专利号:WO-2024103123-A1 优先权日:2022-11-17 标题 :The synthesis of omapatrilat 发明人:VITALE ROMINA; MARTIN VINCENT ALEXANDRE; FABER WIJNAND; SOMMER ROMAN 权利人:ENDOTHELIUM SCANNING NANOTECHNOLOGY LTD 摘要:Described herein are improved methods of making Compound 1 (4S,7S,10aS)-4-((S)-2- mercapto-3-phenylpropanamido)-5-oxooctahydro-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid, or Omapatrilat, and purified Omapatrilat obtained from the improved methods.
专利号:WO-8404041-A1 优先权日:1983-04-14 标 题 :Colon-specific drug delivery system 发明人:FRIEND DAVID ROBERT; CHANG GEORGE WASHINGTON 权利人:UNIV CALIFORNIA 摘要:A colon-specific drug delivery system based on the use of a synthetic drug glycoside prodrug composition which, when ingested by a mammal, undergoes reaction with glycosidases produced by colonic microflora to release a free drug capable of being absorbed to or absorbed by the colonic mucosa. Synthesis of synthetic drug glycosides useful in the present drug delivery system is illustrated in figure 1. In that figure, 'a' is Ag2CO3, molecular sieve, CCl4; 'b' is 0.01 N NaOH, MeOH; and 'c' is betaglucosidase; the numerals 3, 4, 23, 14, 15, 1 and 2 denote compounds 3, 4, 23, 14, 15, 1 and 2 respectively; the letter R means radical and the letters Ac mean acetyl. The other letters, e.g., O, H, F and Br denote the chemical elements oxygen, hydrogen, fluorine and bromine, respectively.
专利号:EP-4619408-A1 优先权日:2022-11-17 标题 :The synthesis of omapatrilat
专利号:RU-2238974-C2 优先权日:2001-09-06 标题:Dna fragment of mycelial fungus penicillium verruculosum encoding synthesis of secretable endoglucanase iii and group of penicillium canescens strains producing penicillium verruculosum endoglucanase iii constructed by methods of transformation and genetic engineering based on this dna fragment
参考标题:Synthesis Of Complex Oligosaccharides By Using A Mutated (1,3)--D-Glucan Endohydrolase From Barley 作者:Jon K. Fairweather,Maria Hrmova,Simon J. Rutten,Geoffrey B. Fincher,Hugues Driguez |发布日期:2003.6.6 摘要:Complex Oligosaccharides With Newly Formed (1,3)-Beta-Glycosidic Linkages Were Obtained In Good To Excellent Yields When Substituted Or Unsubstituted Alpha-Laminaribiosyl Fluorides, Acting As Donors, Were Condensed Onto Mono- And Disaccharide Beta-D-Hexopyranoside Acceptors By Using A (1,3)-Beta-D-Glycosynthase. These Linear And Branched (1,3)-Beta-Linked Oligosaccharides Could Prove To Be Important
合成参考文献
参考文献:10.1080/00021369.1991.10870897|10.1271/bbb1961.55.1959 摘要:Haga K, Kitaoka M, Kashiwagi Y, Sasaki T, Taniguchi H. Purification and Properties of a Xylanase fromCellvibrio gilvusThat Hydrolyzesp-Nitrophenyl Cellooligosaccharides. Agricultural and Biological Chemistry. 1991 Aug;55(8):1959–67. doi: 10.1080/00021369.1991.10870897.