CAS: 24696-26-2; C16-Ceramide

相似化合物

124753-97-5 54164-50-0 121459-09-4

上下游产品

D-erythro-3-O-Benzoyl-N-palmitoyl-sphingosin (2S,3R,4E)-2-amino-4-°Ctadecene-1,3-diol 4-nitrophenyl palmitate (2S,3R,4E)-1,3-benzylidene-2-(hexadecanoylamido)-4-°Ctadecene-1,3-diol1-OTBDPS ceramide (2S,3R,4E)-1-(triphenylmethyl)-2-(hexadecanamido)-4-°Ctadecene-1,3-diol (2S,3R,4E)-3-benzoyl-2-(hexadecanamido)-4-°Ctadecene-1,3-diol Benzoic acid (E)-(R)-1-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-hexadecanoylamino-ethyl]-hexadec-2-enyl ester

📜正十四烷基三苯基溴化膦置于吡啶,4-二甲氨基吡啶,Sodium Tetrahydroborate,Sodium Periodate,正丁基锂,Sodium Azide,4-甲基苯磺酸吡啶,溶剂黄146,二苯二硫醚体系中,用 四氢呋喃,1,4-二氧六环,吡啶,甲醇,正己烷,二氯甲烷,环己烷,水,N,N-二甲基甲酰胺,异丙醇 用作溶剂,化学反应 265.25H,反应生成N-棕榈酰神经鞘氨醇
参考文献:从d-葡萄糖高度立体选择性地合成2(S),3(R),4E-和2(S),3(R),4Z-N-十四烷酰基鞘氨醇
标题:从d-葡萄糖高度立体选择性地合成2(S),3(R),4E-和2(S),3(R),4Z-N-十四烷酰基鞘氨醇
摘要:摘要从1,2:5,6-Di-O-异亚丙基-α-开始,分十步完成了4-E-和4-Z-D-赤型神经酰胺的合成,总产率约为20-30%. D-葡萄糖呋喃糖.使用e-和z-5-脱氧-1,2-O-异亚丙基-5-C-十四叉基-α-D-木呋喃糖作为关键中间体.
Doi:10.1016/0008-6215(86)84010-1

专利信息

专利号:US-9643915-B2
优先权日:2013-03-15
标题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-9708354-B2
优先权日:2013-03-15
标 题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-9546161-B2
优先权日:2001-07-16
标题:Synthesis of UDP-glucose: N-acylsphingosine glucosyl transferase inhibitors
发明人：HIRTH BRADFORD H; SIEGEL CRAIG
权利人:GENZYME CORP
摘要:Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.

专利号:US-2024336559-A1
优先权日:2021-10-06
标 题 :Anti-fungals compounds targeting the synthesis of fungal sphingolipids
发明人：OJIMA IWAO; HARANAHALLI KRUPANANDAN; DEL POETA MAURIZIO; GARG ASHNA
权利人:UNIV NEW YORK STATE RES FOUND
摘要:The present invention provides a compound having the structure: n n n n n n n n n n n n wherein n R 3 , R 4 , R 5 , R 6 , and R 7 are each independently, H, halogen, CN, —CF 3 , —OCF 3 , —NO 2 , alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycle, —OH, —OAc, —OR 13 , —COR 13 , —CH 2 OR 13 , —SH, —SR 13 , —SO 2 R 13 , —NH 2 , —NHR 13 , —NR 14 R 15 , —NHCOR 12 , or —CONR 14 R 15 ; n R 9 , R 10 , R 11 , and R 12 are each independently, H, CN, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, —OAc, —COR 13 , —SH, —SR 13 , —SO 2 R 13 , —NH 2 , —NHR 13 , —NR 14 R 15 , —NHCOR 12 , or —CONR 14 R 15 ;n wherein each occurrence of R 13 is independently alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R 14 is independently —H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R 15 is independently —H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, n n wherein when R 14 is methyl, R 15 is not methyl; n wherein at least one of R 9 , R 10 , R 11 , and R 12 is not H; n wherein at least one of R 3 , R 4 , R 5 , R 6 , and R 7 is not H.

专利号:EP-1239813-B1
优先权日:1999-12-23
标题:Extract of blue-green alga spirulina and the use thereof in cosmetic skin-care and body care agents
发明人：SCHLOTMANN KORDULA; WALDMANN-LAUE MARIANNE; JASSOY CLAUDIA; KAETEN MELANIE; KOEHLER EVA-MARIA; PULZ OTTO; KURTH ELKE
权利人:HENKEL KGAA
摘要:The invention relates to an aqueous or aqueous-alcoholic extract of the blue-green algal taxon Spirulina, characterized in that it contains at least 10 wt. % magnesium in relation to the dry weight of said extract. The inventive blue-green alga extract is an efficacious component for stimulating intracellular synthesis of ATP and matrix proteins and differentiation of keratinozytes. The blue-green alga extract is used in topical preparations for cleaning and cosmetic care of the skin and hair, in addition to the production of agents for dermatological treatment of the skin.

专利号:US-12325678-B2
优先权日:2017-06-16
标 题 :Anti-fungals compounds targeting the synthesis of fungal sphingolipids
发明人：OJIMA IWAO; DEL POETA MAURIZIO; LAZZARINI CRISTINA; HARANAHALLI KRUPANANDAN; SUN YI
权利人:UNIV NEW YORK STATE RES FOUND
摘要:The present invention provides a compound having the structure: n nand use of the compound for inhibiting the growth of or killing.