CAS: 1071-28-9; (3-Aminopropoxy)Phosphonic Acid

相似化合物

1071-23-4 25457-71-0 1388844-53-8

上下游产品

propan-1-ol-3-amine cyclophosphamide Dechloroethylcyclophosphamide 2,N3-didechloroethylifosfamideN2,N3-didechloroethylifosfamidephosphoric acid mono-(3-benzoylamino-propylester); barium salt 3-N-Phenylthi°Carbamylamino-propyl-phosphorsaeuremonoester

📜3-氨基-1-丙醇置于ppa体系中,化学反应生成磷酸二氢氨基丙酯
参考文献:进行酯的形成和转化.八.酸化氨基醇基磷酸酯
标题:进行酯的形成和转化.八.酸化氨基醇基磷酸酯
摘要:一些氨基烷基磷酸已经通过相应的氨基醇的磷酸化来制备.这些酸已被乙酰化,苯甲酰化和甲苯磺酸化.
Doi:10.1002/hlca.19560390535

专利信息

专利号:US-7777023-B2
优先权日:1998-10-23
标题 :Method for the chemical synthesis of oligonucleotides
发明人：VARGEESE CHANDRA; SHAFFER CHRISTOPHER; WANG WEIMIN
权利人:SIRNA THERAPEUTICS INC
摘要:The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof.

专利号:US-7205399-B1
优先权日:2001-07-06
标 题 :Methods and reagents for oligonucleotide synthesis
发明人：VARGEESE CHANDRA; WANG WEIMIN
权利人:SIRNA THERAPEUTICS INC
摘要:The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof.

专利号:US-2004102389-A1
优先权日:1995-10-26
标题 :Nucleic acid-mediated treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)
发明人：PAVCO PAMELA; MCSWIGGEN JAMES; STINCHCOMB DAN; ESCOBEDO JAIME; KIM JULIAN; LINDNER DANIEL
权利人:RIBOZYME PHARM INC
摘要:The present invention relates to nucleic acid molecules such as ribozymes, DNAzymes, short interfering RNA (siRNA), short interfering nuleic acid (siNA), and antisense which modulate the synthesis, expression and/or stability of an mRNA encoding one or more receptors of vascular endothelial growth factor, such as flt-1 (VEGFR1) and/or KDR (VEGFR2). Nucleic acid molecules and methods for the inhibition of angiogenesis and treatment of cancer and other conditions associated with VEGF-R are provided, optionally in conjunction with other therapeutic agents such as interferons.

专利号:US-2006036090-A1
优先权日:1998-10-23
标题:Method for the chemical synthesis of oligonucleotides

专利号:WO-2018145009-A1
优先权日:2017-02-06
标 题 :Dna-zyme based methods & compositions for treating huntington's disease
发明人：POURMOTABBED TAYEBEH; REINER ANTON
权利人:UNIV TENNESSEE RES FOUND
摘要:Provided herein are methods and compositions for treating Huntington's disease. For example, provided are compositions that include DNA oligonucleotides that have targeting specificity for RNA encoding mutant huntingtin protein. When introduced into a cell, the DNA oligonucleotides reduce expression of the mutant huntingtin protein in a cell. For example, the DNA oligonucleotide, functioning as an enzymatic DNA molecule (or DNAzyme), cleaves the RNA encoding the mutant mRNA protein, thereby rendering the mRNA incapable of expression. That is, the cleavage event renders the RNA non¬ functional and reduces or abrogates protein expression from that RNA. Hence, synthesis of the mutant huntingtin protein is selectively reduced or inhibited, in accordance with the methods and compositions described herein. By silencing or reducing the expression of the mutant huntingtin protein, the methods and compositions describe herein can be used to treat Huntington's disease, including adult and juvenile onset Huntington's disease.

专利号:US-2007276139-A1
优先权日:2004-02-10
标题:Substituted Pixyl Protecting Groups for Oligonucleotide Synthesis
发明人：SONG QUANLAI; KHAMMUNGKHUNE SAK; ROSS BRUCE S; GRIFFEY RICHARD H
权利人:SONG QUANLAI; KHAMMUNGKHUNE SAK; ROSS BRUCE S; GRIFFEY RICHARD H
摘要:The present invention describes an improved hydroxyl protecting group of formula (1), wherein R 2 and R 7 are specified substituents and Q is O, S, NR 10 or N(Câ•?O)R 10 .