CAS: 1271-86-9; (Dimethylaminomethyl)Ferrocene

上下游产品

[Fe(η5-C5H5)(η5-C5H3(CH2NMe2)-2)-C,N]2Pb ferr°Cene bis-(dimethylamino)methane formaldehydcyclopentadienyllithium ferr°Cenecarboxylic acid ferr°Cenecarboxaldehyde Cr(II)(2,2'-bipyridine)3

专利信息

专利号:US-8497375-B2
优先权日:2010-06-11
标 题 :Method of synthesis of ferroquine by convergent reductive amination
发明人：FEREY VINCENT; MATEOS-CARO JULIA; MONDIERE REGIS; VAYRON PHILIPPE; VIGNE SYLVIE
权利人:SANOFI SA
摘要:The invention relates to a method of synthesis of ferroquine of formula (F) or of its metabolite of formula (Fm): n n n n n n n n n n n n comprising a reaction of reductive amination, said reaction comprising: n (i) a stage of condensation of an aldehyde-amino ferrocene of formula (III), in which R represents a hydrogen atom or a methyl group, with 7-chloroquinolin-4-amine as shown below, n n n n n n n n n n n n n n n n followed by n (ii) a stage of reduction of the product of condensation obtained in the preceding stage and n (iii) then a stage of hydrolysis of the reaction mixture in the presence of an aqueous solution of ammonia or of citric acid.

专利号:CA-2802161-C
优先权日:2010-06-11
标 题:Method of synthesis of ferroquine by convergent reductive amination

专利号:WO-2011154923-A1
优先权日:2010-06-11
标题 :Method of synthesis of ferroquine by convergent reductive amination

专利号:SG-186247-A1
优先权日:2010-06-11
标 题:Method of synthesis of ferroquine by convergent reductive amination

专利号:CN-102939297-B
优先权日:2010-06-11
标 题:Method for the synthesis of ferroquine by convergent reductive amination

专利号:CN-102939297-A
优先权日:2010-06-11
标题 :Method for the synthesis of ferroquine by convergent reductive amination