CAS: 518070-19-4; 3-Fluoro-5-Methylbenzoic Acid

上下游产品

3-氟-5-甲基苯甲酸甲酯 Methyl 3-Fluoro-5-Methylbenzoate 660416-38-6

3-氟-5-甲基苯甲酸甲酯置于lithium Hydroxide,水,盐酸体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 2.0H,以98%的收率获得产物3-氟-5-甲基苯甲酸
参考文献: "1,2,4"Oxadiazoles As Modulators Of Metabotropic Glutamate Receptor-5[fr] Nouveaux Composes
标题: "1,2,4"Oxadiazoles As Modulators Of Metabotropic Glutamate Receptor-5[fr] Nouveaux Composes

专利信息

专利号:US-9938278-B2
优先权日:2014-12-17
标题 :FXR (NR1H4) modulating compounds
发明人：GEGE CHRISTIAN; KREMOSER CLAUS; KINZEL OLAF; BLOMGREN PETER A; CURRIE KEVIN S; KROPF JEFFREY E; SCHMITT AARON C; WATKINS WILLIAM J; XU JIANJUN
权利人:GILEAD SCIENCES INC
摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:US-10233182-B2
优先权日:2014-04-04
标题 :Substituted spirocyclic inhibitors of autotaxin
发明人：BABISS LEE; CLARK MATTHEW; KEEFE ANTHONY D; MULVIHILL MARK J; NI HAIHONG; RENZETTI LOUIS; RUEBSAM FRANK; WANG CE; XIE ZHIFENG; ZHANG YING
权利人:X RX INC
摘要:The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.