CAS: 76924-95-3; 3-Oxo-N-(2-Oxotetrahydrofuran-3-yl)Hexanamide

该化合物是一种化学化合物,以四氢-2-oxo-3-furany 组替代六氯化萘主干柱,该化合物的特点是存在一个氯酮功能组(3-oxo)和一个氨化功能组,这有助于其再活性和有机合成的潜在应用;四氢呋喃环增加了一种循环结构,能够影响化合物的物理特性,例如溶性点和沸点.这种性质的化合物通常会显示生物活动,使它们在制药研究中感兴趣.

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3-ox°Caproic acid L-homoserine lactone 2-(2-propyl-1,3-dioxolan-2-yl)acetic acid N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

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    专利信息


    专利号:US-2023242482-A9
    优先权日:2019-07-26
    标 题:Discovery, total synthesis, and bioactivity of doscadenamides
    发明人:LUESCH HENDRIK; LIANG XIAO; MATTHEW SUSAN; KWAN JASON C; CHEN QI-YIN; PAUL VALERIE J
    权利人:UNIV FLORIDA; SMITHSONIAN INST
    摘要:The invention is directed towards compounds (e.g., Formulae (I)-(IX)), their mechanism of action, processes to prepare the compounds, methods of activating quorum sensing signaling activity, and methods of treating diseases and disorders using the compounds described herein (e.g., Formulae (I)-(IX)).

    专利号:US-6723321-B2
    优先权日:1998-07-31
    标题:Autoinducer synthase modulating compounds and uses thereof
    发明人:GREENBERG E PETER; CRONAN JR JOHN E; PLAPP BRYCE V; PARSEK MATTHEW R
    权利人:UNIV ILLINOIS; UNIV IOWA RES FOUND
    摘要:Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifing modulators of the autoinducer synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can be used for therapeutic treatment of bacterial infections particularly in immunocompromised subjects. They are also useful in treating disease states associated with autoinducer synthesis and biofilm development.

    专利号:EP-1834645-A1
    优先权日:1998-07-31
    标 题:Autoinducer synthase modulating compounds and uses therefor
    发明人:CRONAN JOHN E JR; PLAPP BRYCE V; GREENBERG E PETER; PARSEK MATTHEW R
    权利人:UNIV IOWA RES FOUND
    摘要:Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifying modulators of the autoinducers synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can be used for therapeutic treatment of bacterial infections particularly in immunocompromised subjects. They are also useful in treating disease states associated with autoinducer synthesis and biofilm development.

    专利号:US-2025034519-A1
    优先权日:2022-03-30
    标题:Hydrogelated cells
    发明人:TAN CHEEMENG; CONTRERAS LLANO LUIS E; HU CHE-MING J
    权利人:UNIV CALIFORNIA; ACADEMIA SINICA
    摘要:Assembly of a synthetic polymer network inside cells is described that renders the cells incapable of dividing. The resulting cells can retain functions, including for example, cellular metabolism, motility, protein synthesis, and compatibility with genetic circuits. The cells can also acquire new abilities to resist stressors that otherwise kill natural cells.

    专利号:US-2022281816-A1
    优先权日:2019-07-26
    标题 :Discovery, total synthesis, and bioactivity of doscadenamides

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    合成参考文献


    参考文献:10.1094/mpmi.2004.17.5.521
    摘要:Quiñones B, Pujol CJ, Lindow SE. Regulation of AHL production and its contribution to epiphytic fitness in Pseudomonas syringae. Mol Plant Microbe Interact. 2004 May;17(5):521–31. doi: 10.1094/mpmi.2004.17.5.521.
    参考文献:10.1128/jcm.00330-05
    摘要:Voigt W, Fruth A, Tschäpe H, Reissbrodt R, Williams PH. Enterobacterial Autoinducer of Growth Enhances Shiga Toxin Production by Enterohemorrhagic Escherichia coli. J Clin Microbiol. 2006 Jun;44(6):2247–9. doi: 10.1128/jcm.00330-05.
    参考文献:10.3390/s140509145
    摘要:Yunos NY, Tan WS, Mohamad NI, Tan PW, Adrian TG, Yin WF, Chan KG. Discovery of Pantoea rodasii strain ND03 that produces N-(3-Oxo-hexanoyl)-L-homoserine lactone. Sensors (Basel). 2014 May 23;14(5):9145–52.
    参考文献:10.1021/acssynbio.0c00370
    摘要:Jiang W, He X, Luo Y, Mu Y, Gu F, Liang Q, Qi Q. Two Completely Orthogonal Quorum Sensing Systems with Self-Produced Autoinducers Enable Automatic Delayed Cascade Control. ACS Synth Biol. 2020 Sep 18;9(9):2588–99. doi: 10.1021/acssynbio.0c00370.
    参考文献:10.1128/jb.186.3.631-637.2004
    摘要:Urbanowski ML, Lostroh CP, Greenberg EP. Reversible Acyl-Homoserine Lactone Binding to Purified Vibrio fischeri LuxR Protein. J Bacteriol. 2004 Feb;186(3):631–7. doi: 10.1128/jb.186.3.631-637.2004.
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