CAS: 4885-02-3; Dichloro(Methoxy)Methane

上下游产品

Methyl formate 3-chloro-3-methoxy-diazirine chlorine chloromethyl methyl ether 4-Chlorobutanoyl chloride Methyl formate succinoyl dichloride Adipic acid dichloride

甲酸甲酯置于草酰氯,N-甲基甲酰苯胺体系中,化学反应生成 1,1-二氯甲醚
参考文献:含氟芳烃与二氯甲基烷基醚的直接甲酰化.
标题:含氟芳烃与二氯甲基烷基醚的直接甲酰化.
摘要:研发了含氟芳族化合物与二氯甲基烷基醚的甲酰化.已经将二氯甲基丙基醚和二氯甲基丁基醚用于含氟的甲磺酸酯的甲酰化,以非常好的收率获得产物相应的醛.这些醚的使用要比由挥发性甲酸甲酯制得的甲基醚要好.含氟苯酚与这些二氯甲基烷基醚的反应未得到水杨醛衍生物,而是导致了相应的芳基甲酸酯的高收率.讨论了一个合理的机制.
DOI:10.1248/cpb.C19-00176

专利信息

专利号:US-4288608-A
优先权日:1978-06-01
标题:Synthesis of anthracyclines
发明人：JOHNSON FRANCIS; KIM KYOUNG S
权利人:RESEARCH CORP
摘要:There is provided a novel method of synthesizing certain heterocyclic quinones. In particular there is provided a novel and regiospecific synthesis of 9-acetyl-6,11-dihydroxy-4-methoxy-7,8,9,10-tetrahydronaphthacene-5,12-quinone (7,9-dideoxydaunomycinone) which is known intermediate in the synthesis of daunomycinone. There is also provided a method of preparing analogs of 7,9-dideoxydaunomycinone which thus provide for the preparation of known and desired analogs of daunomycinone. Daunomycinone is a known compound which is an intermediate in the preparation of the clinically accepted naturally-occurring antitumor antibiotics daunomycin and its derivitive adriamycin.

专利号:US-9403841-B2
优先权日:2012-01-25
标题:Phragamalin limonoids for the treatment of sexual dysfunction
发明人：WIKBERG JARL; JIRGENSONS AIGARS; LIEPINSH EDVARDS
权利人:DICOTYLEDON AB
摘要:The present invention relates to novel chemical compounds, to methods for synthesis of such compounds, and to the use of these novel compounds in the synthesis of other chemical compounds that, inter alia, may be used in the treatment of sexual dysfunction, and for eliciting enhancing effects on sexual behavior. The invention also relates to remarkable biological properties of the novel compounds in their capacity of inducing aggressive behavior.

专利号:US-9464021-B2
优先权日:2013-11-01
标题 :Method of preparation of stereospecific quinone derivatives
发明人：MEHTA DILIP S; MOHAN PRIYA; SHASTRI MAYANK; REID TED
权利人:MEHTA DILIP S; MOHAN PRIYA; SHASTRI MAYANK; REID TED
摘要:The description provides processes for the regio and stereospecific synthesis of polyprenylatedquinone derivatives, such as Vitamin K1, K2 and Ubiquinone, exploiting dithioacetals, especially 1,3-dithiane, mediated Umpolung chemistry which works along a new concept “Inhibiting resonance delocalization (IRD)â€? to overcome isomerization generated due to delocalization of allyliccarbanion on the Ï€-electron cloud of an allylic systems by the conventional synthesis.

专利号:US-4460501-A
优先权日:1983-08-30
标题 :Process for the synthesis of peptides utilizing thioxanthylmethyloxycarbonyl dioxides
发明人：CARPINO LOUIS A; SEGEV DAVID
权利人:RESEARCH CORP
摘要:A composition of the formula: ##STR1## wherein X is lower alkyl, and Z is an amino acid a peptide residue or a good leaving group, the composition is adaptable as a blocking or protecting group for an amine composition useful in peptide synthesis and a method of protecting an amino group of an organic molecule during a reaction which modifies a portion of the molecule other than the protected amino group.

专利号:US-2009143426-A1
优先权日:2007-12-04
标 题:Synthesis of 1,3,6-trisubstituted-2-carboxyquinol-4-ones as selective ET A antagonists and their use as medicaments
发明人：STEPHANI RALPH ANTHONY; PATEL HARDIK JITENDRA; REZNIK SANDRA EVE; CANTOR JEROME OWEN
权利人:STEPHANI RALPH ANTHONY; PATEL HARDIK JITENDRA; REZNIK SANDRA EVE; CANTOR JEROME OWEN
摘要:The invention discloses the composition and preparation of various 1,3,6-trisubstituted-2-carboxy-quinol-4-ones of the formula 1 where R is H, alkyl, haloalkyl or hydroxyalkyl, R′ is alkyl, nitro, halogen or NR 2 ′″ where R′″ is alkyl or cycloalkyl, and R″ is H or alkyl. The composition of the invented compounds as methods of antagonizing the action of endothelin-1 to treat cardiovascular, pulmonary diseases and obstetric disorders and preterm labor and preeclampsia in mammals is disclosed.

专利号:US-6147217-A
优先权日:1997-02-04
标题:Synthesis of terfenadine and derivatives
发明人：SENANAYAKE CHRIS HUGH; FANG QUN KEVIN; WILKINSON SCOTT HAROLD
权利人:SEPRACOR INC
摘要:Processes for preparing compounds having the general formula: ##STR1## wherein R 1a is protected carboxy, carboxy, hydroxymethyl, protected hydroxymethyl, or methyl are disclosed. Processes of the invention begin with a starting material of the general formula IV ##STR2## wherein R 1 and R 2 are as defined in the specification.