CAS: 14205-39-1; Methyl 3-Aminobut-2-Enoate

相似化合物

13412-12-9 14205-39-1 80012-11-9

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CAS号105-45-3 乙酰乙酸甲酯 | CAS号7664-41-7 氨 | CAS号6372-01-6 (E)-methyl 3-ch... | CAS号39562-70-4 尼群地平 | CAS号21881-77-6 间-硝苯地平 | CAS号21829-28-7 3,5-Pyridinedic... | CAS号22260-83-9 4-甲基-2-苯基-1,3-噁... | CAS号205999-88-8 methyl 4-(4-chl... | CAS号223788-08-7 2-甲基-6-氧代-1,6-二... | CAS号21731-17-9 β-氨基巴豆酸甲酯 | CAS号88150-46-3 3-O-ethyl 5-O-m... | CAS号89226-50-6 马尼地平 | CAS号88150-62-3 邻苯二甲酰基氨氯地平

乙酰乙酸甲酯置于ammonium Acetate体系中,用 甲醇 用作溶剂,化学反应 3.0H,反应生成3-氨基巴豆酸甲酯
参考文献:铜催化β-(酰基氨基)丙烯酸酯的1,4-还原不对称合成β-氨基酸衍生物
标题:铜催化β-(酰基氨基)丙烯酸酯的1,4-还原不对称合成β-氨基酸衍生物
摘要:已经建立了一套新的反应条件,以促进铜催化的β-(酰基氨基)丙烯酸酯的1,4-还原,以高收率和均一的ee值向β-烷基-β-氨基酸衍生物的选择(最多99%),无论使用(e)-或(z)-底物.
Doi:10.1021/ol200287Z

专利信息

专利号:WO-2011130852-A1
优先权日:2010-04-21
标题:Preparation of intermediates for the synthesis of dihydropyridine calcium channel blockers
发明人：SOUZA FABIO; PAN MING
权利人:ALPHORA RES INC; SOUZA FABIO; PAN MING
摘要:4- (2,3- dichlorophenyl) -1,4- dihydro- 2,6- dimethyl- 5- methoxycarbonyl- 3- pyridinecarboxylic acid, a key intermediate in the synthesis of the cardiovascular calcium channel blocker drug 3-butanoyloxymethoxycarbonyl-5- methoxycarbonyl-4- (2,3-dichlorophenyl) -2,6- dimethyl-1,4- dihydropyridine, of purity greater than 97% and essentially free of the corresponding diacid, is prepared by a process involving selective precipitation of its carboxylate via addition of concentrated solutions of alkali metal salts. Similar intermediate mono-carboxylic acids useful in the synthesis of other unsymmetrically substituted dihydropyrine drugs such as nisoldipine, nitrendipine and nimodipine can be similarly prepared and purified.

专利号:US-6603006-B2
优先权日:1998-10-26
标题:Intermediate for the synthesis of amlodipine, a process for the preparation thereof and corresponding use
发明人：COPPI LAURA; GASANZ GUILLEN YOLANDA; CAMPON PARDO JULIO
权利人:ESTEVE QUIMICA SA
摘要:An intermediate for the synthesis of amlodipine, a process for the preparation thereof and the corresponding use are disclosed. The intermediate is ethyl 3-amino-4-(2-(phthalimido)ethoxy)crotonate and is of formula III:The process for the preparation thereof comprises reacting the acetoacetate of formula:with ammonium acetate; and the use thereof is for the preparation of the compound of formula:the process being conducted by reacting ethyl 3-amino-4-[2-(phthalimido)ethoxy]crotonate with a benzylidene derivative.

专利号:US-8455655-B2
优先权日:2010-05-07
标题:Preparation of dihydropyridines
发明人：VISHNU NEWADKAR RAVINDRANATH; PURUSHOTTAM JOSHI ANIL; KUMAR SINGH SANTOSH
权利人:VISHNU NEWADKAR RAVINDRANATH; PURUSHOTTAM JOSHI ANIL; KUMAR SINGH SANTOSH; LESVI LABORATORIOS SL
摘要:The invention relates to a method and compounds for the preparation of clevidipine butyrate, a very short acting hypertensive calcium antagonist, as well as the synthesis of these compounds useful for the preparation of clevidipine (also known as clevidipine butyrate). Moreover the invention also discloses polymorphic forms of clevidipine butyrate, useful for the preparation of pharmaceutical compositions, and processes to prepare them.

专利号:US-7671208-B2
优先权日:2007-03-30
标题 :Acetone solvate of phthaloyl amlodipine
发明人：BERENGUER MAIMO RAMON; MEDRANO RUPEREZ JORGE; MERODIO CABANILLAS JUAN FRANCISCO
权利人:ESTEVE QUIMICA SA
摘要:An acetone solvate of phthaloyl amlodipine, as well as a process for its preparation including dissolving phthaloyl amlodipine in acetone and cooling the mixture. The present invention also comprises a method for the synthesis of amlodipine, its salts or solvates, which comprises the use of an acetone solvate of phthaloyl amlodipine.

专利号:US-7060838-B2
优先权日:2002-07-01
标 题 :Industrial process for the synthesis of isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nisoldipine)
发明人：FERRARI MASSIMO; GHEZZI MARCELLO; ALBERELLI MANUEL; AMBROSINI ALBERTO
权利人:ERREGIERRE SPA
摘要:Synthetic process of isobutyl methyl 1,4,-dihydro-2,6-dimethyl-4-(2-nitrophenyl)3,5-pyridine dicarboxylate (Nisoldipine) comprising on the reaction of isobutyl 2-(2-nitrobenzylidene)acetoacetate with methyl 3-aminocrotonate in an apolar solvent.

专利号:WO-9925689-A1
优先权日:1997-11-14
标题 :Process for the preparation of acetal derivatives of 1,4-dihydropyridines
发明人：KARUP GUNNAR LEO; PREIKSCHAT HERBERT FRITZ; PEDERSEN SOEREN BOLS
权利人:GEA FARMACEUTISK FABRIK AS; KARUP GUNNAR LEO; PREIKSCHAT HERBERT FRITZ; PEDERSEN SOEREN BOLS
摘要:A process for the preparation of 1,4-dihydropyridine acetal derivatives of formula (II) wherein R1 each, independently, represents H, Cl or CF¿3; R 2 represents H, C¿1 -C5 alkyl, C3-C6 cycloalkyl or aralkyl; R 3 and R4¿ which may be the same or different, represent C¿1 -C5 alkyl, C3-C6 cycloalkyl, aralkyl or together represent -(CH2)m-, wherein m is 2 or 3, and n is 1 or 2, wherein the 1,4-dihydropyridine ring structure is formed by a Hantzsch synthesis carried out in one or more steps using a compound containing a group of formula (a); wherein R 3 and R4¿ have the same meanings as defined above, as one of the reactants in the Hantzsch condensation, is described. The Hantzsch synthesis, or at least one step thereof, is carried out in a solvent, which is capable of forming an azeotrope with water, under azeotropic removal of water of reaction. The compounds of formula (II) are useful as intermediates for the preparation of pharmaceutically active 1,4-dihydropyridines and other intermediates of use for such purpose.