专利号:US-10040752-B2 优先权日:2015-08-24 标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof 发明人:MKRTCHYAN GNEL; YAO QINGWEI 权利人:CODY LABORATORIES INC 摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.
专利号:US-2010267988-A1 优先权日:2006-06-08 标 题:Processes for preparing intermediate compounds useful for the preparation of cinacalcet 发明人:SZEKERES TIBOR; REPASI JOZSEF; SZABO ANDRAS; MANGION BERNARDINO 权利人:MEDICHEM SA 摘要:The invention relates, in general, to an improved process for preparing compounds (e.g., 3-(3-trifluoromethylphenyl)propanal (Compound III, below)), which are key intermediates for the synthesis of cinacalcet, its salts and/or solvates thereof, as well as the use of such compounds prepared by such process for the preparation of cinacalcet and/or its salts or solvates.
专利号:US-2008319229-A1 优先权日:2007-06-22 标题 :process for the preparation of cinacalcet 发明人:ALLEGRINI PIETRO; ATTOLINO EMANUELE 权利人:DIPHARMA FRANCIS SRL 摘要:The invention provides a novel process for the preparation of a compound of formula (I) n n n n n n n n n n n n which includes the reduction of a compound of formula (II) or a salt thereof, in the presence of a catalyst, n n n n n n n n n n n n n n n n and novel intermediates useful for its synthesis.
专利号:US-2019002394-A1 优先权日:2015-08-24 标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
专利号:US-4358606-A 优先权日:1981-06-19 标 题:Esters of phenalkyloxycarbonylamino acids 发明人:LEE SHY-FUH; HENRICK CLIVE A 权利人:ZOECON CORP 摘要:Novel esters of phenylalkyloxy- or phenylalkylthioacylamino acids and pyridylalkyloxy- or pyridylalkylthioacylamino acids, synthesis thereof, intermediates therefor, and the use of said esters for the control of weeds.
专利号:US-8940855-B2 优先权日:2009-06-02 标题:Polymers bearing pendant pentafluorophenyl ester groups, and methods of synthesis and functionalization thereof 发明人:HEDRICK JAMES L; NELSON ALSHAKIM; SANDERS DANIEL P 权利人:IBM 摘要:A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl ester group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl ester group. Using a suitable nucleophile, the pendant pentafluorophenyl ester group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.
[参考文献]: Shirley H Lomeli, Et Al. New Reagents For Increasing Esi Multiple Charging Of Proteins And Protein Complexes. J Am Soc Mass Spectrom. 2010 Jan;21(1):127-31.
合成参考文献
摘要:Hollmann, F., Science of Synthesis Knowledge Updates, (2021) 3, 437. 摘要:Steinfeldt, N.; Junge, K., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 2, 36.