CAS: 4118-36-9; 6,7-Dimethoxy-1-Phenyl-1,2,3,4-Tetrahydro-Isoquinoline

相似化合物

155315-02-9 55580-65-9 301325-93-9

上下游产品

CAS号10172-51-7 1-phenyl-3,4-di... | CAS号100-52-7 苯甲醛 | CAS号120-20-7 3,4-二甲氧基苯乙胺 | CAS号3382-18-1 6,7-二甲氧基-3,4-二氢异喹啉 | CAS号591-51-5 苯基锂 | CAS号75767-96-3 N-[2-(2-bromo-4... | CAS号618-31-5 二溴甲苯 | CAS号67616-16-4 N-[2-(3,4-二甲氧基苯... | CAS号98-88-4 苯甲酰氯 | CAS号66040-34-4 1-(6,7-二甲氧基-1-苯... | CAS号66040-35-5 2-氯-1-(6,7-二甲氧基...

📜3,4-二甲氧基苯乙胺置于三氟乙酸体系中,90.0 °C,1.38 Mpa 条件下,反应 0.16H,反应生成 6,7-二甲氧基-1-苯基-1,2,3,4-四氢异喹啉
参考文献:体内评估选择性碳酸酐酶抑制剂作为潜在的抗惊厥药
标题:体内评估选择性碳酸酐酶抑制剂作为潜在的抗惊厥药
摘要:癫痫病是一种常见的神经系统疾病,由抑制性和兴奋性神经传递之间的不平衡引起.众所周知,神经元兴奋性与γ-氨基丁酸(gaba)能量去极化有关.hco 3-可以通过膜渗透性碳酸酐酶抑制剂抑制依赖的去极化.我们以前鉴定了一些异喹啉磺酰胺作为人类碳酸酐酶ii和vii(hca Ii和hca Vii)同工型的有效和选择性抑制剂.鉴于hca Ii和hca Vii是参与gaba介导的神经元兴奋的特定同工型,我们假设它们可以代表开发新的抗惊厥药的生物学靶标.因此,对于选定的异喹啉磺酰胺,我们初步测试了它们在dba / 2小鼠中预防音源性癫痫发作的能力.腹膜内给药后对所有化合物进行评估,其中一些化合物被证明可以保护小鼠免于惊厥.在这一系列化合物中,几种衍生物显示出对目标碳酸酐酶(即hca Ii和hca Vii)具有联合体内功效和抑制作用.具体而言,最有趣的分子是1-(4-氨基苯基)-6,7-二甲氧基-3,4-
DOI:10.1002/cmdc.201500596

专利信息

专利号:US-2876223-A
优先权日:1957-02-20
标题:Synthesis of substituted 1, 3 diazacyclopentenes and 1, 3 diazacyclohexenes
发明人：BLOOM BARRY M
权利人:PFIZER & CO C

专利号:US-2013203709-A1
优先权日:2010-08-09
标 题 :Acylsulfonamides and processes for producing the same
发明人：MANETSCH ROMAN; KULKARNI SAMEER; IYAMU IREDIA D; WANG HONG-GANG; DOI KENICHIRO; GUIDA WAYNE; SANTIAGO DANIEL; DU BOULAY COURTNEY
权利人:MANETSCH ROMAN; KULKARNI SAMEER; IYAMU IREDIA D; WANG HONG-GANG; DOI KENICHIRO; GUIDA WAYNE; SANTIAGO DANIEL; DU BOULAY COURTNEY; PENN STATE RES FOUND; UNIV SOUTH FLORIDA
摘要:The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.

专利号:US-8524947-B2
优先权日:2008-02-22
标题 :Acylsulfonamides and processes for producing the same
发明人：WANG HONG-GANG; MANETSCH ROMAN; HU XIANGDONG; KULKARNI SAMEER; SUN JIAZHI
权利人:WANG HONG-GANG; MANETSCH ROMAN; HU XIANGDONG; KULKARNI SAMEER; SUN JIAZHI; UNIV SOUTH FLORIDA; H LEE MOFFITT CANCER CT & RES
摘要:The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.