004-08-18
标 题:Ramoplanin derivatives possessing antibacterial activity
发明人：RAJU BORE G; CIABATTI ROMEO; MAFFIOLI SONIA I; SINGH UPINDER; ROMANO GABRIELLA; MICHELUCCI ELENA; TISENI PAOLO S; CANDIANI GIANPAOLO; KIM BUM; O'DOWD HARDWIN
权利人:VICURON PHARM INC
摘要:Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.