2'-甲氧基-4',6'-二甲基苯乙酮置于硫酸体系中,化学反应生成 3,5-二甲基苯甲醚 参考文献:Al-Ka'Bi,Ja'Far; Gore,Peter H.; Moonga,Baljit,Journal Of Chemical Research,Miniprint,1986,# 7,P. 2201-2226 标题:Al-Ka'Bi,Ja'Far; Gore,Peter H.; Moonga,Baljit,Journal Of Chemical Research,Miniprint,1986,# 7,P. 2201-2226
专利号:WO-2004009574-A1 优先权日:2002-07-22 标 题 :Synthesis of discodermolide 发明人:FLORENCE GORDON; KOCH GUIDO; LOISELEUR OLIVIER; MICKEL STUART JOHN; PATERSON IAN 权利人:NOVARTIS AG; NOVARTIS PHARMA GMBH; UNIV CAMBRIDGE TECH; FLORENCE GORDON; KOCH GUIDO; LOISELEUR OLIVIER; MICKEL STUART JOHN; PATERSON IAN 摘要:The invention relates to a process for preparing discodermolide, for preparing intermediates for the manufacture of discodermolide and discodermolide analogues and to the intermediates obtained during the process. Wherein the process proceeds via a tetraene of formula (IV).
专利号:US-7329769-B2 优先权日:2001-07-13 标 题:Catalytic boronate ester synthesis from boron reagents and hydrocarbons 发明人:SMITH III MILTON R 权利人:UNIV MICHIGAN STATE 摘要:A process for producing a ring-substituted arene borane which comprises reacting a ring-substituted arene with an HB organic compound in the presence of a catalytically effective amount of an iridium or rhodium complex with three or more substituents, excluding hydrogen, bonded to the iridium or rhodium and a phosphorus organic ligand, which is at least in part bonded to the iridium or rhodium, to form the ring-substituted arene borane. Also provided are catalytic compounds for catalyzing the process comprising an iridium or rhodium complex with three or substituents, excluding hydrogen, bonded to the iridium or rhodium and optionally, a phosphorus organic ligand, which is at least in part bonded to the iridium or rhodium.
专利号:US-10253004-B2 优先权日:2017-01-26 标 题:Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof 发明人:ECKHARDT MATTHIAS; WAGNER HOLGER; PETERS STEFAN 权利人:BOEHRINGER INGELHEIM INT 摘要:The present invention relates to compounds of formula I, n nwherein the groups R, R 1 , R 2 , R 3 , m and n are defined herein, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.
专利号:US-2006030702-A1 优先权日:2004-08-09 标 题:Synthesis of metal cyanines
专利号:US-9580409-B2 优先权日:2011-11-07 标 题:Modulators of opioid receptors and methods of use thereof 发明人:MALCOLM SCOTT; BOWEN CARRIE; MELNICK LAURENCE; XIE LINGHONG 权利人:SUNOVION PHARMACEUTICALS INC; SUNOVION PHARMACEUTICALS INC 摘要:Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as pain, neurological disorders, psychiatric disorders, and neuromuscular disorders. Compounds provided herein modulate the activity of opioid receptor (e.g., μ-opioid receptor) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.
专利号:WO-2005026142-A2 优先权日:2003-09-15 标题:Synthesis of alpha-tocopheryl alkanoates and precursors thereof
摘要:Li, D.-D.; Wang, G.-W., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 375. 摘要:Pandey, G.; Laha, R., Science of Synthesis: Photocatalysis in Organic Synthesis, (2018) 1, 160. 摘要:Clark, K. F.; Dimitrova, D.; Murphy, J. A., Science of Synthesis, (2020) , 69.