专利号:US-9212118-B2 优先权日:2010-12-23 标题:Synthesis of intermediates for preparing anacetrapib and derivatives thereof 发明人:HUMLJAN JAN; MARAS NENAD 权利人:HUMLJAN JAN; MARAS NENAD; LEK PHARMACEUTICALS 摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.
专利号:US-11059835-B2 优先权日:2014-08-15 标 题 :Synthesis of cephalosporin compounds 发明人:WALLER DAVID; GAZDA GREGORY; MINDEN ZACHARY; BARTON LISA; LEIGH CLIFTON 权利人:MERCK SHARP & DOHME 摘要:Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction.
专利号:US-7256197-B2 优先权日:2001-10-12 标 题 :Methods for synthesis of diarylmethanes 发明人:ROSOWSKY ANDRE; CHEN HAN 权利人:DANA FARBER CANCER INST INC 摘要:The present invention relates to dihydrofolate reductase inhibitors having an aromatic group and a heteroaromatic group linked by a methylene group; methods of preparation of dihydrofolate reductase inhibitors that include metal mediated cross coupling of an aromatic halide or heteroaromatic halide with an organozinc reagent; and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such dihydrofolate reductase inhibitors.
专利号:US-2024010638-A1 优先权日:2020-11-13 标题:Improved synthesis of crac channel inhibitors 发明人:STAUDERMAN KENNETH; DUNN MICHAEL; OLMSTEAD KAY 权利人:CALCIMEDICA INC 摘要:Provided herein is an improved synthetic method for the production of CRAC channel inhibitors. The synthetic method provides a method for producing highly pure CRAC channel inhibitors for clinical testing.
专利号:US-10457640-B2 优先权日:2016-10-19 标 题:Synthesis of inhibitors of EZH2 发明人:VASWANI RISHI G; HEWITT MICHAEL CHARLES 权利人:CONSTELLATION PHARMACEUTICALS INC 摘要:Provided herein are synthetic methods for the preparation of EZH2 inhibitors.
专利号:US-4256649-A 优先权日:1977-10-20 标 题:Synthesis of olefinic oxides from olefin and oxygen 发明人:DYER PAUL N 权利人:AIR PROD & CHEM 摘要:Propylene oxide and other olefinic oxides are synthesized by reacting an olefin and oxygen in the presence of a catalytic amount of a complex. The complex is of the type L 2 MX 2 , L 2 M or L 2 MR where M is palladium, X is an acidic anion (preferably chloride); R is an olefinic group (preferably a propylene group) and L 2 consists of two monodentate ligands or a single bidentate ligand. n L 2 : n (a) is resistant to oxidation under the conditions of the process; n (b) is of the type AR 1 R 2 R 3 or R 4 R 5 AR 6 AR 7 R 8 where A is phosphorous or arsenic and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are as defined herein; n (c) (in the case of a monodentate ligand) has a cone angle not less than 170° when A is phosphorous and has a cone angle not less than 142° when A is arsenic; or n (d) in the case of a bidentate ligand) the monodentate equivalent of each part of the bidentate ligand has a cone angle of not less than 170° when A is phosphorous and of not less than 142° when A is arsenic. n Increased yields of olefinic oxide may be obtained by the introduction of hydrogen.