CAS: 496-69-5; 2-Bromo-4-Fluorophenol

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CAS号371-41-5 4-氟苯酚 | CAS号452-08-4 2-溴-4-氟苯甲醚 | CAS号371-40-4 4-氟苯胺 | CAS号98-54-4 对叔丁基苯酚 | CAS号452-08-4 2-溴-4-氟苯甲醚 | CAS号347-54-6 5-氟水杨醛 | CAS号253429-18-4 2-溴-1-(2,2-二乙氧基... | CAS号84478-87-5 2-溴-4-氟-5-硝基苯酚 | CAS号850568-00-2 4-氟-2-羟基苯基硼酸 | CAS号653-92-9 2-溴-4-氟苯甲酸甲酯 | CAS号326-69-2 2-溴-1-乙氧基-4-氟苯 | CAS号178546-34-4 3-溴-5-氟-2-羟基苯甲醛 | CAS号1218-82-2 6-氟黄酮 | CAS号1426675-86-6 2-benzylidene-5...

4-氟苯酚置于ammonium Metavanadate,Aluminum Tri-Bromide,氧气体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 8.0H,以95%的收率获得产物2-溴-4-氟苯酚
参考文献:布朗斯台德酸或路易斯酸促进的钒催化氧化溴化反应
标题:布朗斯台德酸或路易斯酸促进的钒催化氧化溴化反应
摘要:芳烃的氧化溴化反应是在分子氧下,在溴化物盐和布朗斯台德酸或路易斯酸存在下,由钒催化剂诱导的,与传统的溴化溴化方法相比,该方法提供了一种环保的溴化方法.这种催化反应可以适用于烯烃和炔烃的溴化,得到相应的vic-溴化物.已证明使用卤化铝代替布朗斯台德酸作为路易斯酸可为氧化溴化提供更实用的方法.从酮中获得α-溴化产物.发现albr 3既是溴化物源又是路易斯酸,可以顺利地诱导溴化.511 H NMR实验表明,这种催化溴化反应可能取决于分子氧下钒催化剂的氧化还原循环.
DOI:10.1016/j.Tet.2010.06.042

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-12384803-B2
优先权日:2020-02-24
标 题:Non-cryogenic synthesis of heteroatom-bridge precursors of metal-ligand complex catalysts
发明人：DO HIEN Q; FONTAINE PHILIP P; KRASOVSKIY ARKADY L; SPENCER LIAM P; OGAWA KELLI A; LESNIEWSKI DANIEL K; ANDERSON RUSSELL W
权利人:DOW GLOBAL TECHNOLOGIES LLC
摘要:Embodiments are directed to a metal-ligand complex catalyst precursor, (L1)(L2)X(R1)(R2), and methods for producing the same from a compound of formula Q2X(R1)(R2). L1 and L2 are independently —R3—Z1 or —R4—Z1. R1 and R2 are independently selected from a hydrogen atom, (C1-C40)hydrocarbyl and, optionally, R1 and R2 are connected to form a ring having from 3 to 50 atoms in the ring, excluding hydrogen atoms. X is Si, Ge, Sn, or Pb. Each Q is independently Ar1—Y1R3— or Ar2—Y2—R4—. R3 and R4 are independently selected from —(CRC2)m—, where m is 1 or 2, and where each RC is independently selected from the group consisting of (C1-C40)hydrocarbyl, (C1-C40)heterohydrocarbyl, and —H. Y1 and Y2 are independently S, Se, or Te. Ar1 and Ar2 are independently (C6-C50)aryl. Ar1—Y1—R3— and Ar2—Y2—R4— are not identical. Each Z1 is independently selected from Cl, Br, and I.

专利号:US-9090922-B2
优先权日:2010-11-30
标题:Process for the preparation of nebivolol
发明人：MAURO SANDRO; FATTORI DANIELA; D ANDREA PIERO; CIPOLLONE AMALIA; D ANDREA ENZO; ERCOLANO CARMELA
权利人:MAURO SANDRO; FATTORI DANIELA; D ANDREA PIERO; CIPOLLONE AMALIA; D ANDREA ENZO; ERCOLANO CARMELA; MENARINI INT OPERATIONS LU SA
摘要:The present invention relates to a novel process for the synthesis of the Nebivolol product depicted in Scheme 1, comprised of a reduced number of high-yield steps, and characterized by the enzymatic resolution of the chroman ester precursor.

专利号:US-2009099200-A1
优先权日:2005-06-09
标题 :Azacyclohexane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LI CHUN SING; RAMTOHUL YEEMAN K; HUANG ZHENG; LACHANCE NICOLAS
权利人:LI CHUN SING; RAMTOHUL YEEMAN K; HUANG ZHENG; LACHANCE NICOLAS
摘要:Azacyclohexane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-7405310-B2
优先权日:2001-03-05
标 题:Non-nucleoside reverse transcriptase inhibitors
发明人：LINDSTROM STEFAN; SAHLBERG CHRISTER; WALLBERG HANS; KALYANOV GENAIDY; ODEN LOURDES SALVADOR; NAESLUND LOTTA
权利人:MEDIVIR AB
摘要:This invention relates to non-nucleoside reverse transcriptase inhibitors active against HIV-1 and having an improved resistance and pharmacokinetic profile. The invention further relates to novel intermediates in the synthesis of such compounds and the use of the compounds in antiviral methods and compositions.

专利号:EP-4110787-B1
优先权日:2020-02-24
标 题:Non-cryogenic synthesis of heteroatom-bridge precursors of metal-ligand complex catalysts