CAS: 1404-19-9; Oligomycin

专利信息

专利号:US-11612610-B2
优先权日:2018-12-14
标题:Mito-magnolol compounds and methods of synthesis and use thereof
发明人：KALYANARAMAN BALARAMAN; ZIELONKA JACEK MICHAL; CHENG GANG; HARDY MICAEL JOËL; OUARI OLIVIER
权利人:MEDICAL COLLEGE WISCONSIN INC; AIX MARSEILLE UNIV; MEDICAL COLLEGE OF WISCONSIN INC
摘要:The present invention provides mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-magnolol compounds in the treatment of cancer, especially anti-cancer therapy or kinase resistant cancers.

专利号:EP-0320272-B1
优先权日:1987-12-09
标 题 :DNA encoding ACV synthetase
发明人：BURNHAM MARTIN KARL RUSSELL; EARL ALISON JANE; BULL JOHN HENRY UNIVERSITY OF; SMITH DAVID JOHN UNIVERSITY OF; TURNER GEOFFREY UNIVERSITY OF
权利人:BEECHAM GROUP PLC
摘要:DNA encoding the gene for the synthetase enzyme capable of generating delta (L- alpha -aminoadipyl)-L- cysteinyl-D-valine (ACV) from its constituent amino acids was obtained from several penicillin and cephalosporin producing organisms, e.g. Penicillium chrysogenum and a Flavobacterium species. The DNA was used to prepare recombinant vectors comprising the ACV synthetase gene and hosts transformed with such vectors. The ACV synthetase gene can form part of a gene cluster comprising other genes involved in beta -lactam biosynthesis and the production of penicillin by expression of the entire biosynthetic gene cluster for the synthesis of penicillin from primary amino acids is described. Suitable hosts in which expression can take place include heterologous hosts which are naturally non-producers of penicillin.

专利号:US-2005085555-A1
优先权日:1997-08-21
标 题:Composition, synthesis and therapeutic applications of polyamines
发明人：MURPHY MICHAEL A; MALACHOWSKI MITCHELL R
摘要:This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicty of neutoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.

专利号:US-10927101-B2
优先权日:2016-05-31
标 题 :Neopetrosides A and B, and synthesis method thereof
发明人：HAN JIN; JEONG SEUNG HUN; SONG IN-SUNG; KIM HYOUNG KYU; KIM NARI; SHUBINA LARISA K; MAKARIEVA TATYANA N; STONIK VALENTIN A; YASHUNSKY DMITRY V; NIFANTIEV NIKOLAY E
权利人:UNIV INJE IND ACAD COOP FOUND
摘要:The present invention relates to novel pyridine nucleoside compounds, Neopetroside A (NPS A) and Neopetroside B (NPS B) obtained by fractionating an extract of Neopetrosia sp. which is a marine sponge, with ethanol, into n-butanol (n-BuOH). When the NPS A was treated with myocardial cells, it activates oxidative phosphorylation, basal and mitochondrial respiration induced by ATP and ATP synthesis, and stimulates the glycolysis activity and when the NPS A was treated with an ischemic reperfusion injury model, the left ventricular pressure injured by ischemic reperfusion was recovered and the size of myocardial injury site was significantly reduced and as a result, can be provided as the pharmaceutical composition for preventing or treating ischemic heart disease or the health functional food for preventing or improving the same.

专利号:WO-2009026858-A1
优先权日:2007-08-28
标题 :Derivatives of acridinone as anti-parasitic, anti-fungal and anti-viral agents
发明人：PELLON CONDOM ROLANDO F; DOCAMPO PALACIOS MAITE L; PARDO ANDREU GILBERTO L; FERNANDEZ-CALIENES VALDES AYME; MENDIOLA MARTINEZ BARBARA JUDITH; ROJAS RIVERO LAZARA; D ACCORSO HAICCK NORMA BEATRIZ; FASCIO SILVA MIRTA LILIANA; DAMONTE LOTITO ELSA BEATRIZ; GARCIA CATTEBEKE CYBELE CARINA; SEPULVEDA SUCHECKI CLAUDIA SOLEDAD; MAZZUCCO GAVIEIRO MARIA BELEN; TALARICO SALINAS LAURA BEATRIZ; MAES LOUIS
权利人:CT DE QUIMICA FARMACEUTICA; PELLON CONDOM ROLANDO F; DOCAMPO PALACIOS MAITE L; PARDO ANDREU GILBERTO L; FERNANDEZ-CALIENES VALDES AYME; MENDIOLA MARTINEZ BARBARA JUDITH; ROJAS RIVERO LAZARA; D ACCORSO HAICCK NORMA BEATRIZ; FASCIO SILVA MIRTA LILIANA; DAMONTE LOTITO ELSA BEATRIZ; GARCIA CATTEBEKE CYBELE CARINA; SEPULVEDA SUCHECKI CLAUDIA SOLEDAD; MAZZUCCO GAVIEIRO MARIA BELEN; TALARICO SALINAS LAURA BEATRIZ; MAES LOUIS
摘要:The invention relates to the synthesis and evaluation of novel organic products as anti-parasitic, anti-fungal and anti-viral agents. More specifically, the invention relates to novel derivatives of 10-alyl- (I), 10-(3methyl-2-butenyl)- (II) and 10-(1,2propanodienyl)-9(10H)-acridinone (III) and a novel family of acridinones, 10-{[3-(6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-il)-4,5-dihydro-5-isoxazolyl] methyl}-9(10H) acridinone (IV) having the following formulas: wherein positions 1, 2, 3, 4, 5, 6, 7 and 8 of the acridinone ring are hydrogen atoms or halogens, groups consisting of hydroxyl, amino, nitro, alkyl with between 1 and 5 carbon atoms, trichloromethyl, trifluoromethyl, alkoxyl with between 1 and 6 carbon atoms (aryloxy substituted), aryl and alkylamino with between 1 and 6 carbon atoms (mono- and di-substituted), aryl and alkylamide with between 1 and 4 atoms of carbon, cyano, carboxyl, formyl, alkyl and arylsulfonic, mercapto substituted with alkylic chains having up to 5 carbon atoms, and sulfoxide aryl. Said derivatives have an activity against Plasmodium falciparum, Trypanosoma brucei and Trypanosoma cruzi protozoans, as well as Microsporum canis and strains of the Junin virus and Dengue.

专利号:US-2004072739-A1
优先权日:1999-11-10
标 题:Compositions and methods for regulating endogenous inhibitor of ATP synthase, including treatment for diabetes
发明人：ANDERSON CHRISTEN M; CLEVENGER WILLIAM
摘要:The present invention provides compositions and methods for altering mitochondrial ATP production, including fusion proteins comprising IF1 polypeptide-derived sequences and also including binding and functional assays exploiting IF1 interactions with ATP synthase. Also disclosed are methods for screening assays for a compound capable of reducing mitochondrial ATP hydrolysis and/or increasing mitochondrial ATP synthesis, including pharmaceutical compositions identified by such methods. The invention also provides methods for treating diabetes, and in particular, type 2 DM, using an agent identified according to the disclosed methods.