专利号:US-2003162992-A1 优先权日:2001-12-14 标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides 发明人:WATANABE KYOICHI A; DU JINFA 摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.
专利号:US-4460786-A 优先权日:1980-07-10 标题 :Process for the selective addition of a compound having an activated carbon atom onto a substituted conjugated diene 发明人:MOREL DIDIER 权利人:RHONE POULENC IND 摘要:The selective addition of a compound having an activated carbon atom onto the carbon atom in the 4-position of a buta-1,3-diene carrying a hydrocarbon substituent on the carbon atom in the 2-position is achieved by reacting the compound having the activated carbon atom with the buta-1,3-diene carrying the hydrocarbon substituent in water or in an aqueous-alcoholic mixture in the presence of a catalyst which consists of at least one water-soluble phosphine and at least one rhodium compound, the catalyst being in solution in the water or aqueous alcoholic mixture. The products obtained are useful as precursors of intermediates for the synthesis of vitamins and perfumes.
专利号:US-8957260-B2 优先权日:2011-02-07 标题 :Process for the oxidation of mesitol 发明人:WEYRAUCH JAN PHILIPP; WEIS MARTINE; TELES JOAQUIM HENRIQUE; EBEL KLAUS; DEGLMANN PETER 权利人:WEIS MARTINE; TELES JOAQUIM HENRIQUE; EBEL KLAUS; DEGLMANN PETER; WEYRAUCH VIVIEN ELLINOR; WEYRAUCH GUNHILD; BASF SE 摘要:The invention relates to a process for the oxidation of mesitol with singlet oxygen, which is released from hydrogen peroxide, this release taking place in the presence of a bismuth compound as catalyst. In the process, 2,4,6-trimethylquinol is formed in high yield and selectivity as product, which can be used in further reactions for the synthesis of vitamins and in particular of vitamin A and vitamin E.
专利号:US-4594460-A 优先权日:1984-03-22 标题:Process for selective C-alkylation of phenols 发明人:MIGNANI GERARD; MOREL DIDIER 权利人:RHONE POULENC SANTE 摘要:Substituted phenols of formula ##STR1## in which R 1 is in an ortho or para position relative to the phenol function and denotes ##STR2## R 2 denotes an acyclic radical optionally substituted by alkyl, hydroxy, alkoxycarbonyl, cyano or formyl, or a phenyl or naphthyl radical, and R denotes hydrogen or 1 to 4 substituents chosen from halogen, OH optionally in the form of ether or ester, alkyl, NO 2 , CHO optionally in the form of acetal, CH 3 CO--, C 6 H 5 CO--, NH 2 , alkylamino, dialkylamino or alkoxycarbonyl, it being understood that 2 symbols R may form with the phenyl nucleus a condensed aromatic ring, which comprises reacting a butadiene of formula ##STR3## with a phenol for formula ##STR4## in water in the presence of a rhodium-based catalyst, a water-soluble phosphine and optionally an inorganic or organic base. The products of formula (I) are intermediates for the synthesis of vitamin E, antioxidants, perfumes or insecticides.
专利号:US-4950368-A 优先权日:1989-04-10 标 题 :Method for paired electrochemical synthesis with simultaneous production of ethylene glycol 发明人:WEINBERG NORMAN L; GENDERS JOHN D; MAZUR DUANE J 权利人:ELECTROSYNTHESIS CO INC; SKA ASS 摘要:Paired electrochemical synthesis reactions in which ethylene glycol is formed at the cathode of a membrane divided cell at high concentrations and current efficiencies, up to 99 percent. Simultaneously, a compatible process is also conducted at the anode of the same electrochemical cell by reacting indirectly generated anode products with organic substrates to form secondary products, such as polybasic acids. The process is especially advantageous in that such secondary products, where appropriate can be further reacted with the ethylene glycol prepared from the catholyte of the same cell to form useful tertiary products, especially polyesters like polyethylene terephthalate. Mole ratios of ethylene glycol and polybasic acid can be controlled through selective use of regeneratable redox reactant.
专利号:US-7973109-B2 优先权日:2007-03-29 标 题 :Crosslinked type layered metal phosphonate compound, production process therefor, non-crosslinked type layered metal phosphonate compound, production process therefor, as well as stock solution 发明人:OGATA SHIN-ICHI; FUKUSHIMA YOSHIAKI; KAWASUMI MASAYA 权利人:TOYOTA CHUO KENKYUSHO KK 摘要:A process for producing a crosslinked type or non-crosslinked type layered metal phosphonate compound including a reaction step of reacting two or more members selected from organic diphosphonic acids or monophosphonic acids, or derivatives thereof having predetermined conditions and a metal source capable of forming an ion of a hexacoordinate metal atom as a central atom (M) of a metal oxide octahedron upon reaction under the presence of a sulfuric acid catalyst, a crosslinked or non-crosslinked metal phosphonate compound obtained by the process, as well as a stock solution used for the synthesis of the crosslinked or non-crosslinked type layered metal phosphonate compound described above.
[参考文献]: A A Toropov, Et Al. Qspr Modeling Of Octanol/water Partition Coefficient For Vitamins By Optimal Descriptors Calculated With Smiles. Eur J Med Chem. 2008 Apr;43(4):714-40. [参考文献]: A Kilanowicz, Et Al. Disposition And Metabolism Of 1,4-Dimethylnaphthalene In Rat. Int J Occup Med Environ Health. 2000;13(4):325-34. [参考文献]: Anne Tndervik, Et Al. Ralstonia Sp. U2 Naphthalene Dioxygenase And Comamonas Sp. Js765 Nitrobenzene Dioxygenase Show Differences In Activity Towards Methylated Naphthalenes. J Biosci Bioeng. 2012 Feb;113(2):173-8. [参考文献]: D E Hibbs, Et Al. An Aqueous Concentration Model For Riverine Spills. J Hazard Mater. 1999 Jan 1;64(1):37-53. [参考文献]: D S Malament, Et Al. Inhibition Of Dmba Carcinogenesis Of Hamster Buccal Pouch By Phenanthrene And Dimethylnaphthalene. Carcinogenesis. 1981;2(8):723-9.
合成参考文献
摘要:Toyota, S.; Iwanaga, T., Science of Synthesis, (2010) 45, 774. 摘要:Toyota, S.; Iwanaga, T., Science of Synthesis, (2010) 45, 761. 摘要:Dai, X.; Shi, F., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 1, 143. 参考文献:10.1007/s11103-010-9607-6 摘要:Campbell MA, Gleichsner A, Alsbury R, Horvath D, Suttle J. The sprout inhibitors chlorpropham and 1,4-dimethylnaphthalene elicit different transcriptional profiles and do not suppress growth through a prolongation of the dormant state. Plant Mol Biol. 2010 May;73(1-2):181–9. doi: 10.1007/s11103-010-9607-6.