CAS: 4799-68-2; 3-(Benzyloxy)Propan-1-Ol

上下游产品

2-phenyl-1,3-dioxane benzyl chloride trimethyleneglycol benzyl alcohol 1-chloro-3-benzyloxypropane 1-[(3-bromopropoxy)methyl]-benzene 1-benzyloxy-3-tosyloxypropane methyl β-benzyloxypropionate

Trimethyl-[2-(3-Phenylmethoxypropoxymethoxy)Ethyl]Silane置于magnesium Bromide体系中,用 乙醚,硝基甲烷 作为反应溶剂,化学反应 5.0H,以95%的收率获得产物3-苄氧基-1-丙醇
参考文献:新型sem醚脱保护剂:使用溴化镁的非常温和且选择性的方法
标题:新型sem醚脱保护剂:使用溴化镁的非常温和且选择性的方法
摘要:通过mgbr(2)/ Et(2)o / Meno(2)脱保护方案,已为包含sem醚基的多功能底物建立了新的不稳定性和稳定性序列.
DOI:10.1021/ol0057784

专利信息

专利号:US-7368568-B2
优先权日:2001-08-03
标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for production and the use
发明人：WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:BAYER SCHERING PHARMA AG
摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroarnides for the synthesis of edothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

专利号:US-6933385-B2
优先权日:2001-08-03
标题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use
发明人：WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:SCHERING AG
摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

专利号:US-4412958-A
优先权日:1981-10-16
标 题:Stereospecific synthesis of 5-phenyl-2S-pentanol
发明人：CUE JR BERKELEY W; MOORE BERNARD S
权利人:PFIZER
摘要:5-Phenyl-2S-pentanol is synthesized stereospecifically from S ethyl lactate. The method provides easily purified 5-phenyl-2S-pentanol useful in the synthesis of central nervous system active (CNS) agents such as levonantradol.

专利号:US-7442802-B2
优先权日:2002-06-27
标 题:Cyclooxygenase-2 selective inhibitors, compositions and methods of use
发明人：BANDARAGE UPUL K; EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; KHANAPURE SUBHASH P; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one COX-2 selective inhibitor, optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.

专利号:US-6335458-B1
优先权日:1998-02-27
标题:Intermediate compounds in the synthesis of the A ring moiety of 2-substituted vitamin D derivatives
发明人：OGASAWARA KUNIO; TAKAHASHI MICHIYASU
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:The object of the present invention is to provide novel compounds corresponding to the A ring part of vitamin D derivatives having a substituent at the 2-position. According to the present invention, there are provided compounds of the general formula (1):(wherein R1, R2 and R3, which may be the same or different, represent a hydrogen atom or a protecting group and R4 represents a lower alkyl group), intermediates for synthesizing them and a process for preparing them.

专利号:US-6989401-B2
优先权日:2000-07-19
标题:Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products
发明人：MAEDA KAZUHIRO; SONDA SHUJI; TAKEMOTO TADAHIRO; GOTO TOMOKAZU; KOBAYASHI FUJIO; KAJII MASAHIKO; KOMORITA NARUYASU; HIRAYAMA FUMIHIRO
权利人:MITSUBISHI PHARMA CORP
摘要:The present invention relates to a novel sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof. More particularly, the present invention relates to a sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof, which is useful as an inhibitor of lipopolysaccharides (LPS). In addition, the present invention relates to a novel intermediate compound useful for the synthesis of this sulfonic acid derivative of hydroxamic acid.