CAS: 17665-02-0; (R)-2-((S)-2-Amino-4-Methylpentanamido)-4-Methylpentanoic Acid Dihydrate

化学文摘社编号为17665-02-02, 允许在化学数据库中精确识别;与许多微粒剂一样,其稳定性,溶解性和再活性可能受到诸如pH和温度等因素的影响,这些因素是实验应用中的重要考虑因素;

结构式图片

相似化合物

3303-31-9 73401-65-7 88743-98-0

物理性质

MSDS等安全信息

上下游产品

CAS号23032-21-5 H-D-Leu-OMe.HCl | CAS号71730-80-8 Cbz-Leu-D-Leu-OMe | CAS号76863-45-1 (S)-benzyl (1-a... | CAS号2883-36-5 dl-leu-dl-leu | CAS号328-38-1 D-亮氨酸 | CAS号61-90-5 L-亮氨酸

合成工艺路线路线简述

  • 合成目标产物 H-Leu-D-Leu-Oh 主要起始原料 D-Leucine Methyl Ester Hydrochloride
  • (文献来源)合成步骤主要原料 D-Leucine Methyl Ester Hydrochloride
📜Cbz-Leu-D-Leu-Ome置于sodium Hydroxide,Palladium On Activated Charcoal,乙醇体系中,化学反应生成L-亮氨酰-D-亮氨酸二水合物
参考文献:Smith Et Al.,Journal Of Biological Chemistry,1952,Vol. 199,P. 801,808
标题:Smith Et Al.,Journal Of Biological Chemistry,1952,Vol. 199,P. 801,808

海关参考信息

专利信息


专利号:US-3814732-A
优先权日:1971-10-21
标 题:Modified solid supports for solid phase synthesis
发明人：WANG S
权利人:HOFFMANN LA ROCHE
摘要:SOLID SUPPORT MATERIALS USED IN THE SOLID PHASE SYNTHESIS OF COMPLEX ORGANIC MOLECULES MAY BE MODIFIED BY INTRODUCTION OF A P-OXY-BENZYL ALCOHOL OR A P-OXY-BENZYLOXYCARBONYLHYDRAZIDE LINKING GROUP TO PRODUCE MODIFIED SUPPOETS USEFUL IN SOLID PHASE PREPARATION OF PROTECTED PRODUCT FREE ACIDS AND PROTECTED PRODUCT HYDRAZIDES RESPECTIVELY. THE RESULTING PROTECTED PRODUCTS ARE PARTICULARLY USEFUL IN THE FRAGMENT CONDENSATION APPROACH TO THE SYNTHESIS OF LARGE, COMPLEX ORGANIC MOLECULES.

专利号:DE-2250861-A1
优先权日:1971-10-21
标 题 :CARRIER MEASURES FOR THE SYNTHESIS OF COMPLEX, ORGANIC MOLECULES IN THE SOLID PHASE

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: Anand Sitaram, Et Al. Differential Recognition Of A Dileucine-Based Sorting Signal By Ap-1 And Ap-3 Reveals A Requirement For Both Bloc-1 And Ap-3 In Delivery Of Oca2 To Melanosomes. Mol Biol Cell. 2012 Aug;23(16):3178-92.
[参考文献]: Balraj Doray, Et Al. The Gamma/sigma1 And Alpha/sigma2 Hemicomplexes Of Clathrin Adaptors Ap-1 And Ap-2 Harbor The Dileucine Recognition Site. Mol Biol Cell. 2007 May;18(5):1887-96.
[参考文献]: De Michael Chung, Et Al. Enantioselective Molecular Recognition Between Beta-Sheets. J Am Chem Soc. 2004 Mar 17;126(10):3062-3.
[参考文献]: Griet Van Zeebroeck, Et Al. Transport And Signaling Via The Amino Acid Binding Site Of The Yeast Gap1 Amino Acid Transceptor. Nat Chem Biol. 2009 Jan;5(1):45-52.
[参考文献]: Lesley Colgan, Et Al. Dileucine Motif Is Sufficient For Internalization And Synaptic Vesicle Targeting Of Vesicular Acetylcholine Transporter. Traffic. 2007 May;8(5):512-22.

合成参考文献


参考文献:10.1007/978-3-662-25457-8_5
参考文献:10.1038/nchembio.132
摘要:Van Zeebroeck G, Bonini BM, Versele M, Thevelein JM. Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor. Nat Chem Biol. 2009 Jan;5(1):45–52. doi: 10.1038/nchembio.132.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知