CAS: 4373-34-6; Ajmalicine Hydrochloride

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-2025092433-A1
优先权日:2023-09-20
标 题:Polypeptides for use in the synthesis of kratom alkaloids
发明人：CASARETTO JOSE; AKTAR TARIQ A; ROTHSTEIN STEVEN; SOUBEYRAND ERIC
权利人:MITRADYNE CORP
摘要:Described herein are polypeptides encoding enzymes for the synthesis of monoterpene indole alkaloids. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1-68, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1-68, or a fragment of the polypeptide, or the variant thereof.

专利号:WO-2013087821-A1
优先权日:2011-12-15
标题:Overproduction of jasmonates in transgenic plants
发明人：CHAMPION ANTONY
权利人:INST RECH DEVELOPPEMENT IRD
摘要:La present invention relates to the use of a nucleic sequence allowing the synthesis of Gh ERF-IIa, Gh ERF-IIb or Gh ERF-IIc in a plant in order to induce, in the plant, an overproduction or accumulation of jasmonic acid and/or OPDA. The accumulation of jasmonic acid and/or OPDA confers, in particular, to the transformed plant an improved resistance to bioagressors. The nucleic sequences, transformation methods and transformed plants according to the invention may also been used for the production of pharmaceutically important secondary metabolites whose synthesis is induced by jasmonates.

专利号:US-2025304985-A1
优先权日:2022-04-08
标题 :Genetically Engineered Plants for Increased Production of Vindoline
发明人：LEE-PARSONS CAROLYN; COLE LAUREN F
权利人:UNIV NORTHEASTERN
摘要:Two novel transcription factors, CrDELLA1 and CrDELLA2, are described in Catharanthus roseus plants. The DELLA transcription factors have a regulatory role in the synthesis of vinblastine and vincristine, two important anti-cancer compounds that have proved difficult to obtain in sufficient quantities. The present technology provides genetically modified C. roseus plants having enhanced DELLA activity, which leads to activation of multiple enzymes in the biosynthetic pathway leading to vinblastine and vincristine. The genetic modifications can be used together with activation of plant defense mechanisms and responses to light in order to boost vinblastine and vincristine synthesis.

专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:US-11072613-B2
优先权日:2016-03-02
标 题:Compositions and methods for making terpenoid indole alkaloids
发明人：DE LUCA VINCENZO; QU YANG
权利人:WILLOW BIOSCIENCES INC
摘要:Methods that may be used for the manufacture of a class of chemical compounds known as terpenoid indole alkaloids, including tabersonine and catharanthine are provided. Compositions useful for the synthesis of terpenoid indole alkaloids, including tabersonine and catharanthine are also provided. The provided compounds are useful in the manufacture of chemotherapeutic agents.