专利号:US-2023242482-A9 优先权日:2019-07-26 标 题:Discovery, total synthesis, and bioactivity of doscadenamides 发明人:LUESCH HENDRIK; LIANG XIAO; MATTHEW SUSAN; KWAN JASON C; CHEN QI-YIN; PAUL VALERIE J 权利人:UNIV FLORIDA; SMITHSONIAN INST 摘要:The invention is directed towards compounds (e.g., Formulae (I)-(IX)), their mechanism of action, processes to prepare the compounds, methods of activating quorum sensing signaling activity, and methods of treating diseases and disorders using the compounds described herein (e.g., Formulae (I)-(IX)).
专利号:US-6723321-B2 优先权日:1998-07-31 标题:Autoinducer synthase modulating compounds and uses thereof 发明人:GREENBERG E PETER; CRONAN JR JOHN E; PLAPP BRYCE V; PARSEK MATTHEW R 权利人:UNIV ILLINOIS; UNIV IOWA RES FOUND 摘要:Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifing modulators of the autoinducer synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can be used for therapeutic treatment of bacterial infections particularly in immunocompromised subjects. They are also useful in treating disease states associated with autoinducer synthesis and biofilm development.
专利号:EP-1834645-A1 优先权日:1998-07-31 标 题:Autoinducer synthase modulating compounds and uses therefor 发明人:CRONAN JOHN E JR; PLAPP BRYCE V; GREENBERG E PETER; PARSEK MATTHEW R 权利人:UNIV IOWA RES FOUND 摘要:Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifying modulators of the autoinducers synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can be used for therapeutic treatment of bacterial infections particularly in immunocompromised subjects. They are also useful in treating disease states associated with autoinducer synthesis and biofilm development.
专利号:US-2025034519-A1 优先权日:2022-03-30 标题:Hydrogelated cells 发明人:TAN CHEEMENG; CONTRERAS LLANO LUIS E; HU CHE-MING J 权利人:UNIV CALIFORNIA; ACADEMIA SINICA 摘要:Assembly of a synthetic polymer network inside cells is described that renders the cells incapable of dividing. The resulting cells can retain functions, including for example, cellular metabolism, motility, protein synthesis, and compatibility with genetic circuits. The cells can also acquire new abilities to resist stressors that otherwise kill natural cells.
专利号:US-2022281816-A1 优先权日:2019-07-26 标题 :Discovery, total synthesis, and bioactivity of doscadenamides