CAS: 113942-30-6; 3-Methyl-4-Oxo-3,4-Dihydroimidazo[5,1-D][1,2,3,5]Tetrazine-8-Carboxylic Acid

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85622-93-1 113942-30-6 114601-31-9

上下游产品

CAS号85622-93-1 替莫唑胺

📜替莫唑胺置于硫酸,Sodium Nitrite体系中,用 水 用作溶剂,化学反应 16.0H,以68%的收率获得3,4-二氢-3-甲基-4-氧代咪唑并[5,1-D]-1,2,3,5-四嗪-8-甲酰胺酸
参考文献:A Novel Series Of Phenolic Temozolomide (Tmz) Esters With 4 To 5-Fold Increased Potency,Compared To Tmz,Against Glioma Cells Irrespective Of Mgmt Expression
标题:A Novel Series Of Phenolic Temozolomide (Tmz) Esters With 4 To 5-Fold Increased Potency,Compared To Tmz,Against Glioma Cells Irrespective Of Mgmt Expression
摘要:诊断为多形性胶质母细胞瘤(gbm)的患者的标准治疗是替莫唑胺(tmz).
Doi:10.1039/d0Ra02686G

专利信息

专利号:US-7173021-B2
优先权日:2004-09-02
标题:Synthesis of temozolomide esters as potent anticancer pro-drugs for topical and transdermal applications in treatments of cancers
发明人：WANG YONGFENG; CONWAY BARBARA R; SUPPASANSATORN PANASSAYA
权利人:TIANJIN NORTH PHARM SCI TECH C
摘要:This invention relates to the use of temozolomide esters (4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylate esters) Formula 1 as potent anticancer pro-drugs for treatment of cancers by topical and transdermal applications, and to a novel process for synthesis of temozolomide esters by a direct esterification of temozolomide acid (3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic acid) with a halogeno-aliphatic compound in presence of a base, or with an alcohol in presence of a dehydrate agent

专利号:US-2006047117-A1
优先权日:2004-09-02
标 题 :Synthesis of temozolomide esters as potent anticancer pro-drugs for topical and transdermal applications in treatments of cancers

专利号:CN-115887450-A
优先权日:2022-12-09
标 题:Synthesis of squalene-based temozolomide and preparation and application of self-assembled nanoparticles

专利号:CN-115887450-B
优先权日:2022-12-09
标题:Synthesis of squalene-temozolomide and preparation and application of its self-assembled nanoparticles