CAS: 14389-86-7; 2-Benzyloxybenzoic Acid

相似化合物

5896-17-3 3381-87-1 63888-93-7

上下游产品

2-苯氧基苯甲酸甲酯 Methyl 2-(Benzyloxy)Benzoate 55142-16-0
2-苄氧基苯甲醛 2-(Phenylmethoxy)Benzaldehyde 5896-17-3
2-苯基甲氧基苯甲酸乙酯 Ethyl 2-(Benzyloxy)Benzoate 63888-93-7
Benzyl 2-(Benzyloxy)Benzoate 14389-87-8
2-苄氧基苯甲醇 2-Benzyloxybenzyl Alcohol 3381-87-1
水杨酸 Salicylic Acid 69-72-7
2-苯基甲氧基苯甲腈 2-(Benzyloxy)Benzonitrile 74511-44-7
水杨酸甲酯 Methyl Salicylate 119-36-8

水杨酸甲酯置于potassium Carbonate体系中,用 四氢呋喃,水,丙酮 用作溶剂,化学反应生成2-苄氧基苯甲酸
参考文献:基于维生素d3的芳香a环类似物作为刺猬通路抑制剂的结构与活性之间的关系
标题:基于维生素d3的芳香a环类似物作为刺猬通路抑制剂的结构与活性之间的关系
摘要:对一系列基于维生素d3(vd3)类似物的结构-活性关系的研究结合了功能不同的芳香族a环模拟物,提供了对脚手架特征的关键见解,这些特征可导致有效的,选择性的刺猬(hh)途径抑制.制备并评估了三个类似的亚类,这些亚类包含(1)在芳族a-环的邻位或对位单取代,(2)杂芳基或联芳基部分或(3)在芳族a-环上的多个取代基.在六元环上掺入单个或多个亲水部分的芳香族a环模拟物在依赖hh的小鼠胚胎成纤维细胞和培养的癌细胞中均抑制hh途径(ic 50值0.74-10μm).进行了初步研究以探究最活跃的类似物vd3和5抑制hh信号传导的细胞机制.这些研究表明,Vd3的抗hh活性主要归因于维生素d受体,而5则通过单独的机制影响hh抑制作用.
Doi:10.1021/jm401812D

专利信息

专利号:US-6063919-A
优先权日:1998-08-14
标题:Process for the synthesis of exochelins
发明人：GAUDIOSO LARRY A; WEGLARZ MICHAEL A
权利人:KEYSTONE BIOMEDICAL INC
摘要:A process for the synthesis of an Exochelin comprising the steps of generating L-N-[(2-benzyloxy-(benzoyl)] serine or L-N-[2-benzyloxy (benzoyl)] threonine, creating L-N-t-Boc- epsilon -hydroxynorleucine and reacting same to produce L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester, providing a dicarboxylic acid and forming an O-benzyl methyl hydroxamate from the dicarboxylic acid, coupling the O-benzyl methyl hydroxamate with the L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester to give an L-N2-Boc-N6-methyl,N6-(benzyloxy) lysine 2-trimethylsilylethyl ester which incorporates the dicarboxylic acid as modified above, removing the N-tert-butoxycarbonyl protecting group from the L-N2-Boc-N6-methyl, N6-(benzyloxy) lysine 2-trimethylsilylethyl ester to yield a substituted lysine, and coupling the same with the L-N-[2-benzyloxy (benzoyl) serine or -threonine to yield a 2-trimethyl silylethyl ester of dibenzyl Exochelic acid, transforming the 2-trimethyl silylethyl ester of dibenzyl Exochelic acid to dibenzyl Exochelic acid, preparing benzyl epi-cobactin, forming an ester bond between the dibenzyl Exochelic acid and benzyl epi-cobactin to form an intermediate, and, hydrogenolytically removing three benzyl groups from said intermediate, resulting in the synthesized Exochelin. More particularly, a synthesis for Exochelin 786SM (R) is disclosed wherein the dicarboxylic acid is suberic acid and the serine form is utilized.

专利号:US-2016207909-A1
优先权日:2015-01-20
标 题 :Synthesis Method of Anti-Cancer Drug UK-1 and Derivatives Thereof
发明人：HUANG YUNG-TZUNG
权利人:HUANG YUNG-TZUNG
摘要:A synthesis method of anti-cancer drug UK-1 includes: mixing methyl 2-amino-3-hydroxybenzoate, aldehyde and molecular sieves to form a mixture and firstly refluxing the mixture to form a first reactant; hydrolyzing the first reactant in a basic solution to form a hydrolyzed solution and secondly refluxing the hydrolyzed solution to form a second reactant; and dehydrating the second reactant and the methyl 2-amino-3-hydroxybenzoate in an acidic solution to form a dehydrated solution and thirdly refluxing the dehydrated solution to form an anti-cancer drug UK-1 or at least one derivative thereof.

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries

专利号:WO-0009547-A1
优先权日:1998-08-14
标题:Novel process for the synthesis of exochelins

专利号:US-8524740-B2
优先权日:2010-07-15
标 题 :Synthesis and anticancer activity of aryl and heteroaryl-quinolin derivatives
发明人：KUO SHENG-CHU; LEE KUO-HSIUNG; HUANG LI-JIAU; CHOU LI-CHEN; WU TIAN-SHUNG; WAY TZONG-DER; CHUNG JING-GUNG; YANG JAI-SING; HUANG CHI-HUNG; TSAI MENG-TUNG
权利人:KUO SHENG-CHU; LEE KUO-HSIUNG; HUANG LI-JIAU; CHOU LI-CHEN; WU TIAN-SHUNG; WAY TZONG-DER; CHUNG JING-GUNG; YANG JAI-SING; HUANG CHI-HUNG; TSAI MENG-TUNG; TAIRX INC
摘要:A compound of Formula I is disclosed as follows: n n n n n n n n n n n n or a pharmaceutically acceptable salt, prodrug, solvate, or metabolite thereof, wherein n R is hydrogen, P(â•?O)(OH) 2 , P(â•?O)(O(C 1 -C 18 )alkylene(C 6 -C 20 )aryl) 2 , P(â•?O)(OH)(OM), P(â•?O)(OM) 2 , Pâ•?O(O 2 M), S(â•?O)(OH) 2 , S(â•?O)(O(C 1 -C 18 )alkylene(C 6 -C 20 )aryl) 2 , S(â•?O)(OH)(OM), S(â•?O)(OM) 2 ; n M is a monovalent or divalent metal ion, or alkylammonium ion; n W is (C 6 -C 20 )aryl, (C 6 -C 20 )heteroaryl, (C 1 -C 18 )alkyl(C 6 -C 20 )aryl, (C 1 -C 18 )alkyl(C 6 -C 20 )heteroaryl, hydroxy(C 6 -C 20 )aryl, hydroxy(C 6 -C 20 )heteroaryl, (C 1 -C 18 )alkoxy(C 6 -C 20 )aryl, (C 1 -C 18 )alkoxy(C 6 -C 20 )heteroaryl, (C 1 -C 18 )alkylenedioxy(C 6 -C 20 )aryl, (C 1 -C 18 )alkylenedioxy(C 6 -C 20 )heteroaryl, halo(C 6 -C 20 )aryl, halo(C 6 -C 20 )heteroaryl, (C 1 -C 18 )alkylamino(C 6 -C 20 )aryl, (C 1 -C 18 )alkylamino(C 6 -C 20 )heteroaryl, (C 1 -C 18 )cycloalkylamino(C 6 -C 20 )aryl, or (C 1 -C 18 )cycloalkylamino(C 6 -C 20 )heteroaryl, and their OR 8 substutes; n R 5 is (C 1 -C 18 alkoxy, hydrogen, hydroxyl, O—(C 1 -C 18 )alkyl(C 6 -C 20 )aryl, halo or OR 8 , or R 5 and R 6 are (C 1 -C 18 )dioxy provided that R 7 is hydrogen; n R 6 is hydroxyl, O—(C 1 -C 18 )alkyl(C 6 -C 20 )aryl, halo or OR 8 , (C 1 -C 18 )alkoxy, (C 1 -C 18 )alkylamino, or (C 1 -C 18 )cycloalkylamino, or R 6 and R 7 are (C 1 -C 18 )dioxy provided that R 5 is hydrogen; n R 7 is hydrogen, halo or OR 8 , hydroxyl, or O—(C 1 -C 18 )alkyl(C 6 -C 20 )aryl; and n R 8 is P(â•?O)(OH) 2 , P(â•?O)(O(C 1 -C 18 )alkyl(C 6 -C 20 )aryl) 2 , Pâ•?O)(OH)(OM), or P(â•?O)(OM) 2 , Pâ•?O(O 2 M).