CAS: 1127442-82-3; Rel-4-((3Ar,4S,7R,7As)-1,3-Dioxo-1,3,3A,4,7,7A-Hexahydro-2H-4,7-Methanoisoindol-2-yl)-N-(Quinolin-8-yl)Benzamide

该化合物是一个小分子抑制器,主要以其在调控Wnt信号路径中的作用而闻名,它对各种生物过程至关重要,包括细胞扩散和分化;该化合物的特点是有能力有选择地抑制蛋白分解器的活动,从而防止下游Wnt目标基因的激活;IWR-1-endo经常在研究环境中用于研究Wnt信号在发育生物学和癌症中的影响;该物质通常以固体的形式呈现,并且溶于有机溶剂,适合体外试验;其行动机制及其特性使其成为调查细胞信号路径复杂性的宝贵工具;此外,由于其潜在的治疗影响,IWR-1-endo在药物开发方面,特别是在针对与异常信号相关的疾病方面,引起了兴趣;关于任何化学物质,在实验室环境中与IWR-1-endo合作时,应当观察适当的处理和安全程序.

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合成工艺路线路线简述

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    专利信息


    专利号:US-2022298019-A1
    优先权日:2019-06-06
    标题 :Direct Synthesis of Aluminosilicate Zeolitic Materials of the IWR Framework Structure Type and their Use in Catalysis
    发明人:PARVULESCU ANDREI-NICOLAE; XIAO FENG-SHOU; MENG XIANGJU; WU QINMING; MUELLER ULRICH; YOKOI TOSHIYUKI; ZHANG WEIPING; KOLB UTE; MARLER BERND; DE VOS DIRK; HONG XIN
    权利人:BASF SE
    摘要:The present invention relates to a zeolitic material having the IWR type framework structure, wherein the zeolitic material comprises YO 2 and X 2 O 3 in its framework structure, wherein Y is a tetravalent element and X is a trivalent element, and wherein the framework structure of the zeolitic material comprises less than 5 weight-% weight-% of Ge calculated as GeO 2 and based on 100 weight-% weight-% of YO 2 contained in the framework structure, and less than 5 weight-% weight-% of B calculated as B 2 O 3 and based on 100 weight-% weight-% of X 2 O 3 contained in the framework structure. Further, the present invention relates to a process for preparing a zeo-litic material having the IWR type framework structure, wherein the zeolitic material comprises YO 2 and X 2 O 3 in its framework structure, wherein Y is a tetravalent element and X is a trivalent element.

    专利号:CN-113966251-A
    优先权日:2019-06-06
    标题:Direct synthesis of aluminosilicate zeolitic materials of the IWR framework structure type and their use in catalysis

    专利号:EP-3980178-A1
    优先权日:2019-06-06
    标题 :Direct synthesis of aluminosilicate zeolitic materials of the iwr framework structure type and their use in catalysis

    专利号:WO-2022191130-A1
    优先权日:2021-03-08
    标 题:Method for proliferating cardiomyocytes, method for producing cardiomyocytes, and cardiomyocyte proliferating agent
    发明人:YAMASHITA JUN; YOSHIOKA MIKI
    权利人:UNIV KYOTO
    摘要:Provided are a method for proliferating cardiomyocytes, a method for producing cardiomyocytes, and a cardiomyocyte proliferating agent capable of contributing to cardiac regenerative medicine, that make it possible to induce proliferation of human cardiomyocytes by a drug. The method for proliferating cardiomyocytes, method for producing cardiomyocytes, and cardiomyocyte proliferating agent, including a step for culturing cardiomyocytes in the presence of one or more compounds selected from the group consisting of ALK inhibitors, cytochrome P450 omega hydroxylase inhibitors, and fatty acid synthesis inhibitors

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    主要参考文献


    1: Wang W, Lai S, Xiao Z, Yan H, Li Y, Zhang Y, Wu Y, Wang L. IWR-1 Inhibits Collagen-Induced Platelet Activation and Protects against Thrombogenesis. Hamostaseologie. 2019 Nov;39(4):392-397. doi: 10.1055/s-0038-1676822. Epub 2019 Mar 8.
    150:141-149. doi: 10.1016/j.bcp.2018.01.037. Epub 2018 Feb 8.
    3: Wang WM, Gao YM, Zheng XF, Jin HZ. IWR-1 attenuates the promotional effect of IL-36γ in a mouse model of psoriasis. BMC Immunol. 2024 Nov 23;25(1):78. doi: 10.1186/s12865-024-00669-1.
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