CAS: 124351-85-5; ((Cycloheptylamino)Methylene)Diphosphonic Acid

上下游产品

Tetraethyl (Cycloheptylamino)Methyl-1,1-Bisphosphonate 124351-81-1

📜Tetraethyl (Cycloheptylamino)Methyl-1,1-Bisphosphonate置于盐酸体系中,化学反应 2.5H,以63.1%的收率获得英卡膦酸
参考文献:新型骨吸收抑制剂的研究.I.氨基亚甲基双膦酸酯衍生物的合成和药理活性.
标题:新型骨吸收抑制剂的研究.I.氨基亚甲基双膦酸酯衍生物的合成和药理活性.
摘要:合成了一系列氨基亚甲基双膦酸酯衍生物,并使用甲状旁腺激素(pth)诱导的大鼠高钙血症模型(pih模型)评估了其抗吸收活性.在这些化合物中,最终选择了(环庚基氨基)亚甲基双(膦酸)(3J)进行进一步研究,在pih模型和固定化大鼠骨萎缩模型(da模型)中证明其效力是帕米膦酸盐的10倍.讨论了该系列双膦酸酯的结构-活性关系.
Doi:10.1248/cpb.41.688

专利信息

专利号:EP-1566177-A1
优先权日:2004-02-23
标 题:The use of bisphosphonates for treating skin by stimulating of collagen synthesis
发明人：KIM JIN; YOOK JONG IN; KIM NAM HEE; RYU JU KYOUNG
权利人:TIGEN BIOTECH CO LTD
摘要:The present invention relates to a novel use of bisphosphonate, and morenparticularly to a composition for increasing collagen synthesis comprisingnbisphosphonate as an active ingredient, as well as the use thereof. The inventivencomposition comprising the bisphosphonate promotes collagen synthesis, and thus, whennit is applied to the skin, it reduces wrinkles of the skin and makes the skin elastic. Fornthis reason, the inventive composition will be useful as cosmetics for the prevention ornimprovement of skin aging or a wound-healing agent. Furthermore, the inventivencomposition can remarkably increase the collagen synthesis of fibroblasts in vitro , andnthus, can be effectively used in the production of products containing collagen.

专利号:US-2006287257-A1
优先权日:2005-06-20
标 题 :Pharmaceutical compositions to treat diseases caused by mycobacterium
发明人：STOCKEL RICHARD F
权利人:STOCKEL RICHARD F
摘要:The invention teaches the synthesis of pharmaceutical composition and methods of synthesis to treat people and animals infected with a pathogenic mycobacterium. In particular the compositions of this invention are suitable for the treatment of tuberculosis, malaria, and other infections diseases caused by mycobacterium.

专利号:US-2007155693-A1
优先权日:2004-01-19
标 题 :Inhibitor of cancer bone metastasis
发明人：YAGITA AKIKUNI
权利人:ORIENT CANCER THERAPY CO LTD
摘要:The subject of the present invention is to provide means to fully achieve the inhibition of cancer bone metastasis, which was accomplished through the repeated selection of agents with aiming at obtaining more beneficial effects on the inhibition of cancer bone metastasis. The invention is achieved by combining an inhibition substance of the activation of osteoclast caused by the degradation of a signaling molecule, TRAF6, in the activation of osteoclast, a suppressive substance of the differentiation from osteoclast precursor cells to mature osteoclasts, and/or a bone resorption inhibitor and/or a Cox2 synthesis inhibitor. This combination was found to have an extremely high utility for the inhibition of cancer bone metastasis. Further, the invention is achieved by the inhibitor of cancer bone metastasis, wherein an IL-12 production inducer as an inhibition substance of the activation of osteoclast caused by the degradation of a signaling molecule, TRAF6, in the activation of osteoclast, a tyrosine kinase inhibitor as a suppressive substance of the differentiation from osteoclast precursor cells to mature osteoclasts, and/or a bisphosphonate as a bone resorption inhibitor and/or a Cox2 synthesis inhibitor for inhibiting the stimulation of RANKL/RANK receptor are combined.

专利号:US-8183409-B2
优先权日:2004-05-06
标题:High yield and rapid synthesis methods for producing metallo-organic salts
发明人：CHRISTGAU STEPHAN; ANDERSEN JENS E T
权利人:CHRISTGAU STEPHAN; ANDERSEN JENS E T; OSTEOLOGIX AS
摘要:A new method for preparing salts of metal cations and organic acids, especially divalent salts of alkaline earth metal ions from group II of the periodic system and carboxylic acids. The method comprising the use of a high temperature (about 90° or more) and, optionally. high pressure, in order to obtain a higher yield, purity and faster reaction speed than obtained with known synthesis methods. In particular, the present invention relates to the production of strontium salts of carboxylic acids. Novel strontium salts are also provided by the present method.

专利号:US-2022118123-A1
优先权日:2019-02-22
标 题 :Combination of ar antagonists and targeted thorium conjugates
发明人：HAMMER STEFANIE; HAGEMANN URS BEAT; HAENDLER BERNARD; LEJEUNE PASCALE; ZITZMANN-KOLBE SABINE; SCHATZ CHRISTOPH; KARLSSON JENNY
权利人:BAYER AG; BAYER AS
摘要:The present invention covers combinations of at least two components, component A and component B, comprising component A being PSMA-TTC, and component B being an antiandrogen selected form AR antagonists such as from cyproterone acetate, bicalutamide, flutamide, nilutamide, enzalutamide, apalutamide, darolutamide or keto-darolutamide, or an AR degrader such as ARV-110, or an ARN-terminal domain binder such as EPI-506, or an antisense oligonucleotide that reduces AR expression such as EZN-4176 or AZD-5312, or an androgen synthesis inhibitor such as abiraterone, particularly abiraterone acetate, seviteronel, galeterone, orteronel or ketoconazole, or a dual AR antagonist and androgen synthesis inhibitor such as ODM-204. Another aspect of the present invention covers the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly for the treatment of a hyper-proliferative disease.

专利号:US-2009137678-A1
优先权日:2005-07-06
标 题:High yield synthesis methods for producing organic salts of strontium
发明人：CHRISTGAU STEPHAN; ANDERSEN JENS E T
权利人:CHRISTGAU STEPHAN; ANDERSEN JENS E T
摘要:New organic salts of strontium and methods of synthesizing such salts with high purity, high yields and with short processing times, at neutral conditions and at low reaction temperature, such as a temperature at or below 50° C.