CAS: 1660-94-2; Tetraethyl Methylenebis(Phosphonate)

相似化合物

1660-95-3 16001-93-7 37465-31-9

上下游产品

diethyl chloromethylphosphonate sodium diethyl phosphite diethyl iodomethanephosphonate triethyl phosphiteMethylenediphosphonic acid P,P'-methanediyl-bis-phosphonic acid tetrachlorideP,P'-methanediyl-bis-phosphonic acid tetrachloride (dichloromethylene)bisphosphonic acid, tetraethyl ester bisphosphonatetetraethyl(p-chlorophenyl)vinylidenebisphosphonate

亚磷酸二乙酯置于sodium体系中,用 二氯甲烷 用作溶剂,化学反应 336.0H,以58%的收率获得亚甲基二磷酸四乙酯
参考文献:通过使用四乙基亚甲基双膦酸对 α,β-不饱和醛进行 Horner-Wadsworth-Emmons 烯烃化反应,有效且简便地获得取代的 1E,3E-二烯基膦酸酯
标题:通过使用四乙基亚甲基双膦酸对 α,β-不饱和醛进行 Horner-Wadsworth-Emmons 烯烃化反应,有效且简便地获得取代的 1E,3E-二烯基膦酸酯
摘要:通过 α,β-不饱和醛与亚甲基双膦酸四乙酯的 Horner-Wadsworth-Emmons 烯化,在非均相介质中,在固体碳酸钾存在下,开发了一种操作简单且高产的 1E,3E-二烯基膦酸酯合成方法.回流 Dmf.
Doi:10.1246/cl.180149

专利信息

专利号:US-5338851-A
优先权日:1993-03-31
标 题:Synthesis of cis-decahydroisoquinoline-3-carboxylic acids
发明人：HUFF BRET E; KHAU VIEN V; MARTINELLI MICHAEL J; PETERSON BARRY C
权利人:LILLY CO ELI
摘要:This invention provides a process for the synthesis of cis-decahydroisoquinoline-3-carboxylic acids and provides intermediates in the synthesis thereof.

专利号:US-7888337-B2
优先权日:2007-08-31
标 题 :Synthesis of oseltamivir containing phosphonate congeners with anti-influenza activity
发明人：WONG CHI-HUEY; FANG JIM-MIN; SHIE JIUN-JIE; CHENG YIH-SHYUN EDMOND; JAN JIA-TSRONG
权利人:ACADEMIA SINICA
摘要:Novel phosphonate compounds are described. The compounds have activity as neuraminidase inhibitors against wild-type and H274Y mutant of H1N1 and H5N1 viruses. The present disclosure also provides an enantioselective synthetic route to known neuraminidase inhibitors oseltamivir and the anti-flu drug Tamiflu®, as well as novel phosphonate compounds, via D-xylose. Another efficient and flexible synthesis of Tamiflu and the highly potent neuraminidase inhibitor Tamiphosphor was also achieved in 11 steps and >20% overall yields from the readily available fermentation product (1S-cis)-3-bromo-3,5 -cyclohexadiene-1,2-diol. Most of the reaction intermediates were obtained as crystals without tedious purification procedures. The key transformations include an initial regio- and stereoselective bromoamidation of a bromoarene cis-dihydrodiol, as well as the final palladium-catalyzed carbonylation and phosphonylation.

专利号:US-5461156-A
优先权日:1993-03-31
标 题 :Stereocontrolled synthesis of cis-bicyclic compounds
发明人：KHAU VIEN V; MARTINELLI MICHAEL J; PETERSON BARRY C; SULLIVAN KEVIN A
权利人:LILLY CO ELI
摘要:This invention provides a process for the stereocontrolled synthesis of cis-bicyclic compounds, including cis-hexahydro-6-isoquinolones, cis-dihydroisochromanones, cis-dihydrothiochromanones, and cisbicyclo[4.4.0]dec-3-ene-2-ones.

专利号:US-3624188-A
优先权日:1968-10-25
标题 :Hypohalogenation of tetramethyl and tetraethyl methylenediphosphonates and trihydrocarbyl phosphonoacetates
发明人：CURRY JOHN DOWNING
权利人:PROCTER & GAMBLE
摘要:The process of reacting either (1) a tetraalkyl (methyl, ethyl, halomethyl or haloethyl) methylenediphosphonate or (2) a trihydrocarbyl (C2-C4) phosphonoacetate with a hypohalite in an aqueous electrolyte solution (preferably in the presence of an inert, water-immiscible, organic solvent) to produce the corresponding mono- and di-halogenated methylenediphosphonate and phosphonoacetate esters. These esters have utility as intermediates in the synthesis of detergent builders and as extreme pressure additives for lubricant compositions.

专利号:US-5442085-A
优先权日:1992-12-04
标 题:Synthesis of tetraalkyl vinylidene diphosphonate monomer
发明人：ALEXANDRATOS SPIRO D
权利人:UNIV TENNESSEE RES CORP
摘要:A method of making a monomer of tetraalkyl vinylidene-1, 1-diphosphonate. The monomer is manufactured by combining an aqueous secondary amine solution with a formaldehyde and a tetra (alkyl) methylene diphosphonate. The resulting mixture is maintained at a pH above about 6 and refluxed for two hours to enable reaction to produce the monomer of tetraalkyl vinylidene-1, 1-diphosphonate. The product monomer is then purified to produce the final end product.

专利号:WO-2021083438-A1
优先权日:2019-10-30
标 题:Inhibitors of purine nucleoside phosphorylase - synthesis and use thereof for treatment of t-cell acute lymphoblastic leukemia and lymphoma
发明人：SKACEL JAN; JANEBA ZLATKO; MERTLIKOVA KAISEROVA HELENA
权利人:USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I
摘要:The present invention relates to new compounds of general formula I, their synthesis, their pharmaceutically acceptable salts, and their use in treatment of T-cell acute lymphoblastic leukemia and lymphoma.