专利号:US-12006291-B2 优先权日:2022-01-11 标 题 :Processes for the preparation of 4,6,7-trifluoro-1H-indole-2-carboxylic acid 发明人:ZHU KAICHENG; WANG TAO; ZHANG JIAJUN; CAO HUI; SHEN RUICHAO; WANG GUOQIANG; WU GEORGE G; OR YAT SUN 权利人:ENANTA PHARM INC 摘要:The present invention relates to processes for preparing a Compound (1): n nor a pharmaceutically acceptable salt or solvate thereof. Compound (1) is useful as in many pharmaceutical agents, especially is useful as key intermediate in the synthesis of certain SARS-CoV-2 3CLpro inhibitors.
专利号:US-4051132-A 优先权日:1974-01-23 标 题 :Process for epimerizing beta-lactam antibiotic compounds by means of an acid quench 发明人:FIRESTONE RAYMOND A 权利人:MERCK & CO INC 摘要:Total synthesis methods employ 7-amino (6-amino in the case of a penicillin derivative) group in the alpha configuration. The instant invention provides a general route for preparing the 7β-amino (or 6β-amino) compound, through the formation of an imino-containing intermediate, followed by hydrolysis to the desired epimer. Novel intermediate products are provided. The compounds having the desired beta epimer can be converted to acylamino-antibiotics.
专利号:BR-112019014061-A2 优先权日:2017-01-23 标 题 :compounds of formula i, intermediates b, intermediates c, intermediates ii and intermediates d, composition, use, method to combat phytopathogenic fungi, seed and process for the synthesis of the compounds of formula i
专利号:JP-2005522511-A 优先权日:2002-04-16 标题:Process for the synthesis of monohydroperfluoroalkanes, bis (perfluoroalkyl) phosphinates and perfluoroalkylphosphonates
专利号:US-2957931-A 优先权日:1949-07-28 标 题 :Synthesis of compounds having a carbonphosphorus linkage 发明人:HAMILTON LYLE A; WILLIAMS ROBERT H 权利人:SOCONY MOBIL OIL CO INC
专利号:US-4167630-A 优先权日:1975-12-24 标 题 :Process for epimerizing beta-lactam antibiotic compounds, and related products 发明人:FIRESTONE RAYMOND A 权利人:MERCK & CO INC 摘要:Through total synthesis methods developed in the assignee's laboratories, new as well as old penicillin and cephalosporin compounds (all containing the beta-lactam functional group) have been prepared. One of the key intermediates prepared by total synthesis has the 7-amino (6-amino in the case of a penicillin derivative) group in the alpha configuration. The instant invention provides a general route for preparing the 7β-amino (or 6β-amino) compound, through the formation of an imino-containing intermediate, followed by hydrolysis to the desired epimer. Novel intermediate products are provided. The compounds having the desired beta epimer can be converted to acylaminoantibiotics.
摘要:Merck Index - O'Neil MJ, Heckelman PE, Dobbelaar PH, Roman KJ (eds). The Merck Index, An Encyclopedia of Chemicals, Drugs, and Biologicals, 15th Ed. Cambridge, UK: The Royal Society of Chemistry, 2013.