CAS: 810668-57-6; 2-Chloro-6,7-Dihydro-5H-Pyrrolo[3,4-B]Pyridine
该化合物是热循环有机化合物,其特点是有引信的火花和环.该化合物具有2位置的氯子子分组成,可影响其再活性和生物活动.二氢化合物的存在表明,该化合物具有两个额外的氢原子,表明该化合物在特定位置处于饱和状态,可影响其稳定性和与其他分子的相互作用.这种化合物通常会表现出有趣的药理特性,使其对药用化学产生兴趣.分子结构允许与生物目标的潜在互动,而氯原子可增强脂性,影响化合物的溶性和易感性.与许多热循环一样,该化合物的氮原子的电子特性也可以在化合物的化学行为和再活动中发挥重要作用.
相似化合物
147740-02-1 1841081-37-5 1257854-60-6物理性质
MSDS等安全信息
合成工艺路线路线简述
- 127437-44-9 = 810668-57-6
反应条件:1.1 Reagents: Cesium Carbonate Solvents: Dimethylformamide; Overnight,Rt2.1 Reagents: Calcium Chloride,Sodium Borohydride Solvents: Tetrahydrofuran; 1 H,Rt; 13 H,Rt2.2 Reagents: Methanol,Potassium Carbonate3.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; 30 Min,0 °C; 0 °C -> Rt; Overnight,Rt4.1 Reagents: Sodium Hydride Solvents: Dimethylformamide; 1 H,Rt4.2 1 H,Rt; Rt -> 70 °C; 1 H,70 °C5.1 Reagents: Phenol,Hydrogen Bromide Solvents: Acetic Acid; 0.5 H,Reflux
标题:A Facile Synthesis Of 2-Chloro-5,7-Dihydropyrrolo[3,4-B]Pyridine-6-Carboxamidine,An Annulated Nicotinoid
作者:Cho,Kwang-Nym; Et Al
参考文献:Bulletin Of The Korean Chemical Society 日期:2004 卷标:25(6) 页码:924-926]
810668-56-5 = 810668-57-6
反应条件:1.1 Reagents: Phenol,Hydrogen Bromide Solvents: Acetic Acid; 0.5 H,Reflux
标题:A Facile Synthesis Of 2-Chloro-5,7-Dihydropyrrolo[3,4-B]Pyridine-6-Carboxamidine,An Annulated Nicotinoid
作者:Cho,Kwang-Nym; Et Al
参考文献:Bulletin Of The Korean Chemical Society 日期:2004 卷标:25(6) 页码:924-926]
220001-94-5 + 70-55-3 = 810668-57-6
反应条件:1.1 Reagents: Sodium Hydride Solvents: Dimethylformamide; 1 H,Rt1.2 1 H,Rt; Rt -> 70 °C; 1 H,70 °C2.1 Reagents: Phenol,Hydrogen Bromide Solvents: Acetic Acid; 0.5 H,Reflux
标题:A Facile Synthesis Of 2-Chloro-5,7-Dihydropyrrolo[3,4-B]Pyridine-6-Carboxamidine,An Annulated Nicotinoid
作者:Cho,Kwang-Nym; Et Al
参考文献:Bulletin Of The Korean Chemical Society 日期:2004 卷标:25(6) 页码:924-926]
220001-93-4 = 810668-57-6
反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; 30 Min,0 °C; 0 °C -> Rt; Overnight,Rt2.1 Reagents: Sodium Hydride Solvents: Dimethylformamide; 1 H,Rt2.2 1 H,Rt; Rt -> 70 °C; 1 H,70 °C3.1 Reagents: Phenol,Hydrogen Bromide Solvents: Acetic Acid; 0.5 H,Reflux
标题:A Facile Synthesis Of 2-Chloro-5,7-Dihydropyrrolo[3,4-B]Pyridine-6-Carboxamidine,An Annulated Nicotinoid
作者:Cho,Kwang-Nym; Et Al
参考文献:Bulletin Of The Korean Chemical Society 日期:2004 卷标:25(6) 页码:924-926]
32383-03-2 = 810668-57-6
反应条件:1.1 Reagents: Calcium Chloride,Sodium Borohydride Solvents: Tetrahydrofuran; 1 H,Rt; 13 H,Rt1.2 Reagents: Methanol,Potassium Carbonate2.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; 30 Min,0 °C; 0 °C -> Rt; Overnight,Rt3.1 Reagents: Sodium Hydride Solvents: Dimethylformamide; 1 H,Rt3.2 1 H,Rt; Rt -> 70 °C; 1 H,70 °C4.1 Reagents: Phenol,Hydrogen Bromide Solvents: Acetic Acid; 0.5 H,Reflux
标题:A Facile Synthesis Of 2-Chloro-5,7-Dihydropyrrolo[3,4-B]Pyridine-6-Carboxamidine,An Annulated Nicotinoid
作者:Cho,Kwang-Nym; Et Al
参考文献:Bulletin Of The Korean Chemical Society 日期:2004 卷标:25(6) 页码:924-926]
612-62-4 = 810668-57-6
反应条件:1.1 Reagents: Ruthenium Trichloride,Periodic Acid (H5Io6) Solvents: Carbon Tetrachloride,Acetonitrile,Water; 4 H,25 - 40 °C2.1 Reagents: Cesium Carbonate Solvents: Dimethylformamide; Overnight,Rt3.1 Reagents: Calcium Chloride,Sodium Borohydride Solvents: Tetrahydrofuran; 1 H,Rt; 13 H,Rt3.2 Reagents: Methanol,Potassium Carbonate4.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; 30 Min,0 °C; 0 °C -> Rt; Overnight,Rt5.1 Reagents: Sodium Hydride Solvents: Dimethylformamide; 1 H,Rt5.2 1 H,Rt; Rt -> 70 °C; 1 H,70 °C6.1 Reagents: Phenol,Hydrogen Bromide Solvents: Acetic Acid; 0.5 H,Reflux
标题:A Facile Synthesis Of 2-Chloro-5,7-Dihydropyrrolo[3,4-B]Pyridine-6-Carboxamidine,An Annulated Nicotinoid
作者:Cho,Kwang-Nym; Et Al
参考文献:Bulletin Of The Korean Chemical Society 日期:2004 卷标:25(6) 页码:924-926
📜(6-Chloropyridine-2,3-Diyl)Dimethanol置于氯化亚砜,苯甲醚,N,N-二异丙基乙胺,三氟乙酸体系中,用 二氯甲烷 作为反应溶剂,化学反应 89.25H,反应生成 2-氯-6,7-二氢-5H-吡咯并[3,4-B]吡啶
参考文献:Wo2024081775A1
标题:Wo2024081775A1
海关参考信息
- 2933310010-吡啶
2921199090-其他无环单胺
2939800000-其他生物碱 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2024081775-A1
优先权日:2022-10-14
标 题:Synthesis of 6-fluoro-2-methylbenzo[d]thiazol-5-yl compounds
发明人：WOERLY ERIC MICHAEL; LINDSAY-SCOTT PETER JAMES
权利人:LILLY CO ELI
摘要:The present invention provides improved reaction schemes and novel reaction intermediates for the synthesis of molecules useful as O-GlcNAcase (OGA) inhibitors.
