CAS: 89364-41-0; 1,4-Dioxane-2-Carboxylic Acid

该化合物是一种杂交碳盒状酸,其特点是二恶英环状结构,为合成应用提供了独特的反应性和稳定性,其双功能性-结合一个醚联系和一个碳箱状组-使它成为有机合成的多功能中间体,特别是用于建造复杂的异氧循环或作为制药和农用化学开发的手工业建筑块.该化合物的硬二恶英脚架可增强反应中的立体化学控制,而箱式酸混合物允许进一步的衍生.由于其平衡的极化和相容性限制,它通常用于药用化学,用于结构活动关系.

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相似化合物

1932281-42-9 406913-88-0 406913-93-7

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上下游产品

2-羟基甲基-1,4-二氧杂烷 (1,4-Dioxan-2-yl)Methanol 29908-11-0

合成工艺路线路线简述

  • 29908-11-0 = 89364-41-0
    反应条件:1.1 Reagents: Sodium Nitrite,Nitric Acid
    标题:Oxidation Of 1,3- And 1,4-Dioxanes By Nitric Acid
    作者:Gevorkyan,A. A.; Sargsyan,M. S.; Manukyan,A. T.; Khizantsyan,N. M.; Mkrtumyan,S. A.
    参考文献:Armyanskii Khimicheskii Zhurnal 日期:1991 卷标:44(7-8) 页码:443-8]

    14717-00-1 = 89364-41-0
    反应条件:1.1 Solvents: Water
    标题:Preparation And Derivatives Of Cyano-1,4-Dioxane
    作者:Nelson,B. A.; Minsek,R. C.; Simon,J. I.; Underwood,D. L.
    参考文献:Journal Of The American Chemical Society 日期:1955 卷标:77 页码:1695-6
📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于sodium Hydroxide体系中,化学反应生成 1,4-二氧杂烷-2-羧酸
参考文献:Preparation And Derivatives Of Cyano-1,4-Dioxane
标题:Preparation And Derivatives Of Cyano-1,4-Dioxane
摘要:
DOI:10.1021/ja01611A096

海关参考信息

专利信息


专利号:US-4397843-A
优先权日:1980-10-23
标 题:Mannose-6-phosphate-low density protein reagent effective against hypercholesterolemia
发明人:NEVILLE JR DAVID M; YOULE RICHARD J; MURRAY GARY J
权利人:US HEALTH
摘要:A new reagent effective in inhibiting cholesterol synthesis 75% in human fibroblasts derived from patients suffering from the disease familial hypercholestrolemia is Man6P-low density lipoprotein and is effective in tissue culture test systems at 100 μg/ml after a ten-hour exposure. The broad purpose of this invention is to modify the receptor specificity of a protein so that it will enter cells which were previously impermeable and exert new effects or reverse a pathological condition. That is, the compound of this invention is a useful reagent in the selective cytotoxic treatment of hypercholesterolemia.

专利号:TW-201204753-A
优先权日:2010-04-30
标题 :Polymers bearing pendant pentafluorophenyl ester groups, and methods of synthesis and functionalization thereof

专利号:US-4868167-A
优先权日:1988-05-20
标题:Novel peptidyl amino steroids
发明人:MOKOTOFF MICHAEL; LIAO QING-JIANG; WONG LAN; ZHAO MING
权利人:UNIV PITTSBURGH
摘要:The invention relates to novel peptidyl derivatives of Amefalone, Pro-Amefalone, Pro-Pro-Amefalone and D-Ala-Pro-Amefalone, their halide, preferably hydrochloride, salts, to a process for their synthesis and to their use as antiarrhythmic agents.

专利号:CN-113121540-B
优先权日:2020-01-15
标题:A kind of synthesis method of sitagliptin free base

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合成参考文献


参考文献:10.1186/s12893-024-02700-z
摘要:Baumann P, Sánchez LH, Garcia NG, Sologiuc L, Hornemann A. Assessment of a novel unidirectional mid-term absorbable barbed suture versus a competitor barbed suture for vaginal cuff closure after gynaecology surgery, study protocol of a randomized controlled trial - BARHYSTER. BMC Surg. 2025 Jan 14;25(1):23.
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