专利号:WO-0100609-A1 优先权日:1999-06-29 标题:Method for synthesis of n-homocysteine thiolactonyl retinamide 发明人:KAZIMIR MICHAEL; WILSON RAY E II 权利人:UNIV BAYLOR; KAZIMIR MICHAEL; WILSON RAY E II 摘要:The present invention describes methods of synthesis for N-homocysteine thiolactonyl retinamide (thioretinamide), a compound that has anticancer and antiatherogenic properties. The present invention further describes methods for the synthesis of N-homocysteine thiolactonyl retinamido cobalamin (thioretinaco), a compound that has potential anticancer, antineoplastic, antiviral, and antiatherogenic properties.
专利号:US-2019177392-A1 优先权日:2014-09-23 标 题 :Synthesis of glp-1 peptides 发明人:PENIAS NAVON SHARON; NAVEH SHIRLY; VASILEIOU ZOI; BARLOS KONSTANTINOS 权利人:NOVETIDE LTD 摘要:Disclosed are processes for the synthesis of GLP-1 peptides, such as liraglutide and semaglutide, and a process for purifying liraglutide.
专利号:US-5880295-A 优先权日:1994-02-16 标 题 :Process for the preparation of diamine intermediates useful in the synthesis of HIV protease inhibitors 发明人:KALTENBACH III ROBERT FRANK 权利人:DU PONT PHARM CO 摘要:The present invention provides a process for the preparation of compounds of formula (V) below, and analogs thereof, which are useful as intermediates for the synthesis of HIV protease inhibitors, including cyclic ureas. ##STR1##
专利号:US-6287818-B1 优先权日:2000-04-25 标 题 :Method for synthesis of N-homocysteine thiolactonyl retinamido cobalamin and uses thereof 发明人:KAZIMIR MICHAL; WILSON II F RAY 权利人:UNIV BAYLOR 摘要:The present invention describes methods for the synthesis of N-homocysteine thiolactonyl retinamido cobalamin (thioretinaco), a compound that has potential anticancer, antineoplastic, antiviral, and antiatherogenic properties.
专利号:US-6723843-B2 优先权日:1996-08-26 标题:Oligosaccharide synthesis 发明人:TOTH ISTVAN; DEKANY GYULA; KELLAM BARRY 权利人:ALCHEMIA PTY LTD 摘要:The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention provides reagents, reagent kits and methods for solid-phase oligosaccharide synthesis.
专利号:US-7160856-B2 优先权日:1997-04-16 标 题 :α-O-linked glycoconjugates, methods of preparation and uses thereof 发明人:DANISHEFSKY SAMUEL J; SAMES DALIBOR; HINTERMANN SAMUEL; CHEN XIAO TAO; SCHWARZ JACOB B; GLUNZ PETER; RAGUPATHI GOVINDASWAMI; LIVINGSTON PHILIP O; KUDUK SCOTT; WILLIAMS LAWRENCE 权利人:SLOAN KETTERING INST CANCER 摘要:The present invention provides novel alpha-O-linked glycoconjugates such as alpha-O-linked glycopeptides, as well convergent methods for synthesis thereof. The general preparative approach is exemplified by the synthesis of the mucin motif commonly found on epithelial tumor cell surfaces. The present invention further provides compositions and methods of treating cancer using the alpha-O-linked glycoconjugates.
参考标题: Methods, Processes And Intermediates For Preparing Chroman Compounds Procédés, Processus Et Intermédiaires Pour La Préparation De Composés Chromane 摘要:This Disclosure Describes An Economical And Scalable Method And Process To Synthesize The Calcium Sensing Receptor (Casr) Modulating Agent 2-Methyl-5-((2R,4S)-2-((((R)-1-(Naphthalen-1-Yl)Ethyl)Amino)Methyl)Chroman-4-Yl)Benzoic Acid, Its Intermediates And Pharmaceutically Acceptable Salts Therefor. Uses Of Said Intermediates For Synthesis Of Compounds Which May Be Intermediates To The Synthesis Of 2-Methyl-5-((2R,4S)-2-((((R)-1-(Naphthalen-1-Yl)Ethyl)Amino)Methyl)Chroman-4-Yl)Benzoic Acid Are Also Described Herein.
合成参考文献
参考文献:10.1016/j.bmcl.2009.12.078 摘要:Sathe M, Derveni M, Allen M, Cullen DC. Use of polystyrene-supported 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline for the preparation of a hapten–protein conjugate for antibody development. Bioorganic & Medicinal Chemistry Letters. 2010 Mar;20(5):1792–5. doi: 10.1016/j.bmcl.2009.12.078.