CAS: 1643757-72-5; 4-(5-(2-(3,5-Bis(Trifluoromethyl)Phenyl)-N,2-Dimethylpropanamido)-4-(O-Tolyl)Pyridin-2-yl)-1-Methyl-1-((Phosphonooxy)Methyl)Piperazin-1-Ium Chloride Hydrochloride
- 英文名称4-(5-(2-(3,5-Bis(Trifluoromethyl)Phenyl)-N,2-Dimethylpropanamido)-4-(O-Tolyl)Pyridin-2-yl)-1-Methyl-1-((Phosphonooxy)Methyl)Piperazin-1-Ium Chloride Hydrochloride
- 中文名称盐酸磷奈妥匹坦*
- IUPAC名称4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium chloride hydrochloride
- 其它别名Fosnetupitant Chloride; Fosnetupitant Chloride Hydrochloride [who-Dd]; Unii-Zr36Mfa9P8; Fosnetupitant (Chloride Monohydrochloride ); Fosnetupitant Dihydrochloride; Fosnetupitant Chloride Hydrochloride Component Of Akynzeo For Injection
- CAS编号1643757-72-5
- FDA UNII编号:ZR36MFA9P8
- 分子式:C31H37Cl2F6N4O5P分子量:761.53
- 产品CID: 835230
- 同类组份化合物CAS1643757-72-5 (HCl)1703748-89-3 (inner salt)1643757-79-2 (citrate)1643757-81-6 (mesylate)1643757-83-8 (calcium)1643757-84-9 (sodium)
- 产品分类有机原料 → 有机杂环化合物 → 二嗪烷类
物理性质
MSDS等安全信息
合成工艺路线路线简述
📜福奈妥匹坦置于盐酸体系中,用 1,4-二氧六环,甲醇,二氯甲烷 用作溶剂,化学反应 3.0H,反应生成盐酸磷奈妥匹坦*
参考文献:Jp2015/17121
标题:Jp2015/17121
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
2905110000-甲醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-12071421-B2
优先权日:2011-11-29
标题:Process for the synthesis of substituted chloromethyl dialkylphosphates
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Schwartzberg L, Navari R, Clark-Snow R, Arkania E, Radyukova I, Patel K, Voisin D, Rizzi G, Wickham R, Gralla RJ, Aapro M, Roeland E. Phase IIIb Safety and Efficacy of Intravenous NEPA for Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Patients with Breast Cancer Receiving Initial and Repeat Cycles of Anthracycline and Cyclophosphamide (AC) Chemotherapy. Oncologist. 2019 Dec 4. pii: theoncologist.2019-0527. doi: 10.1634/theoncologist.2019-0527. [Epub ahead of print] doi: 10.1016/j.ejps.2019.105041. Epub 2019 Aug 9. doi: 10.1002/cncr.32429. Epub 2019 Aug 5. doi: 10.2217/fon-2018-0872. Epub 2019 Mar 12. doi: 10.1080/17460441.2019.1567487. Epub 2019 Feb 4. doi: 10.1080/17425247.2019.1553954. Epub 2018 Dec 18. doi: 10.1080/14656566.2018.1494726. Epub 2018 Jul 9. doi: 10.1093/annonc/mdy169.
合成参考文献
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2018)
📝 需求与反馈
尽可能描述清楚需求与问题信息
