CAS: 32897-26-0; 1-[3-(Dimethylamino)Propyl]-3-Ethylurea

相似化合物

4607-26-5 52338-87-1 1792-17-2

上下游产品

CAS号25952-53-8 1-乙基-(3-二甲基氨基丙基... | CAS号109-55-7 3-二甲氨基丙胺 | CAS号109-90-0 异氰酸乙酯 | CAS号19227-13-5 4-甲基苯甲酰胺肟 | CAS号5373-87-5 N-羟基-4-甲氧基苯羧酰亚胺 | CAS号613-92-3 苄胺肟 | CAS号6066-82-6 N-羟基琥珀酰亚胺 | CAS号1143515-85-8 6-(2,4,6-trioxo... | CAS号1892-57-5 1-(3-二甲基氨基丙基)-3...

📜1-(3-二甲基氨基丙基)-3-乙基碳二亚胺置于吡啶,2-吗啉乙磺酸,水体系中,用 Aq. Buffer 用作溶剂,化学反应生成1-乙基-3(3-二甲基氨基)脲
参考文献:燃料驱动的动态组合库
标题:燃料驱动的动态组合库
摘要:在动态组合库中,分子在热力学控制下可逆地相互反应以形成复杂的网络.在生物系统中,化学反应网络通过化学能的转换在动力学控制下运行.因此,我们通过化学反应循环将能量转导的概念引入了动态组合库.在文库中,单体可以低聚,低聚物可以去低聚,低聚物可以重组.有趣的是,我们发现文库组件的动力学受转酰基作用支配,这是一种平衡反应.相比之下,图书馆的动力学是由燃料驱动的激活决定的,这是一种非平衡反应.最后,我们发现自组装可以通过反馈机制在影响反应动力学方面发挥重要作用.同时运行的反应和反馈机制的相互作用会导致滞后效应,其中燃料竞争的结果取决于过去发生的事件.在未来的工作中,我们设想通过使用催化活性基序和包含信息的单体修改构建块来使库多样化.
Doi:10.1021/jacs.1C01616

专利信息

专利号:US-6469065-B1
优先权日:1996-02-02
标 题:Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use
发明人：GARVEY DAVID S; SCHROEDER JOSEPH D; DE TEJADA INIGO SAENEZ; GASTON RICKY D; SHELEKHIN TATIANA E; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated α-adrenergic receptor antagonists, and novel compositions containing at least one nitrosated and/or nitrosylated α-adrenergic receptor antagonist, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are a substrate for nitric oxide synthase, and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one α-adrenergic receptor antagonist, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing benign prostatic hyperplasia, hypertension, congestive heart failure, variant (Printzmetal) angina, glaucoma, neurodegenerative disorders, vasospastic diseases, cognitive disorders, urge incontinence, or overactive bladder, and for reversing the state of anesthesia.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-8304409-B2
优先权日:2002-07-03
标 题:Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
发明人：EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI
权利人:EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI; NICOX SA
摘要:The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.

专利号:US-2014220082-A1
优先权日:2011-06-28
标 题:Adhesive complex coacervates and methods of making and using thereof
发明人：STEWART RUSSELL J
权利人:STEWART RUSSELL J; UNIV UTAH RES FOUND
摘要:Described herein is the synthesis of adhesive complex coacervates and their use thereof. The adhesive complex coacervates are produced by reacting (a) at least one poly anion comprising a plurality of activated ester groups, and (b) at least one polycation comprising a plurality of nucleophilic groups, wherein the nucleophilic groups react with the activated ester groups to produce a new oovalent bond between the polycation and the polyanion. The adhesive complex coacervates described herein have low interfacial tension with water and wettable substrates. When applied to a wet substrate they spread over the interface rather than beading up. The adhesive complex coacervates have numerous biological applications as bioadhesives and drug delivery devices. In particular, the adhesive complex coacervates described herein are particularly useful in wet or underwater applications and situations where water is present such as, for example, physiological conditions.

专利号:US-11981777-B2
优先权日:2018-08-20
标 题:Synthesis of hyperbranched polymethacrylates and polyacrylates by a haloinimer approach
发明人：PUGH COLEEN; LIU CHENWEI; GONZALEZ CESAR LOPEZ; ZHAO CHENYING
权利人:PUGH COLEEN; LIU CHENWEI; GONZALEZ CESAR LOPEZ; ZHAO CHENYING; UNIV AKRON
摘要:A new synthetic pathway for hyperbranched polyacrylates and polymethacrylates including the steps of preparing an inimer and polymerizing the inimer to form hyperbranched polymers or copolymers.

专利号:US-9346850-B2
优先权日:2006-03-01
标题:Method of producing peptide
发明人：MURAO HIROSHI; MORIO KEN-ICHIRO; MITSUDA MASARU
权利人:KANEKA CORP
摘要:The present invention is related to a method of producing a peptide, characterized in contacting a reaction mixture with a base after a condensation reaction to hydrolyze while a basic condition is maintained until a ratio of a remaining unreacted active ester of an acid component is decreased to 1% or less in a liquid phase peptide synthesis method. According to the invention, a target peptide of high purity can be simply and efficiently produced by a continuous liquid phase synthesis method. Further, the present invention is related to a method of producing a peptide, characterized in using an amide-type solvent immiscible with water in a liquid phase peptide synthesis method. According to the invention, various peptides can be produced by the liquid phase synthesis method without being restricted by the amino acid sequence of the target peptide.