CAS: 90905-33-2; 2-Methylpyrimidine-5-Carbaldehyde

相似化合物

5194-32-1 2239-83-0 5571-03-9

上下游产品

CAS号124-42-5 乙脒盐酸盐 | CAS号79-08-3 溴乙酸 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号2009-81-6 [3-(dimethylami... | CAS号1071435-99-8 1-(2-甲基嘧啶-5-基)乙胺 | CAS号2239-83-0 2-甲基-5-嘧啶甲醇

📜盐酸乙脒,2-Dimethylaminomethylene-1,3-Bis(Dimethylimmonio)Propane Bistetrafluoroborate置于sodium体系中,用 乙醇 作为反应溶剂,化学反应 5.0H,以10 G的收率获得产物2-甲基-5-嘧啶甲醛
参考文献:Benzamides
标题:Benzamides
摘要:本发明涉及含有抑制p2X7受体的苯甲酰胺类化合物.

专利信息

专利号:US-2024309003-A1
优先权日:2021-05-04
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN; PANDYA BHAUMIK; KAPLAN ALAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-12428425-B2
优先权日:2020-05-04
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：CZABANIUK LARA C; HOPPER TIMOTHY; HOUZE JONATHAN B; PANTELEEV JANE; RESCOURIO GWENAELLA; SANTORA VINCENT; WANG HAOXUAN; WHITE RYAN D; WONG ALICE R; WU YONGWEI; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN
权利人:AMGEN INC; VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-6764842-B2
优先权日:2001-03-28
标题 :Enantioselective bioreduction for the preparation of integrin receptor antagonist intermediates
发明人：STURR MICHAEL G; BOYD RUSSELL FIELDON; GBEWONYO KODZO; NTI-GYABAAH JOSEPH; POLLARD DAVID J; MCWILLIAMS JAMES CHRISTOPHER; TELARI KATHLEEN A
权利人:MERCK & CO INC
摘要:The present invention relates to a novel enantioselective bioreduction using a yeast microorganism for the preparation of the chiral allylic alcohols of structural formula I (R is hydrogen or methyl) which are useful in the asymmetric synthesis of integrin αvβ 3 receptor antagonists.

专利号:US-6410526-B1
优先权日:1999-06-02
标题 :αv integrin receptor antagonists
发明人：DUGGAN MARK E; HARTMAN GEORGE D; MEISSNER ROBERT S; PERKINS JAMES J
权利人:MERCK & CO INC
摘要:The present invention relates to novel nonanoic acid derivatives, their synthesis, and their use as alphav integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alphavbeta3 and alphavbeta5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, cancer, and metastatic tumor growth.

专利号:US-6413955-B1
优先权日:1999-10-04
标 题:Integrin receptor antagonists
发明人：ASKEW BEN C; SMITH GARRY R
权利人:MERCK & CO INC
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αvβ3 and/or αvβ5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammatory arthritis, cancer, and metastatic tumor growth.

专利号:US-9428490-B2
优先权日:2011-07-29
标 题 :Nuclear transport modulators and uses thereof
发明人：SANDANAYAKA VINCENT P; SHACHAM SHARON; KAUFFMAN MICHAEL; SHECHTER SHARON; MCCAULEY DILARA; LANDESMAN YOSEF; SENAPEDIS WILLIAM; SAINT-MARTIN JEAN-RICHARD
权利人:SANDANAYAKA VINCENT P; SHACHAM SHARON; KAUFFMAN MICHAEL; SHECHTER SHARON; MCCAULEY DILARA; LANDESMAN YOSEF; SENAPEDIS WILLIAM; SAINT-MARTIN JEAN-RICHARD; KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to nuclear transport modulators, e.g CRM1 inhibitors, and more particularly to a compound represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula (I), or a pharmaceutically acceptable salt or composition thereof, e.g, in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.