CAS: 11000-17-2; Vasopressin
该化合物是甲状腺内合成的,由脊髓下垂体释放的甲状腺激素.它通过对V1和V2受体采取行动,在调节水保留量,血压和血管音调方面发挥着关键作用. Vasopressin在临床环境中被广泛使用,以管理糖尿病的无西pidus,化粪休克,以及由于强效血管抑制和抗二尿性而导致的内爆.它的合成类像 desmopressin 一样, 提供了强化选择性和长期活动. 化合物的稳定, 特性和精细化的行动机制使得它成为治疗和研究应用中的宝贵工具.
- 英文名称Vasopressin
- 中文名称加压素
- IUPAC名称(S)-N-((S)-1-((2-amino-2-oxoethyl)amino)-5-guanidino-1-oxopentan-2-yl)-1-((4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)pyrrolidine-2-carboxamide
- 其它别名Adh(Hormone); Leiormone; Pitressin; Pituitrin; Tonephin; Vasophysin; 1-[19-Amino-13-Butan-2-Yl-10-(2-Carbamoylethyl)-7-(Carbamoylmethyl)-16-[(4-Hydroxyphenyl)Methyl]-6,9,12,15,18-Pentaoxo-1,2-Dithia-5,8,11,14,17-Pentazacycloicosane-4-Carbonyl]-N-[1-(Carbamoylmethylcarbamoyl)-4-(Diaminomethylideneamino)Butyl]Pyrrolidine-2-Carboxamide; Vasopressin Acetate
- CAS编号11000-17-2
- MFCD编号:MFCD03839092
- EINECS号:200-050-5
- 分子式:C46H65N13O12S2
- 分子量:1056.22
- 产品CID: 138698
- 产品分类原料药 → 激素及调节内分泌功能类药 → 垂体激素类药
物理性质
- 沸点°Cat760mmHg
- 闪点927.7 °C
- 密度3>1.31 g/ cm3
- PSA:505.74
- LogP:1.5091
- 溶解性Methanol (Slightly), Water (Slightly)
- 外观形态白色冻干粉末
- 储存条件室温
- 产品应用用于脑下垂体切除术后及颅脑外伤后的暂时性尿崩症,亦可作为可疑尿崩症的诊断性用药.不良反应和禁忌:注射后有恶心,呕吐,嗳气,腹痛等不良反应;冠心病,心力衰竭等禁用; 少数患者可发生荨麻疹,过敏性休克等不良反应.
- 性质描述为白色粉末,微臭,水溶液pH3.4-4.0,等电点为10.9,本品自牛,猪等动物脑下垂体后叶提取而得,从牛得到的为精加压素,从猪得到的是赖加压素,即第八位氨基酸不是精氨酸而是赖氨酸.本品有抗利尿和升高血压两种作用,抗利尿作用迅速,但维持时间仅2-8h,而升高血压时对心脏不利,一般临床不作升压药物.
合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2912110000-甲醛
2912120000-乙醛
2921211000-乙二胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-RE49961-E
优先权日:2016-10-21
标 题:Solid phase peptide syntheses
发明人：COLLINS JONATHAN M
权利人:CEM CORP
摘要:An improved method of deprotection in solid phase peptide synthesis is disclosed. In particular the deprotecting composition is added in high concentration and small volume to the mixture of the coupling solution, the growing peptide chain, and any excess activated acid from the preceding coupling cycle, and without any draining step between the coupling step of the previous cycle and the addition of the deprotection composition for the successive cycle. Thereafter, the ambient pressure in the vessel is reduced with a vacuum pull to remove the deprotecting composition without any draining step and without otherwise adversely affecting the remaining materials in the vessel or causing problems in subsequent steps in the SPPS cycle.
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📌 第三方产品分析报告
主要参考文献
1: Gizowski C, Trudel E, Bourque CW. Central and peripheral roles of vasopressin in the circadian defense of body hydration. Best Pract Res Clin Endocrinol Metab. 2017 Dec;31(6):535-546. doi: 10.1016/j.beem.2017.11.001. Epub 2017 Nov 13. Review. doi: 10.3389/fendo.2017.00308. eCollection 2017. Review.
3: Ishikawa SE. Is Exaggerated Release of Arginine Vasopressin an Endocrine Disorder? Pathophysiology and Treatment. J Clin Med. 2017 Oct 31;6(11). pii: E102. doi: 10.3390/jcm6110102. Review.
4: Caldwell HK, Aulino EA, Rodriguez KM, Witchey SK, Yaw AM. Social Context, Stress, Neuropsychiatric Disorders, and the Vasopressin 1b Receptor. Front Neurosci. 2017 Oct 16;11:567. doi: 10.3389/fnins.2017.00567. eCollection 2017. Review.
合成参考文献
参考文献:10.1111/j.1460-9568.2011.07761.x
摘要:Murakami G, Hunter RG, Fontaine C, Ribeiro A, Pfaff D. Relationships among estrogen receptor, oxytocin and vasopressin gene expression and social interaction in male mice. Eur J Neurosci. 2011 Aug;34(3):469–77. doi: 10.1111/j.1460-9568.2011.07761.x.
参考文献:10.1530/eje-11-0437
摘要:Secco A, Allegri AE, di Iorgi N, Napoli F, Calcagno A, Bertelli E, Olivieri I, Pala G, Parodi S, Gastaldi R, Rossi A, Maghnie M. Posterior pituitary (PP) evaluation in patients with anterior pituitary defect associated with ectopic PP and septo-optic dysplasia. Eur J Endocrinol. 2011 Sep;165(3):411–20. doi: 10.1530/eje-11-0437.
参考文献:10.1016/j.addbeh.2011.06.015
摘要:Guaderrama MM, Corwin EJ, Kapelewski CH, Klein LC. Sex differences in effects of cigarette smoking and 24-hr abstinence on plasma arginine vasopressin. Addict Behav. 2011 Nov;36(11):1106–9. doi: 10.1016/j.addbeh.2011.06.015.
参考文献:10.1016/j.ijcard.2005.01.043
摘要:Nakamura T, Funayama H, Yoshimura A, Tsuruya Y, Saito M, Kawakami M, Ishikawa S. Possible vascular role of increased plasma arginine vasopressin in congestive heart failure. International Journal of Cardiology. 2006 Jan;106(2):191–5. doi: 10.1016/j.ijcard.2005.01.043.
参考文献:10.1152/japplphysiol.01039.2005
摘要:Hinghofer-Szalkay HG, Rössler A, Evans JM, Stenger MB, Moore FB, Knapp CF. Circulatory galanin levels increase severalfold with intense orthostatic challenge in healthy humans. J Appl Physiol (1985). 2006 Mar;100(3):844–9. doi: 10.1152/japplphysiol.01039.2005.
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