CAS: 480-64-8; 2,4-Dihydroxy-6-Methylbenzoic Acid

上下游产品

CAS号487-69-4 2,4-二羟基-6-甲基苯甲醛 | CAS号72-89-9 乙酰辅酶A | CAS号524-14-1 Malonyl CoA | CAS号504-15-4 3,5-二羟基甲苯 | CAS号3686-57-5 2,4-二甲氧基-6-甲基苯甲酸 | CAS号7028-40-2 tetraacetic acid | CAS号537-09-7 扁枝衣二酸 | CAS号480-56-8 紅粉苔酸 | CAS号548-89-0 三苔色酸 | CAS号2524-37-0 2,4-二羟基-6-甲基苯甲酸乙酯 | CAS号480-56-8 紅粉苔酸 | CAS号504-15-4 3,5-二羟基甲苯 | CAS号124-38-9 二氧化碳 | CAS号6110-37-8 2,4-二甲氧基-6-甲基苯甲酸甲酯 | CAS号2524-37-0 2,4-二羟基-6-甲基苯甲酸乙酯 | CAS号3163-24-4 RESORCINOL44MET... | CAS号3187-58-4 2,4-二羟基-6-甲基苯甲酸甲酯 | CAS号12772-57-5 根赤壳菌素 | CAS号82003-90-5 (2S)-2-[(3E)-4,...

3-Bromoorsellinic Acid置于palladium On Activated Charcoal 氢气,三乙胺体系中,用 甲醇 作为反应溶剂,以87%的收率获得产物2,4-二羟基-6-甲基苯甲酸
参考文献:苯并[α]蒽醌抗生素pd 116198的生物合成
标题:苯并[α]蒽醌抗生素pd 116198的生物合成
摘要:通过掺入乙酸钠[[1-13 C]-和[s-13 C]的混合物而获得的标记图案已证实,安古环素抗生素pd 116198的苯并[α]蒽醌骨架有不规则的衍生. [1-13 C,18 ö 2]-,和[1-13 C,2-2 ħ 3]乙酸酯和的18 ö 2揭示抗生素的氢原子和氧原子的起源.通过喂食2来测试"双链"生物合成的可能性h标记的山梨酸酯;但是,没有检测到掺入.pd 116198似乎最有可能是通过对最初形成的线性四环中间体进行重排而得到的.
DOI:10.1016/s0040-4020(01)81801-9

专利信息

专利号:US-11046978-B2
优先权日:2016-03-16
标 题:Synthesis of isoprenoids and derivatives
发明人：GONZALEZ RAMON; CLOMBURG JAMES M; CHEONG SEOKJUNG
权利人:UNIV RICE WILLIAM M
摘要:This disclosure generally relates to the use of enzyme combinations or recombinant microbes comprising same to make isoprenoid precursors, isoprenoids and derivatives thereof including prenylated aromatic compounds. Novel metabolic pathways exploiting Claisen, aldol, and acyioin condensations are used instead of the natural mevalonate (MVA) pathway or 1-deoxy-d-xylulose 5-phosphate (DXP) pathways for generating isoprenoid precursors such as isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP), and geranyl pyrophosphate (GPP). These pathways have the potential for better carbon and or energy efficiency than native pathways. Both decarboxylative and non-carboxylative condensations are utilized, enabling product synthesis from a number of different starting compounds. These condensation reactions serve as a platform for the synthesis of isoprenoid precursors when utilized in combination with a variety of metabolic pathways and enzymes for carbon rearrangement and the addition/removal of functional groups. Isoprenoid alcohols are key intermediary products for the production of isoprenoid precursors in these novel synthetic metabolic pathways.

专利号:US-5936100-A
优先权日:1996-12-16
标 题:Synthesis of functionalized macrocycles by ring closing metathesis
发明人：FUERSTNER ALOIS; LANGEMANN KLAUS; KINDLER NICOLE
权利人:STUDIENGESELLSCHAFT KOHLE MBH
摘要:The invention concerns an improved process for the preparation of macrocyclic products with 12 or more ring atoms containing one or more polar functional groups on the ring and/or one or more heteroatoms within the ring by ring closing metathesis (RCM) of suitably substituted diene precursors even if the substrates are devoid of any kind of conformational preorganization. Metal carbene complexes of Ru, Mo, W, Re, Os, which are tolerant towards the respective functional group and can either be isolated or prepared in situ are used as catalysts or catalyst precursors. Preferred catalysts or catalyst precursors are ruthenium complexes of the general type XX1LL1Ru=CRR1, wherein X, X1=halogen, L, L1=trialkylphosphine, R, R1=H, Ph, CH=CPh2 denote the most preferred embodiment. The process can be applied to the synthesis of olfactory compounds, perfumary ingredients, pheromones, crown ethers, antibiotics and pharmaceuticals for human and veterinary medicine.

专利号:US-11312979-B2
优先权日:2017-02-17
标题:Method and cell line for production of phytocannabinoids and phytocannabinoid analogues in yeast
发明人：MOOKERJEE SHOHAM; CAMPBELL ALEXANDER JAMES; WILTSHIRE ZACHARY DOUGLAS; CHEN KEVIN JOHN
权利人:HYASYNTH BIOLOGICALS INC
摘要:A method and cell line for producing phytocannabinoids and phytocannabinoid analogues in yeast. The method applies, and the cell line includes, a yeast cell transformed with a polyketide synthase CDS and a cytosolic prenyltransferase CDS. The polyketide synthase enzyme catalyzes synthesis of olivetol or methyl-olivetol, and may include Cannabis sativa olivetolic acid synthase or Dictyostelium discoideum polyketide synthase (“DiPKSâ€?). The yeast cell may be modified to include a phosphopantethienyl transferase for increased activity of DiPKS. The yeast cell may be modified to mitigate mitochondrial acetaldehyde catabolism for increasing malonyl-CoA available for synthesizing olivetol or methyl-olivetol. The prenyltransferase enzyme catalyzes synthesis of cannabigerol or a cannabigerol analogue, and may include an αββα cytosolic prenyltransferase enzyme from Streptomyces sp CL190. The yeast cell may be modified to mitigate depletion of geranyl pyrophosphate for increasing available geranyl pyrophosphate fr prenylation.

专利号:WO-2019190945-A1
优先权日:2018-03-29
标 题 :Biosynthesis of olivetolic acid
发明人：GONZALEZ RAMON; TAN ZAIGAO; CLOMBURG JAMES M
权利人:UNIV RICE WILLIAM M
摘要:We present a biosynthetic approach to engineer novel microbes, such as Escherichia coli , for the production of olivetolic acid and other aromatic polyketides, as well as various downstream products that can be made therefrom. We engineered an E. coli strain that synthesizes olivetolic acid from a principle carbon source in vivo by expressing olivetolic acid synthase and olivetolic acid cyclase with the required modules of a β-oxidation reversal for hexanoyl-CoA generation. Further, we engineered an E. coli strain that synthesizes olivetolic acid which integrated additional auxiliary enzymes for increasing both hexanoyl-CoA and malonyl-CoA, enabling the synthesis of about 75 mg/L olivetolic acid and a productivity of 9.3 mg/hr olivetolic acid produced per gram dry weight of cells.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-3578705-A
优先权日:1967-07-26
标 题:Process for the preparation of homophthalic acid
发明人：WENDLER NORMAN L; SLATES HARRY L; WEBER STUART
权利人:MERCK & CO INC
摘要:3,5-DILOWERALKOXY HOMOPHTHALIC ACIDS ARE PREPARED FROM 5,7-DILOWERALKOXY-1-INDANONES VIA THE CORRESPONDING 2-OXIMO-1-INDANONES AND 1,2-INDANDIONES AND ARE EMPLOYED AS INTERMEDIATES IN THE TOTAL SYNTHESIS OF D,1-ZEARALENONES.