CAS: 116026-95-0; Tert-Butyl (4-Formylpyridin-3-yl)Carbamate

该化合物是有机合成的多用途中间体,特别是其反应性甲醛和氨基甲酸酯功能组群的价值.乙丁基乙酰碳酸酯(Boc)保护组增强了稳定性,允许在温酸条件下有控制的去保护.四丁基丙烯基胺混合物是进一步衍生的关键前体,有利于在制药和农用化学研究中应用.其定义明确的再活性特征有利于高效的组合反应,如再处理或核分裂性添加,从而有利于构建复杂的循环循环框架.该化合物的高度纯度和一贯性性能支持在多步骤合成中产生可复制的结果.建议在惰性条件下进行妥善处理,以维护其完整性.

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相似化合物

55279-29-3 179024-65-8 180253-66-1

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MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号2591-86-8 1-甲酰哌啶 | CAS号56700-70-0 N-叔丁氧羰酰胺基-3-吡啶 | CAS号7647-01-0 盐酸 | CAS号7732-18-5 水 | CAS号594-19-4 叔丁基锂 | CAS号55279-29-3 3-氨基吡啶-4-醛 | CAS号316155-87-0 1,7-萘啶-2-羧酸

合成工艺路线路线简述

    📜哌啶-1-甲醛置于正丁基锂,盐酸,Sodium Carbonate体系中,用 四氢呋喃,正戊烷 用作溶剂,化学反应 1.75H,以60%的收率获得(4-甲酰基吡啶-3-基)氨基甲酸叔丁酯
    参考文献:Wo2007/38215
    标题:Wo2007/38215

    海关参考信息

    专利信息


    专利号:WO-2008022467-A1
    优先权日:2006-08-25
    标 题 :2-substituted azain doles and 2 substituted thienopyrroles, their precursors and novel processes for the preparation thereof
    发明人：LAUTENS MARK; YUEN JOSEPHINE; FANG YUANQING
    权利人:LAUTENS MARK; YUEN JOSEPHINE; FANG YUANQING
    摘要:The present invention relates generally to processes for the chemical synthesis of azaindole and thienopyrrole compounds, in particular azaindole and thienopyrrole compounds that are substituted at the 2-position of the azaindole or thienopyrrole ring, and optionally at additional locations of the azaindole or thienopyrrole ring such as the 1- and/or 3-position, compounds prepared by such processes, and synthetic precursors of such processes. More particularly, the present invention relates to the preparation of 2- substituted azaindoles from an ortho-gem-dihalovinylaminopyridine or from an ortho- gem-dihalovinylaminopyridine N-oxide compound and an organoboron reagent using a palladium metal pre-catalyst, base and a ligand. The present invention also relates to the preparation of 2-substituted thienopyrroles from an ortho-gem-dihalovinylthiophene compound and an organoboron reagent using a palladium metal pre-catalyst, base and a ligand. The present invention also relates to processes for the production of ortho-gem- dihalovinylaminopyridines which are useful as starting materials in the production of 2- substituted azaindoles, and novel compounds prepared by the processes. The present invention also relates to processes for the production of ortho-gem-dihalovinylthiophenes which are useful as starting materials in the production of 2-substituted thienopyrroles, and novel compounds prepared by the processes. Formulae (V) and (VII).

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    主要参考文献

    参考标题:Inhibitors Of Cyclic Amp Phosphodiesterase. 3. Synthesis And Biological Evaluation Of Pyrido And Imidazolyl Analogs Of 1,2,3,5-Tetrahydro-2-Oxoimidazo[2,1-B]Quinazoline
    作者:Michael C. Venuti,Robert A. Stephenson,Robert Alvarez,John J. Bruno,Arthur M. Strosberg |发布日期:1988.11
    摘要:Hybridization Of Structural Elements Of 1,2,3,5-Tetrahydro-2-Oxoimidazo[2,1-B]Quinazoline Ring System Common To The Cyclic Amp (Camp) Phosphodiesterase (Pde) Inhibitors Lixazinone (Rs-82856, 1) And Anagrelide (3) With Complementary Features Of Other Pde Inhibitor Cardiotonic Agents Prompted The Design And Synthesis Of The Title Compounds 7A-D, 11, 12, And 13A,B. The Necessary Features Of These Compounds

    合成参考文献

    合成方法参考DOI号:10.1021/jm00119a014
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