CAS: 83-40-9; 2-Hydroxy-3-Methylbenzoic Acid

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CAS号124-38-9 二氧化碳 | CAS号95-48-7 邻甲酚 | CAS号56-23-5 四氯化碳 | CAS号5061-21-2 α-溴-γ-丁内酯 | CAS号23287-26-5 3-甲基水杨酸甲酯 | CAS号1427465-41-5 1-phenyl-7-meth... | CAS号99-04-7 间甲基苯甲酸 | CAS号298-14-6 碳酸氢钾 | CAS号55211-85-3 4-羟基-3-甲基苯甲酸乙酯 | CAS号36194-82-8 5-溴-2-羟基-3-甲基苯甲酸 | CAS号4386-39-4 2-乙酰基-3-甲基苯甲酸 | CAS号15198-07-9 2-hydroxy-3-met... | CAS号192752-93-5 2-chloro-8-meth... | CAS号1951-38-8 2-甲氧基间苯二甲酸 | CAS号2581-36-4 Benzoic acid,3,... | CAS号27893-05-6 (2-carbon°Chlor... | CAS号824-42-0 3-甲基水杨醛 | CAS号30991-42-5 2-羟基-3-甲基亚苯基肼 | CAS号23287-26-5 3-甲基水杨酸甲酯

4-羟基-3-甲基苯甲酸乙酯置于palladium On Activated Charcoal 氢气体系中,用 乙醇,溶剂黄146 作为反应溶剂,化学反应生成 3-甲基水杨酸
参考文献:Wessely,F. Et Al.,Chemische Berichte,1960,Vol. 93,P. 2840-2851
标题:Wessely,F. Et Al.,Chemische Berichte,1960,Vol. 93,P. 2840-2851

专利信息

专利号:US-6025502-A
优先权日:1999-03-19
标题:Enantopselective synthesis of methyl phenidate
发明人：WINKLER JEFFREY DAVID; AXTEN JEFFREY M; KRIM LORI
权利人:UNIV PENNSYLVANIA
摘要:The invention relates to an enantioselective method of making methylphenidate and derivatives thereof. The method involves use of a rhodium catalyst, and selectively produces the D-enantiomer of the methylphenidate derivative in excess of the L-enantiomer thereof. Furthermore, the method selectively produces the threo-diastereomer in excess of the erythro-diastereomer. The method is thus suitable for synthesis of D-threo-methylphenidate (the biologically active form of this compound) and derivatives thereof.

专利号:WO-2024172286-A1
优先权日:2023-02-14
标题 :Synthesis of photodegradable iron nitrosyl complex and development of pharmaceutical composition for prevention or treatment of vascular diseases, using same
发明人：CHO JAEHEUNG; LEE JUNYEOP; CHOE JISU
权利人:ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECH; ASAN FOUND; UNIV ULSAN FOUND IND COOP
摘要:The present invention relates to a compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof, a compound represented by chemical Formula 2 or a pharmaceutically acceptable salt thereof, a preparation method thereof, and uses of the compound represented by chemical formula 2 or a pharmaceutically acceptable salt thereof. The compound represented by chemical formula 2 or a pharmaceutically acceptable salt thereof exhibits the effect of releasing nitric oxide in vivo upon light stimulation, thereby dilating blood vessels.

专利号:US-11155562-B2
优先权日:2014-06-30
标 题 :Synthesis of halichondrin analogs and uses thereof
发明人：KISHI YOSHITO; UEDA ATSUSHI; YAMAMOTO AKIHIKO; KATO DAISUKE
权利人:HARVARD COLLEGE
摘要:The present invention provides halichondrin analogs, such as compounds of Formula (I). The compounds may bind to microtubule sites, thereby inhibiting microtubule dynamics. Also provided are methods of synthesis, pharmaceutical compositions, kits, methods of treatment, and uses that involve the compounds for treatment of a proliferative disease (e.g., cancer). Compounds of the present invention are particularly useful for the treatment of metastatic breast cancer, non-small cell lung cancer, prostate cancer, and sarcoma. The included methods of synthesis are useful for the preparation of compounds of Formula (I)-(III) along with naturally occurring halicondrins (e.g., halichondrin B & C, norhalichondrin A, B, & C, and homohalichondrin A, B, & C). Also included are methods for interconverting between the halichondrins, norhalichondrins, and homohalichondrins and their unnatural epimers at the C38 ketal stereocenter through the use of an acid-mediated equilibration.

专利号:US-9982005-B2
优先权日:2013-04-04
标 题 :Macrolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

专利号:US-8304409-B2
优先权日:2002-07-03
标 题:Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
发明人：EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI
权利人:EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI; NICOX SA
摘要:The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.

专利号:US-8557979-B2
优先权日:2004-06-10
标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
发明人：CHOI WOO-BAEG; KOWALIK EWA
权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.