CAS: 94-63-3; 2-((Hydroxyimino)Methyl)-1-Methylpyridin-1-Ium Iodide

• 英文名称2-((Hydroxyimino)Methyl)-1-Methylpyridin-1-Ium Iodide
• 中文名称碘解磷啶
• IUPAC名称(E)-2-((hydroxyimino)methyl)-1-methylpyridin-1-ium iodide
• 其它别名Pralidoxime Iodide; 2-Pam Iodide; Protopam Iodide; Pralidoxime Methiodide; Pam (Pharmaceutical); Pyridine-2-Aldoxime Methiodide; Pralidoximi Iodidum; Pyridin-2-Aldoxin; 2-Pyridine Aldoxymethiodide; Pyridine Aldoxime Methiodide; 2-Formyl-1-Methylpyridinium I
• CAS编号94-63-3
• MFCD编号:MFCD00011982
• EINECS号:202-349-6
• FDA UNII编号:7H254VC0NT
• 分子式:C7H9IN2O
• 分子量:264.07
• 产品CID: 1997916
• 同类组份化合物CAS154-97-2 (mesylate); 94-63-3 (iodide); 51-15-0 (Cl)
• 产品分类原料药 → 专科用药 → 解毒药

• 相似结构搜索
• InChIKey: QNBVYCDYFJUNLO-UHDJGPCESA-N
• InChI=1S/C7H8N2O.HI/c1-9-5-3-2-4-7(9)6-8-10;/h2-6H,1H3;1H…
• 计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数1.0

物理性质

• 熔点220  °C (分解)(文献)
• 沸点220 °C (分解)
• 密度1.7439 g/ml
• PSA:36.47
• LogP:-2.6768
• 溶解性DMSO: 250 mg/mL (946.75 Mm)
• 敏感性光敏感
• 外观形态淡黄色至黄色固体
• 储存条件2-8°C
• 产品应用用于烷基磷酸酯类家药中毒的解毒剂.该品是胆碱酯酶再激活剂.
• 性质描述淡黄色针状结晶性粉末.熔点225-226°C.25°C水中溶解度为48mg/ml.碱性溶液中易破坏.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别急性毒性 类别4(经口)
• 警示词Warning(警告)
• 危险描述H302 |吞咽有害.
• 防范说明P264-P270-P301+P312-P501
• UN编号NONH for all modes of transport
• 危险品标志Xn
• 安全声明36-24
• 危险类别码22
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 873-69-8 = 94-63-3
  反应条件:1.1 Solvents: Acetone; Rt; 4 Min
  标题:Microwave-Assisted Quaternization Of Various Pyridine Derivatives And Their Antibacterial Activity
  作者:Busic,Valentina; Pavlovic,Hrvoje; Roca,Suncica; Vikic-Topic,Drazen; Gaso-Sokac,Dajana
  参考文献:Croatica Chemica Acta 日期:2017 卷标:90(3) 页码:425-433]
  
  873-69-8 = 94-63-3
  反应条件:1.1 Solvents: Acetonitrile; 6.5 H,Reflux
  标题:Monoquaternary Pyridinium Salts With Modified Side Chain-Synthesis And Evaluation On Model Of Tabun- And Paraoxon-Inhibited Acetylcholinesterase
  作者:Musilek,Kamil; Kucera,Jiri; Jun,Daniel; Dohnal,Vlastimil; Opletalova,Veronika; Et Al
  参考文献:Bioorganic & Medicinal Chemistry 日期:2008 卷标:16(17) 页码:8218-8223]
  
  873-69-8 = 94-63-3
  反应条件:1.1 Solvents: Acetonitrile; 7 H,80 - 85 °C
  标题:A Simple Process For The Preparation Of Pralidoxime Chloride
  作者:Unnisa,Lateef; Sumakanth,M.; Rao,B. Leelamaheswara; Divi,Murali Krishnaprasad; Rao,Mysore Aswathanarayana
  参考文献:Indian Journal Of Chemistry 日期:2014 卷标:(4) 页码:431-434]
  
  = 94-63-3 [标题:Reaction Conditions
  标题:Synthesis Of Tritium Labeled Oximes: 2-Pyridine Aldoxime Methiodide (2-Pam) And 1-(2-Hydroxyiminomethylpyridinium)-1-(4-Carboxyamidopyridinium) Dimethyl Ether Dichloride (Hi-6),With High Specific Activity
  作者:Balan,Ayala; Barness,Itzhak; Amitai,Gabriel
  参考文献:Journal Of Labelled Compounds And Radiopharmaceuticals 日期:1993 卷标:33(1) 页码:19-32]
  
  = 94-63-3 [标题:Reaction Conditions
  标题:Acetylcholinesterase Reactivators. I. Oxime Of Quinoliniumphenacyl Chloride
  作者:Malatesta,P.; Quaglia,G.; La Floresta,E.
  参考文献:Farmaco 日期:1968 卷标:23(8) 页码:757-64]
  
  873-69-8 = 94-63-3
  反应条件:1.1 Solvents: Acetone; 2 H,Rt; 2 - 3 H,Rt
  标题:A Process For The Preparation Of Formylmethylpyridinium Chloride Oxime
  参考文献:India]
  
  873-69-8 = 94-63-3
  反应条件:1.1 Solvents: Acetone; 4 - 4.5 H,60 °C
  标题:New Methods In Synthesis Of Acetylcholinesterase Reactivators And Evaluation Of Their Potency To Reactivate Cyclosarin-Inhibited Ache
  作者:Musilek,K.; Lipka,L.; Racakova,V.; Kuca,K.; Jun,D.; Et Al
  参考文献:Chemical Papers 日期:2006 卷标:60(1) 页码:48-51]
  
  3784-97-2 = 94-63-3
  反应条件:1.1 Reagents: Hydroxylamine Catalysts: Pyridine Solvents: Ethanol; 40 Min,Reflux
  标题:Design,Synthesis,And Evaluation Of Guanylhydrazones As Potential Inhibitors Or Reactivators Of Acetylcholinesterase
  作者:Petronilho,Elaine Da Conceicao; Renno,Magdalena Do Nascimento; Castro,Newton Goncalves; Da Silva,Fernanda Motta R.; Da Cunha Pinto,Angelo; Et Al
  参考文献:Journal Of Enzyme Inhibition And Medicinal Chemistry 日期:2016 卷标:31(6) 页码:1069-1078]
  
  = 94-63-3 [标题:Reaction Conditions
  标题:Synthesis Of Pyridin-2-Aldoxime Methiodide
  作者:Binenfeld,Zlatko; Vorkapic,Jasna
  参考文献:Farmaceutski Glasnik 日期:1969 卷标:25(6-7) 页码:257-8]
  
  = 94-63-3 [标题:Reaction Conditions
  标题:Mechanism And Specificity Of Legal'S Test
  作者:Roth,Hermann J.; Surborg,K. H.
  参考文献:Archiv Der Pharmazie Und Berichte Der Deutschen Pharmazeutischen Gesellschaft 日期:1968 卷标:301(9) 页码:686-95]
  
  = 94-63-3 [标题:Reaction Conditions
  标题:Synthesis Of 2-Formyl-1-Methylpyridinium Iodide Oxime
  作者:Hach,Vladimir; Kvita,Vratislav
  参考文献:Cesko-Slovenska Farmacie 日期:1964 卷标:13 页码:399-400

海关参考信息

• 2933310010-吡啶
  2939800000-其他生物碱
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管