CAS: 39806-90-1; 4-Iodo-1-Methyl-1H-Pyrazole

相似化合物

121669-70-3 191980-54-8 50877-42-4

上下游产品

CAS号3469-69-0 4-碘吡唑 | CAS号74-88-4 碘甲烷 | CAS号930-36-9 1-甲基吡唑 | CAS号37687-18-6 1-(1-甲基-1H-吡唑-4-基)乙酮 | CAS号3994-50-1 1-甲基-4-硝基吡唑 | CAS号10199-69-6 1-methyl-4-phen... | CAS号179055-29-9 4-(1-甲基-1H-吡唑-4... | CAS号288148-34-5 吡唑-4-磺酰氯 | CAS号5952-93-2 1-甲基-1H-吡唑-4-羧酸甲酯 | CAS号37921-11-2 1-methyl-4-(4-m...

1-甲基吡唑-4-羧酸置于potassium Phosphate,碘,三乙胺体系中,用 乙腈 用作溶剂,化学反应 21.0H,反应生成1-甲基-4-碘-吡唑
参考文献:碘作为末端氧化剂,(杂)芳族羧酸的脱羧铃木-宫浦偶合†
标题:碘作为末端氧化剂,(杂)芳族羧酸的脱羧铃木-宫浦偶合†
摘要:建立了用于脱羧铃木-宫浦型偶联的新方法.该方法使用碘或溴源作为脱羧介体和末端氧化剂,因此避免了以前需要化学计量的过渡金属盐.我们的新协议允许通过(杂)芳族羧酸与芳基硼酸的偶联来构建有价值的联芳构架.该脱羧化suzuki反应的范围已经极大地多样化,从而允许先前不可获得的非邻位取代的芳族酸进行该转化.该方法还得益于催化剂用量低和不存在化学计量过渡金属添加剂的优点.
Doi:10.1039/c9Cc01817D

专利信息

专利号:US-9982005-B2
优先权日:2013-04-04
标 题 :Macrolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

专利号:US-2024309003-A1
优先权日:2021-05-04
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN; PANDYA BHAUMIK; KAPLAN ALAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:CN-118290284-A
优先权日:2024-04-02
标 题 :Synthesis method and application of alpha-carbonyl amide compound

专利号:CN-111205226-A
优先权日:2020-01-22
标题 :Synthesis method of 1-methyl-4-iodopyrazole