CAS: 37239-51-3; Wilfordin

该化合物是主要从Wilfordia植物物种中提取的天然藻类,该化合物的特点是复杂的分子结构,包括有助于其生物活动的多种功能组.Wilfordine表现出了显著的药理特性,包括潜在的抗炎和止痛作用,使其对药化学感兴趣.其行动机制可能涉及...

英文名称Wilfordin
中文名称雷公藤碱
IUPAC名称(52R,53R,54R,55S,55aR,56R,57R,58S,59S,59aS,510S,9R)-55a-(acetoxymethyl)-57-(benzoyloxy)-59,8-dihydroxy-52,59,8,9-tetramethyl-2,7-dioxo-53,54,55,55a,56,57,58,59-octahydro-52H-3,6-dioxa-1(3,2)-pyridina-5(2,8)-3,9a-methanobenzo[b]oxepinacyclononaphane-54,55,56,510-tetrayl tetraacetate
其它别名Wilfordine; 8,11-Epoxy-9,12-Ethano-11,15-Methano-5H,- 11H-[1,9]Dioxacyclooctadecino[4,3-B]Pyridine- 5,17(18H)-Dione,10,13,22,23-Tetrakis- (Acetyloxy)-12-[(Acetyloxy)Methyl]-14- (Benzoyloxy)-7,8,9,10,12,13,14,15,19,20- Decahydro-18,21-Dihydroxy-8,18,21- Trimethyl-,(8R,9R,10R,11S,12S,13R,14R,15S,- 21S,22S,23R)-; 8α-Acetoxy-2-Benzoyloxy-2-De(Acetoxy)-8-Deoxo-26-Hydroxyevonimine; (8R,9R,10R,11S,12S,13R,14R,15S,21S,22S,23R)-10,13,22,23-Tetrakis(Acetyloxy)-12-[(Acetyloxy)Methyl]-14-(Benzoyloxy)-7,8,9,10,12,13,14,15,19,20-Decahydro-18,21-Dihydroxy-8,18,21-Trimethyl-,8,11-Epoxy-9,12-Ethano-11,15-Methano-5H,11H-[1,9]Dioxacyclooctadecino[4,3-B]Pyridine-5,17(18H)-Dione; Wilfordin; Wtlfordine; 8,11-Epoxy-9,12-Ethano-11,15-Methano-5H,11H-[1,9]Dioxacyclooctadecino[4,3-B]Pyridine-5,17(18H)-Dione,10,13,22,23-Tetrakis(Acetyloxy)-12-[(Acetyloxy)Methyl]-14-(Benzoyloxy)-7,8,9,10,12,13,14,15,19,20-Decahydro-18,21-Dihydroxy-8,18,21-Trimethyl-,(8R,9R,10R
CAS编号37239-51-3
MFCD编号:MFCD20133904
FDA UNII编号:PU2C6Y564G
分子式:C43H49NO19分子量:883.85
产品CID: 1382356
产品分类生物化工 → 提取物

相似结构搜索
产品信息参考;;;;
InChIKey: XQDBHSNYTFRCNJ-FRHHWUQZSA-N
InChI=1S/C43H49NO19/c1-20-29-27(16-13-17-44-29)37(51)56-18-39(7)28-30(57-22(3)46)34(59-24(5)48)42(19-55-21(2)45)35(60-25(6)49)31(61-36(50)26-14-11-10-12-15-26)33(62-38(52
计算化学: 氢键受体数20.0氢键供体数2.0可旋转键数14.0

物理性质

熔点175-6°C
沸点895.5±65.0 °C(预测)
闪点495.4 °C
密度1.44±0.1 g/cm3(预测)
pKa:11.63±0.70(预测)
PSA:272.98
LogP:1.2714
折射率1.597
蒸汽压1.79E-34 mmHg at 25 °C
溶解性Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
外观形态粉末

MSDS等安全信息

警示词Danger
危险描述H301-H311-H331-
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P405-P501-

上下游产品

acetic anhydride alatamine 1-Desacetylwilfordine

合成工艺路线路线简述

📜乙酸酐,Alatamine 反应生成 Wilfordine
参考文献:大叶黄杨(Euonymus Alatus Forma Striatus(Thunb.)Makino)的一种新生物碱阿拉特明和一种杀虫性生物碱小花ford碱的分离和结构.
标题:大叶黄杨(Euonymus Alatus Forma Striatus(Thunb.)Makino)的一种新生物碱阿拉特明和一种杀虫性生物碱小花ford碱的分离和结构.
摘要:一种新的生物碱alatamine 5和杀虫生物碱雷公藤6用evonine一起分离2,新evonine 3,和euonymine 4从卫矛备考叶蝉(藤)牧野(家庭卫矛科).通过化学和光谱方法完全建立了阿拉米特5和维甲酸6的结构.进行了阿拉坦胺5向野生素6的转化.
Doi:10.1016/0040-4020(78)80097-0

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献

参考文献:10.5281/zenodo.5794106
摘要:The LOTUS Initiative for Open Natural Products Research: frozen dataset union wikidata (with metadata) | DOI:10.5281/zenodo.5794106
参考文献:10.1016/s0031-9422(98)00618-9
摘要:Li W, Li B, Chen Y. Sesquiterpene alkaloids from Tripterygium hypoglaucum. Phytochemistry. 1999 Mar;50(6):1091–3. doi: 10.1016/s0031-9422(98)00618-9.