CAS: 25140-86-7; 2-(2-Chlorophenoxy)Propanoic Acid

上下游产品

2-(2-chlorophenoxy)propanoic acid methyl ester Ethyl 2-(2-chlorophenoxy)propionate 2-(2-Chloro-phenoxy)-propionic acid isopropyl ester (R)-methyl 2-(2-chlorophenoxy) propionate di(1-naphthyl)methyl (S)-2-(2-chlorophenoxy)propanoate

2-(2-氯苯氧基)丙酸置于氯化亚砜,水,三乙胺体系中,用 甲基叔丁基醚,苯 用作溶剂,化学反应 14.0H,反应生成2-(2-氯苯氧基)丙酸
参考文献:(r,S)-2-氯苯氧基吡唑啉化物作为新型底物,可改善脂肪酶催化的水解分辨率
标题:(r,S)-2-氯苯氧基吡唑啉化物作为新型底物,可改善脂肪酶催化的水解分辨率
摘要:首先选择在温度为45oc的条件下以南极假丝酵母脂肪酶b作为生物催化剂,以3-(2-吡啶基)吡唑为吡咯和水饱和的甲基叔丁基醚作为反应介质的最佳反应条件进行([r,小号)-2-(4-Chlorophenoxyl)azolides(1,2,3,4).与(r,S)-2-苯基丙酰基3-(2-吡啶基)吡唑内酯或(r,S)-α-甲氧基苯基乙酰基3-(2-吡啶基)吡唑内酯,在相同的反应条件下,具有优异的对映选择性,每种对映体的活性均高出两个数量级以上.然后分辨率扩展到其他([r,小号)-3-(2-吡啶基)吡唑酰胺(5,6,7含有2-氯,3-氯或2,4-二氯取代基,提供非常好的)(é > 48)达到出色的(e > 100)对映选择性.热力学分析1,2,和4,5,6,7证明了酰基或离去基团对不同的焓和熵对吉布斯自由能差异的深远影响.彻底的动力学分析进一步表明,在6的基础上,4和7的出色对映体比率分别是由于
Doi:10.1002/chir.21024

专利信息

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:US-5491167-A
优先权日:1993-01-29
标题 :Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses
发明人：ISHIHARA SADAO; KOGEN HIROSHI; KOGA TEIICHIRO; KITAZAWA EIICHI; SERIZAWA NOBUFUSA
权利人:SANKYO CO
摘要:Compounds of formula (I): ##STR1## and their salts and esters have the ability to inhibit the synthesis of cholesterol, and can thus be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.