CAS: 15722-48-2; 5,5'-(Diazene-1,2-Diyl)Bis(2-Hydroxybenzoic Acid)

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CAS号89-57-6 5-氨基水杨酸 | CAS号69-72-7 水杨酸 | CAS号119-36-8 水杨酸甲酯 | CAS号2516-96-3 2-氯-5-硝基苯甲酸 | CAS号62773-65-3 ethyl 5-amino-2... | CAS号89-57-6 5-氨基水杨酸

Olsalazine Methyl Ester置于水,Sodium Hydroxide体系中,化学反应 2.0H,以97.6%的收率获得奥沙拉嗪
参考文献:Ph引发的奥沙拉嗪释放的钙配位固体
标题:Ph引发的奥沙拉嗪释放的钙配位固体
摘要:内脏反应:Olsalazine,一种用于治疗溃疡性结肠炎的抗炎药,可能会引起小肠内早期释放而引起的副作用.为了减轻这种情况,合成了奥沙拉嗪钙络合物固体,该固体在低ph下可抵抗溶解,并在中性ph下逐渐释放奥沙拉嗪.钙物质的溶解速度也比市售钠盐慢,这使其成为改善奥沙拉嗪向结肠输送的潜在候选药物.
Doi:10.1002/cmdc.201700540

专利信息

专利号:US-8546532-B2
优先权日:2008-04-17
标题:Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
发明人：BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS
权利人:BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS; DECLION PHARMACEUTICALS INC
摘要:The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.

专利号:US-2013035307-A1
优先权日:2010-01-26
标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
发明人：PRESTWICH GLENN D; KENNEDY THOMAS P
权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P
摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.

专利号:US-2024287041-A1
优先权日:2021-05-20
标题 :Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
发明人：BALOGLU ERKAN; AUSTAD BRIAN C; ROE DAVID G; KEDUC ANDREW; GOTTSCHLING STEPHEN EDMUND; HECKER EVAN
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The present invention relates to a method of preparing a compound represented by structural formula (VII), comprising reacting a compound represented by structural formula (II), with a compound represented by structural formula (III), in a solvent, in the presence of a Pd catalyst and one or more inorganic bases under conditions suitable to prepare a compound represented by structural formula (VII): The values and example values of the variables in structural formulas (VII), (II), and (III) are defined herein. The present invention also relates to crystalline Forms I and II of the compound represented by Structural Formula (VII), the use of the crystalline Forms in treating disease or disorders associated with CRM1 and method of preparing the crystalline Forms.

专利号:US-7411031-B2
优先权日:2001-11-23
标 题 :Synthesis of polyanhydrides
发明人：UHRICH KATHRYN E; SCHMELTZER ROBERT C; ANASTASIOU THEODORE JAMES
权利人:UNIV RUTGERS
摘要:The present invention provides a method for forming compounds of Formulan nHO—C(â•?O)R 1 —X—R 2 —X—R 1 —C(â•?O)—O—Hn nwherein compound (I) can be polymerized to provide a polymer that contains therapeutically active compounds. In the compounds of the invention, each R 1 is group that will provide the therapeutically active compound upon hydrolysis of the polymer; each X is independently an ester linkage or an amide linkage; and R 2 is a linking group.

专利号:US-8754197-B2
优先权日:2004-07-07
标题:Synthesis of azo bonded immunoregulatory compounds
发明人：RIGGS-SAUTHIER JENNIFER A; EKWURIBE NNOCHIRI N
权利人:RIGGS-SAUTHIER JENNIFER A; EKWURIBE NNOCHIRI N; BIOCON LTD
摘要:Methods are disclosed for preparing compounds of Formula I: n nwhere R 1 , R 3 , and R 4 are independently hydrogen or C 1 to C 4 alkyl, and R 2 is:n n nwhere R 5 is selected from the group consisting of hydrogen and C 1 to C 4 alkyl, orn n nwhere R 6 , R 7 and R 8 are independently hydrogen or C 1 to C 4 alkyl; or the esters or pharmacologically acceptable salts thereof. The compounds and or their metabolites can be used to treat or prevent various diseases, particularly inflammatory conditions of the GI tract.

专利号:US-7309799-B2
优先权日:2004-06-01
标 题:Methods for the synthesis of milnacipran and congeners thereof
发明人：BUCHWALD STEPHEN L; SWAGER TIMOTHY M; RARIY ROMAN V
权利人:COLLEGIUM PHARMACEUTICAL INC
摘要:One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.