5-氟-2-甲基苯甲酸置于硫酸体系中,用 甲醇 用作溶剂,以78%的收率获得5-氟-2-甲基苯甲酸甲酯 参考文献:Methods Of Making 2,6-Diaryl Piperidine Derivatives 标题:Methods Of Making 2,6-Diaryl Piperidine Derivatives 摘要:描述了制备2,6-二芳基哌啶衍生物的方法.更具体地,通过芳基或杂环芳基醛与1,3-乙二酸二甲酯进行环缩合反应制备具有1-4式的2,6-二芳基哌啶.
专利号:US-6992097-B2 优先权日:1998-08-18 标 题 :Growth hormone secretagogues 发明人:HAUSER KENNETH LEE; DODGE JEFFREY ALAN; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR III CHARLES WILLIS; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROGER LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE 权利人:LILLY CO ELI 摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.