CAS: 38222-83-2; 2,6-Di-Tert-Butyl-4-Methylpyridine

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20336-15-6 585-48-8 33538-09-9

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CAS号630-18-2 三甲基乙腈 | CAS号41792-83-0 Li2(TMM)(TMEDA)2 | CAS号3282-30-2 特戊酰氯 | CAS号75-85-4 叔戊醇 | CAS号1538-75-6 特戊酸酐 | CAS号143321-89-5 Acetamide, 2,2,... | CAS号67-56-1 甲醇 | CAS号115-10-6 二甲醚 | CAS号160142-36-9 2,6-di-tert-but... | CAS号603-33-8 三苯基铋 | CAS号598-53-8 甲基异丙基醚 | CAS号538-86-3 苄基甲基醚 | CAS号540-67-0 甲乙醚 | CAS号267875-66-1 (2,2-difluoro-2... | CAS号81142-32-7 4-(溴甲基)-2,6-二(叔丁基)吡啶

2,6-二叔丁基吡啶置于(1,5-Cyclooctadiene)(Methoxy)Iridium(I) Dimer,C21H30Clnppd,Potassium Tert-Butylate,4,4'-二叔丁基-2,2'-二吡啶体系中,用 四氢呋喃,2-甲基-2-丁醇 用作溶剂,化学反应 36.0H,反应生成2,6-二叔丁基-4-甲基吡啶
参考文献:钯催化的芳基,杂芳基和硼酸乙烯基酯的甲基化
标题:钯催化的芳基,杂芳基和硼酸乙烯基酯的甲基化
摘要:报道了一种使芳基,杂芳基和乙烯基硼酸酯直接甲基化的方法,该方法涉及碘甲烷与由钯和ptbu 2 Me催化的芳基,杂芳基和乙烯基硼酸酯的反应.这种转化发生的范围非常广,并且适合于通过硼酸酯进行生物活性化合物的后期衍生化.通过串联形成碳-硼键形成反应和钯催化的甲基化反应,证明了该方法的独特功能.
Doi:10.1021/acs.Orglett.9B00025

专利信息

专利号:US-10995049-B2
优先权日:2019-07-19
标 题 :Total synthesis of prostaglandin J natural products and their intermediates
发明人：LI JIAMING; XU CHEN; AHMED TONIA S; GRUBBS ROBERT H; STOLTZ BRIAN M
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure is directed to methods of preparing prostaglandin J natural products by stereoretentive metatheses reactions and intermediates used in the synthesis of these natural products, including the use of intermediates of Formula (I-A), where R 1 is defined in the specification

专利号:US-7939679-B2
优先权日:2006-01-19
标题:Method for synthesis of ciguatoxin CTX1B and compounds useful for the synthesis of ciguatoxin CTX1B
发明人：HIRAMA MASAHIRO; INOUE MASAYUKI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:Disclosed is a method for total synthesis of CTX1B, which is developed for the synthesis of a ciguatoxin analogue such as CTX3C and enables the more efficient application of an established reaction to the total synthesis of CTC1B. More specifically, disclosed is a method for total synthesis of CTX1B comprising; an O.S-acetal formation for synthesizing a novel compound (3); a radical cyclization reaction for constructing a 9-membered ring formation reaction including a novel compound (6) through a novel compound (8) and yielding a compound (D); and a deprotection for yielding CTX1B. Also disclosed are novel compounds (1) to (8) which are particularly useful for synthesis of CTX1B and can be used for the synthesis of a ciguatoxin analogue.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-5442065-A
优先权日:1993-09-09
标 题:Synthesis of tetrahydroquinoline enediyne core analogs of dynemicin
发明人：MAGNUS PHILIP D; ILIADIS THEODORE; EISENBEIS SHANE A; FAIRHURST ROBIN A
权利人:UNIV TEXAS
摘要:A process is described for the preparation of the core azobicyclo[7.3.1]tridecaenediyne moiety of the antitumor antibiotic dynemicin. The synthesis allows efficient production of the enediyne as a stable, compound in good yield from the adamantyl N-protected azabicyclo[7.3.1]tridecadiyne. The adamantyl protecting group is employed in the starting material, N-adamantyl dihydroquinoline or N-adamantyl 6-methoxy quinoline. Also disclosed are process for the synthesis of 3-hydroxy-6-methoxyquinoline and several N-substituted derivatives of azobicyclo[7.3.1]tridecaenediyne. Solid tumor and leukemia assays were performed on the analogs of dynemicin. The results suggest a method that these compounds will useful in treating certain types of leukemias and solid tumors. The disclosed synthesis provides a route to new dynemicin intermediates and analogs which will allow development of second and third generation dynemicins.

专利号:US-8318427-B2
优先权日:2005-12-29
标 题 :Use of acid scavengers for the synthesis of standard length and long-mer nucleic acid arrays
发明人：KUIMELIS ROBERT G; MCGALL GLENN H; GOLDBERG MARTIN J; XU GUANGYU
权利人:KUIMELIS ROBERT G; MCGALL GLENN H; GOLDBERG MARTIN J; XU GUANGYU; AFFYMETRIX INC
摘要:Protective groups which may be cleaved with an activatable deprotecting reagents are employed to achieve a highly sensitive, high resolution, combinatorial synthesis of pattern arrays of diverse polymers. In preferred embodiments of the instant invention, the activatable deprotecting reagent is a photoacid generator and the protective groups are DMT for nucleic acids and tBOC for amino acids. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.

专利号:US-4914220-A
优先权日:1988-05-23
标题 :Process for synthesis of E-2-methyl-α,β-unsaturated aldehydes
发明人：DESMOND RICHARD; MILLS SANDER G; VOLANTE RALPH P; SHINKAI ICHIRO
权利人:MERCK & CO INC
摘要:A process is described for the synthesis of E-2-methyl-α,β-unsaturated aldehydes, which are useful as intermediates in the synthesis of the macrolide structure of the immunosuppressant FK-506. These compounds are also useful as ultraviolet radiation absorbers.