CAS: 49607-10-5; (R)-2-Amino-2-Cyclobutylacetic Acid

相似化合物

28024-69-3 155905-77-4 49607-08-1

📜在 盐酸,水体系中,用 甲醇 作为反应溶剂,化学反应 6.0H,以96%的收率获得产物d-环丁基甘氨酸
参考文献:未受保护的非天然定制α-氨基酸的化学动力学热力学拆分和s / R相互转化
标题:未受保护的非天然定制α-氨基酸的化学动力学热力学拆分和s / R相互转化
摘要:本文介绍了一种高级的通用方法,可通过中间形成相应的镍(II)螯合的席夫碱,纯化学动态热力学拆分和未经保护的特制α-氨基酸(α-Aas)s / R互变.该方法具有几乎完整的立体化学结果,广泛的底物通用性(35个实例)以及操作方便的条件,可大规模制备对映体纯形式的目标α-Aa.此外,新型的非可消旋的轴向手性配体可以定量回收和再利用,从而使整个过程在经济上和合成上都具有吸引力.
DOI:10.1021/acs.Joc.5B01292

专利信息

专利号:US-2016319312-A1
优先权日:2013-07-29
标 题 :Synthesis method for l-cyclic alkyl amino acid and pharmaceutical composition having thereof
发明人：HONG HAO; ZHENG CHANGSHENG; GUO LINA
权利人:ASYMCHEM LABORATORIES (TIANJIN) CO LTD; ASYMCHEM LIFE SCIENCE (TIANJIN) CO LTD; TIANJIN ASYMCHEM PHARMACEUTICAL CO LTD; ASYMCHEM LABORATORIES (FUXIN) CO LTD; JILIN ASYMCHEM LABORATORIES CO LTD
摘要:A synthesis method for L-cyclic alkyl amino acid and a pharmaceutical composition having the said amino acid are provide in the present disclosure provides. The synthesis method comprises: step A.) preparing a cyclic alkyl keto acid or a cyclic alkyl keto acid salt having Structural Formula (I) or Structural Formula (II), and step B.) mixing the cyclic alkyl keto acid or the cyclic alkyl keto acid salt with ammonium formate, a leucine dehydrogenase, a formate dehydrogenase and a coenzyme NAD + , and carrying out a reductive amination reaction to generate the L-cyclic alkyl amino acid, wherein the Structural Formula (I) is n n n n n n n n n n where n 1 ≧1, m 1 ≧0 and the M 1 is H or a monovalent cation; the Structural Formula (II) is n n n n n n n n n n where n 2 ≧0, m 2 ≧0, the M 2 is H or a monovalent cation, an amino acid sequence of the leucine dehydrogenase is SEQ ID No.1.