CAS: 717843-48-6; 3-Bromo-6-Methylpicolinonitrile

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CAS号31181-64-3 2-甲基-5-溴吡啶 N-氧化物 | CAS号7677-24-9 三甲基氰硅烷 | CAS号1620-75-3 2-氰基-6-甲基吡啶

5-溴-2-甲基吡啶置于三乙胺,间氯过氧苯甲酸体系中,用 二氯甲烷,乙腈 作为反应溶剂,化学反应 12.0H,反应生成 3-溴-6-甲基吡啶-2-甲腈
参考文献:一种天然产物(+/-)-依兰香碱的全合成及对映 异构体的拆分方法
标题:一种天然产物(+/-)-依兰香碱的全合成及对映 异构体的拆分方法
摘要:本发明公开了一种天然产物(+/-)‑依兰香碱的全合成及其对映异构体的手性拆分方法,属于有机合成技术领域.该方法中的天然产物(+/-)‑依兰香碱是在天然产物(+/-)‑一枝蒿碱g为底物通过四氢呋喃/甲基锂反应,得到天然产物(+/-)‑依兰香碱及其对映异构体,再用手性半制备型高效液相色谱仪,进行对应异构体的拆分,并且得到了依兰香碱及其对应异构体,总产率17.9%,本发明简化了合成方法,提高了全合成总产率,并对其进行结构鉴定,不仅解决了依兰香碱比旋光度上的分歧,还为此类化合物的进一步研究提供了基础和有力保障.

专利信息

专利号:WO-2023086799-A1
优先权日:2021-11-09
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:CN-108164461-A
优先权日:2018-02-12
标 题:A Total Synthesis of Natural Product (±)-Ylangylangine and Resolution Method of Enantiomers

专利号:CN-107129462-A
优先权日:2017-06-02
标 题:A kind of total synthesis of natural product (±) - a schizosine G and the separation method of enantiomers

专利号:CN-108164461-B
优先权日:2018-02-12
标题:A kind of total synthesis of natural product (±)-ylangenine and method for separation of enantiomers

专利号:CN-107129462-B
优先权日:2017-06-02
标题 :Total synthesis of a natural product (±)-artemisinine G and method for separating enantiomers