CAS: 5193-03-3; 2-Chloro-6-Hydrazinopyridine

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45644-21-1 1626336-59-1 27032-63-9

上下游产品

CAS号2402-78-0 2,6-二氯吡啶 | CAS号4774-14-5 2,6-二氯吡嗪 | CAS号885267-14-1 2-(6-氯吡啶-2-基)乙酸 | CAS号27187-13-9 5-氯-[1,2,4]三唑并[... | CAS号1150164-74-1 1-(6-氯吡啶-2-基)-5... | CAS号35235-72-4 5-氯四唑并[1,5-a]吡啶 | CAS号1128268-00-7 1H-pyrazole-4-c... | CAS号66999-66-4 1,2,4-Triazolo[...

2,6-二氯吡嗪置于一水合肼体系中,化学反应 2.0H,以74%的收率获得产物2-氯-6-肼基吡啶
参考文献:Exploring The Unexplored Practical And Alternative Synthesis Of 3-(Trifluoromethyl)-Triazolopiperazine The Key Intermediate For Sitagliptin
标题:Exploring The Unexplored Practical And Alternative Synthesis Of 3-(Trifluoromethyl)-Triazolopiperazine The Key Intermediate For Sitagliptin
摘要:为了合成西格列汀的关键中间体3-(三氟甲基)-三唑并呱和3-(三氟甲基)-三唑吡啶,采用了工业上可行的转化方法进行实用合成.这种方法的另一个优点是通过消除常用的三氟乙酸酐和聚磷酸,提供了一种新型的环保合成三唑并呱和三唑吡啶的方法.
DOI:10.2174/1570178611310050008

专利信息

专利号:US-2023018429-A1
优先权日:2019-11-22
标 题 :Process for synthesis of (3-chloro-2-pyridyl)hydrazine
发明人：CHOCKALINGAM DEVARAJAN; DUDHAT VIPUL; KHARATKAR RAJU MAHADEV; MAO JIANHUA; VEKARIYA PANKAJKUMAR; BHATT DHARMESH BALVANTRAI
权利人:FMC CORP; FMC AGRO SINGAPORE PTE LTD
摘要:Described herein are novel methods of synthesizing (3-chloro-2-pyridyl)hydrazine. Compounds prepared by the methods disclosed herein are useful for preparation of certain anthranilamide compounds that are of interest as insecticides, such as, for example, the insecticides chlorantraniliprole and cyantraniliprole.

专利号:WO-2024054476-A1
优先权日:2022-09-09
标题:New processes for synthesis of (3-chloro-2-pyridyl)hydrazine
发明人：BHATT DHARMESH BALVANTRAI; CHOCKALINGAM DEVARAJAN; DUDHAT VIPUL; HOFFMAN CHRISTIAN; KHARATKAR RAJU MAHADEVRAO; MAO JIANHUA
权利人:FMC CORP; FMC AGRO SINGAPORE PTE LTD
摘要:Described herein are novel methods of synthesizing pyridylhydrazines from halogenated pyridines in the presence of a phase transfer catalyst. Compounds prepared by the methods disclosed herein are useful for preparation of certain anthranilamides, compounds that are of interest as insecticides, such as, for example, the insecticides chlorantraniliprole and cyantraniliprole.

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:US-11027027-B2
优先权日:2015-01-30
标 题:Pyridazinoindole compounds and methods for PET imaging
发明人：MANNING H CHARLES; CHEUNG YIU-YIN; BUCK JASON R; LI JUN
权利人:UNIV VANDERBILT
摘要:Embodiments of the invention include a novel synthesis of the translocator protein (TSPO) ligands, and methods of imaging a molecular events. Also disclosed are compounds for treatment of diseases, including cancer.

专利号:TW-202419442-A
优先权日:2022-09-09
标题 :New processes for synthesis of (3-chloro-2-pyridyl)hydrazine

专利号:EP-4061801-A1
优先权日:2019-11-22
标 题 :Process for the synthesis of (3-chloro-2-pyridyl)hydrazine