CAS: 14447-15-5; Propyl 2-Cyanoacetate

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CAS号71-23-8 正丙醇 | CAS号372-09-8 氰基乙酸 | CAS号302561-09-7 2-氨基-4,5,6,7-四氢... | CAS号93966-57-5 2-氰基-3-(4-甲氧苯基)...

丙醇,氰乙酸置于硫酸体系中,用 1,4-二氧六环 用作溶剂,化学反应生成氰乙酸正丙酯
参考文献:基于两个参数塔夫特方程的1,4-二恶烷中伯醇与脂肪族单羧酸酯化反应速率的预测方法
标题:基于两个参数塔夫特方程的1,4-二恶烷中伯醇与脂肪族单羧酸酯化反应速率的预测方法
摘要:研究了脂肪族一元羧酸与伯醇在1,4-二恶烷中作为惰性溶剂的酯化反应速率.在恒定体积的间歇式反应器中,在60oc的恒定温度,固定的离子强度和ph下,将酸与1-丙醇酯化,将醇与乙酸酯化作为模型反应物.为了评价反应速率,应用了平衡反应的精确动力学方程.在这些条件下,对于低反应物,浓度反应速率仅取决于反应物的结构,因此可以通过具有两个塔夫脱系数的相关方程(感应效应和空间效应)进行预测.从这些方程式,可以估计其他酸-醇对的酯化反应速率常数.
Doi:10.1002/kin.20845

专利信息

专利号:US-4284582-A
优先权日:1978-04-28
标 题 :Process for the preparation of cyclopropane derivatives, intermediates in the synthesis of pyrethroid insecticides
发明人：KAYE ALBERT E; TUCKER ALAN C
权利人:ICI LTD
摘要:Compounds of formula: wherein both groups X are chlorine, bromine or trifluoromethyl, or one X is chlorine or bromine and the other is trifluoromethyl, and Y is -CN or -COOR in which R is an alkyl group, are obtained by (A) reacting a compound of the formula: wherein X1 is chlorine or bromine, with a compound of the formula: X2C=CH-CH=C(CH3)2 in the presence of metallic copper or at least one copper salt and a base, or (B) reacting a compound of the formula: Y-CH2-CN with a compound of the formula: X2C=CH-CH=C(CH3)2 and chlorine or bromine, in the presence of at least one reducible copper salt and a base, or (C) reacting a compound of formula: X-CH2-CN with a compound of the formula: wherein X1 is chlorine or bromine, in the presence of at least one copper salt. The compounds are intermediates in the synthesis of pyrethroid insecticides.

专利号:BR-102012016838-A2
优先权日:2012-06-29
标题 :SYNTHESIS OF CYANOACRYLATE MONOMERS FOR AVAILABILITY IN THE PRODUCTION OF TOPIC ADHESIVES

专利号:EP-0007154-B1
优先权日:1978-04-28
标题:Process for the preparation of cyclopropane derivatives, intermediates in the synthesis of pyrethroid insecticides

专利号:EP-0007154-A1
优先权日:1978-04-28
标 题 :Process for the preparation of cyclopropane derivatives, intermediates in the synthesis of pyrethroid insecticides

专利号:CN-120136757-A
优先权日:2023-12-04
标题:Synthesis method of 6-hydroxy-2-azaspiro [3.3] heptane compounds