专利号:WO-2021038581-A1 优先权日:2019-08-30 标题 :A one step synthesis of 2-substituted benzo[b]thiophenes 发明人:SEKAR GOVINDASAMY; POONGUZHALI ELAMVAZHUTHI 权利人:INDIAN INST TECH MADRAS 摘要:The invention pertains to a one step synthesis of 2-substituted benzo[ b ]thiophene of general formula wherein the synthesis of 2-substituted benzo[ b ]thiophenes is by reacting the starting materials substituted or unsubstituted 2-halogenobenzaldehyde and substituted or unsubstituted acetyl/phenacyl bromide with a catalyst, a sulphur source and phase transfer catalyst in an aqueous medium with atmospheric air and at temperature in the range of 25°C-30°C.
专利号:US-8871975-B2 优先权日:2011-01-05 标题 :Process for the synthesis of agomelatine 发明人:ZARD SAMIR; SIRE BÉATRICE; BOUMEDIENE MEHDI 权利人:ZARD SAMIR; SIRE BÉATRICE; BOUMEDIENE MEHDI; SERVIER LAB 摘要:Process for the industrial synthesis of the compound of formula (I)
专利号:US-7619116-B2 优先权日:2003-12-17 标 题:Intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation 发明人:DAMBRIN VALERY; LENOIR JEAN-YVES; SCHNEIDER JEAN-MARIE; GUILLAMOT GERARD; FOLLET MICHEL; BECKER ABRAM 权利人:PRODUCTS CHIMIQUES AUXILIAIRES 摘要:A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.
专利号:US-6384209-B1 优先权日:1996-08-30 标题 :Sulfur transfer reagents for oligonucleotide synthesis 发明人:TANG JIN-YAN; ZHANG ZHAODA 权利人:AVECIA BIOTECHNOLOGY INC 摘要:The invention relates to the chemical synthesis of oligonucleotides and to chemical entities useful in such synthesis. More particularly, the invention relates to sulfurization of the internucleoside linkages of oligonucleotides. The invention provides new sulfur transfer reagents and processes for their use in sulfurizing oligonucleotides. The sulfur transfer reagents according to the invention are inexpensive to make, stable in storage and highly efficient in sulfurization.
专利号:US-2005130221-A1 优先权日:2001-02-01 标 题:Synthesis for the preparation of compounds for screening as potential tubulin binding agents 发明人:FLYNN BERNARD L; HAMEL ERNEST 权利人:US GOV HEALTH & HUMAN SERV 摘要:The present invention relates to methods for the synthesis of chemical compounds for screening as potential tubulin polymerization inhibitors. The invention also provides chemical compounds with tubulin polymerization inhibitor activity.
专利号:US-9409879-B2 优先权日:2011-03-29 标 题 :Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents 发明人:DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA 权利人:DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA; CENTRE NAT RECH SCIENT 摘要:Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and methods of their use as antimalarial or antischistosomal agents.
摘要:Mérour, J.-Y.; Joseph, B., Science of Synthesis Knowledge Updates, (2017) 1, 281. 摘要:Schnürch, M.; Hämmerle, J.; Stanetty, P., Science of Synthesis Knowledge Updates, (2010) 1, 162. 摘要:Aitken, R. A., Science of Synthesis Knowledge Updates, (2018) 3, 320. 摘要:Aitken, R. A., Science of Synthesis Knowledge Updates, (2018) 3, 321. 摘要:Aitken, R. A., Science of Synthesis Knowledge Updates, (2018) 3, 314.