CAS: 109-95-5; Ethyl Nitrite

上下游产品

diethyl ether 3-propenyl nitrite ethanol ethyl nitrate1,1-diphenyl-2-chloroethan-1-ol benzil 2-ethoxypyridine 2-hydroxyimino-propionaldehyde oxime

Triethyloxonium Fluoroborate置于nitrite体系中,用 水 用作溶剂,化学反应 0.67H,反应生成亚硝酸乙酯
参考文献:三氟四硼酸三烷基氧鎓烷基化水相后,无机阴离子物种的蒸气生成
标题:三氟四硼酸三烷基氧鎓烷基化水相后,无机阴离子物种的蒸气生成
摘要:三烷基氧鎓四氟硼酸盐的水相反应,R 3 ö + Bf 4-(r═me,等)已在简单无机阴离子基底,例如卤素离子,氰化物,硫氰酸盐,硫化物和几个含氧阴离子或它们相应的含氧酸的烷基化进行了测试.分离出气态产物并通过气相色谱质谱法(gc-Ms)鉴定.分别获得了碘化物,溴化物和氯化物的烷基化衍生物ri,Rbr和rcl,而对于氟化物,其向rf的转化效率非常低.Rcn和r 2获得了氰化物和硫化物的s,而硫氰酸盐得到的主要反应产物为rscn,其中含有少量烷基异硫氰酸盐rncs(<7%).在测试的含氧阴离子中,仅亚硝酸盐和硝酸盐分别以r-O-No和r-O-No 2的形式给出挥发性衍生物.反应通过添加et进行3 ö + Bf 4-的ch 2氯2中的反应产物的有机相至含水样品与萃取,未能确定其它不易挥发的反应产物.在4Ml反应瓶中(使用2毫升样品ť = 25oc),100μl的2M的et 3 ö + Bf
Doi:10.1021/ac900865D

专利信息

专利号:US-2023339906-A1
优先权日:2020-09-26
标 题 :A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof
发明人：SYTHANA SURESH KUMAR; NAGLE PRAMOD; KUMAR VIJAY KUMAR; KANAWADE SHRIKANT BHAUSAHEB; CHANDRE TUKARAM NIVRUTTI; THUBE VINAYAK KISAN; PATIL PRADEEP PRAKASH; SHUKLA SHALINI; SHENDE KANTILAL BALU; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD
摘要:The present invention discloses a process for the synthesis of compound of formula (VII) or a salt thereof,wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).

专利号:US-7452994-B2
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
发明人：MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN
权利人:ANORMED INC
摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

专利号:US-11649213-B2
优先权日:2018-09-26
标题 :Synthetic method for the preparation of a 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol compound
发明人：MEISENBACH MARK; MARTIN BENJAMIN; RONDE NIEK JOHANNES; RUIZ CARMEN
权利人:MEREO BIOPHARMA 1 LTD
摘要:Provided is a process for preparing a compound, comprising the steps of a) Reacting a compound of Formula A (Formula A) with the compound 3 (3) to provide the compound 5 (5) or a salt or solvate thereof, wherein R is a linear or branched C1-C5 alkyl. Further provided is the compound 5 or a salt or solvate thereof. (5) The use of these compounds in the synthesis of 3-[5-Amino-4-(3-Cyanobenzoyl)-Pyrazol-1-yl]-N-Cyclopropyl-4-Methylbenzamide is also provided.

专利号:US-4304934-A
优先权日:1980-12-30
标题 :Synthesis of amino hydroxy cyclopentenones
发明人：BARTELS-KEITH JAMES R; KARGER EVA R; ROGERS JEAN B
权利人:POLAROID CORP
摘要:This invention relates to a method of synthesizing 3-amino-2-hydroxy-2-cyclopentenones possessing an aliphatic substituent in the 4-position which comprises reacting cyanoacetamide with an aliphatic aldehyde to yield the corresponding β-substituted-α,α'-dicyanoglutaramide, hydrolyzing the amide to the corresponding β-substituted glutaric acid, esterifying the acid to the corresponding dialkyl diester, converting the diester to a 1,2-bis(trimethylsiloxy)-4-substituted cyclopentene by reductive cyclization using chlorotrimethylsilane in the presence of sodium, hydrolyzing and oxidizing the bis(trimethylsiloxy) compound to the 2-hydroxy-4-substituted-2-cyclopentenone in the presence of a cupric salt, nitrosating the 2-cyclopentenone to the 2-hydroxy-4-substituted-5-oximino-2-cyclopentenone, converting the oxime to the 2-acetoxy-3-amino-4-substituted-2-cyclopentenone by reductive acetylation and removing the acetyl group by alkanolysis to yield the 3-amino-2-hydroxy-4-substituted-2-cyclopentenone product.

专利号:US-3697597-A
优先权日:1968-09-21
标 题:Process for the preparation of alpha-oximinoalkyl ketones
发明人：DORLARS ALFONS
权利人:BAYER AG
摘要:Alpha -Oximino ketones, for example, oximinodipropyl ketone, are prepared by reacting a ketone in an inert organic solvent immiscible with water in the presence of a hydrogen halide with an amount of alkyl nitrite that is insufficient for complete nitrosation followed by extracting the ketone formed with an aqueous alkali solution, removing the alkaline extract formed and isolating the Alpha -oximino ketone. The ketones formed are useful as intermediates in the synthesis of pharmaceutical compounds, dyes, analytical reagents, plant protection agents, and optical brighteners.

专利号:US-9181203-B2
优先权日:2010-11-12
标题:Substituted pyrazino[2,3-d]isooxazoles as intermediates for the synthesis of substituted pyrazinecarbonitriles and substituted pyrazinecarboxamides
发明人：NAKAMURA KOUKI; MURAKAMI TAKESHI; NAITOU HIROYUKI; HANAKI NAOYUKI; WATANABE KATSUYUKI
权利人:FUJIFILM CORP; TOYAMA CHEMICAL CO LTD
摘要:The object of the present invention is to provide a compound which is useful as a production intermediate of pyrazine carboxamide derivative such as 6-fluoro-3-hydroxy-2-pyrazine carboxamide. The present invention provides a pyrazino[2,3-d]isoxazole derivative represented by the formula (I): n nwherein X represents a halogen atom, a hydroxyl group or a sulfamoyloxy group, and Y represents —C(â•?O)R or —CN; wherein R represents a hydrogen atom, an alkoxy group an aryloxy group, an alkyl group, an aryl group or an amino group.